| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Avatar | - | - | - | $52,836,032 | 856 | $93,746,295 | Jan 15 | 20th Century Fox International | false |
| 2 | Sherlock Holmes | - | - | - | $16,579,943 | 394 | $26,955,437 | Dec 25 | Warner Bros. | false |
| 3 | Me, Them and Lara | - | - | - | $15,877,547 | 576 | $21,347,896 | Jan 5 | Warner Bros. | false |
| 4 | Hachi: A Dog's Tale | - | - | - | $7,092,106 | 251 | $7,465,403 | Dec 30 | Lucky Red | false |
| 5 | Natale a Beverly Hills | - | - | - | $6,466,620 | 621 | $29,916,370 | Dec 18 | Filmauro | false |
| 6 | The First Beautiful Thing | - | - | - | $6,170,097 | 350 | $9,115,665 | Jan 15 | Medusa Distribuzione | false |
| 7 | Me and Marilyn | - | - | - | $6,152,225 | 563 | $18,842,502 | Dec 18 | Medusa Distribuzione | false |
| 8 | The Princess and the Frog | - | - | - | $5,055,252 | 446 | $13,157,233 | Dec 18 | Walt Disney Pictures | false |
| 9 | Kiss Me Again | - | - | - | $4,325,763 | 584 | $12,373,612 | Jan 29 | Medusa Distribuzione | false |
| 10 | Cloudy with a Chance of Meatballs | - | - | - | $4,261,542 | 308 | $6,448,099 | Dec 23 | Sony Pictures Releasing | false |
| 11 | Up in the Air | - | - | - | $4,142,186 | 339 | $7,439,717 | Jan 22 | United International Pictures | false |
| 12 | Surrogates | - | - | - | $3,189,949 | 197 | $3,118,374 | Jan 8 | Walt Disney Pictures | false |
| 13 | A Christmas Carol | - | - | - | $3,184,890 | 504 | $22,530,311 | Dec 3 | Walt Disney Pictures | false |
| 14 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $2,561,529 | 344 | $8,197,134 | Jan 29 | 20th Century Fox International | false |
| 15 | The Hedgehog | - | - | - | $2,495,521 | 199 | $3,236,371 | Jan 5 | Eagle Pictures | false |
| 16 | Soul Kitchen | - | - | - | $1,821,894 | 100 | $2,371,166 | Jan 8 | BIM Distribuzione | false |
| 17 | Cado dalle nubi | - | - | - | $1,738,013 | 430 | $19,573,511 | Nov 27 | Medusa Distribuzione | false |
| 18 | The Fourth Kind | - | - | - | $1,714,695 | 155 | $2,426,800 | Jan 22 | Warner Bros. | false |
| 19 | Brothers | - | - | - | $1,493,448 | 201 | $3,266,025 | Dec 23 | 01 Distribution | false |
| 20 | Nine | - | - | - | $1,347,134 | 250 | $1,604,773 | Jan 22 | 01 Distribution | false |
| 21 | A Single Man | - | - | - | $1,017,148 | 56 | $1,531,617 | Jan 15 | - | false |
| 22 | Arthur and the Revenge of Maltazard | - | - | - | $875,023 | 60 | $928,560 | Dec 30 | - | false |
| 23 | [Rec]² | - | - | - | $797,690 | 146 | $1,161,285 | Jan 5 | Sony Pictures Releasing | false |
| 24 | Pet Pals: Marco Polo's Code | - | - | - | $784,866 | 172 | $994,776 | Jan 22 | 01 Distribution | false |
| 25 | Welcome | - | - | - | $694,807 | 40 | $1,253,705 | Dec 11 | Teodora Film | false |
| 26 | The Man Who Will Come | - | - | - | $597,941 | 69 | $1,877,452 | Jan 22 | Mikado Film | false |
| 27 | Bangkok Dangerous | - | - | - | $556,695 | 143 | $1,418,034 | Jan 29 | Eagle Pictures | false |
| 28 | Looking for Eric | - | - | - | $527,184 | 80 | $2,330,354 | Dec 4 | BIM Distribuzione | false |
| 29 | Amelia | - | - | - | $520,072 | 177 | $1,604,777 | Dec 23 | 20th Century Fox International | false |
| 30 | A Serious Man | - | - | - | $471,540 | 249 | $3,644,266 | Dec 4 | Medusa Distribuzione | false |
| 31 | The Cézanne Affair/The Man Who Will Come | - | - | - | $270,950 | 253 | $2,239,181 | Dec 4 | 01 Distribution | false |
| 32 | Ten Winters | - | - | - | $189,597 | - | $688,027 | Dec 11 | - | false |
| 33 | Dorian Gray | - | - | - | $148,590 | 238 | $8,249,394 | Nov 27 | Eagle Pictures | false |
| 34 | First Snow 2010 Re-release | - | - | - | $137,833 | 16 | $189,218 | Jan 22 | Eagle Pictures | false |
| 35 | Broken Embraces | - | - | - | $111,537 | 351 | $5,199,445 | Nov 13 | Warner Bros. | false |
| 36 | The Wedding Song | - | - | - | $86,723 | 11 | $148,452 | Dec 18 | - | false |
| 37 | Astro Boy | - | - | - | $54,264 | 216 | $696,229 | Dec 18 | Eagle Pictures | false |
| 38 | Moon | - | - | - | $43,440 | 11 | $155,407 | Dec 4 | Sony Pictures Releasing | false |
| 39 | The Boy in the Striped Pajamas | - | - | - | $39,326 | 103 | $3,802,419 | Dec 19 | Walt Disney Pictures | false |
| 40 | The Ugly Truth | - | - | - | $5,207 | 205 | $3,210,325 | Nov 27 | Sony Pictures Releasing | false |
| 41 | Nobel Son 2010 Re-release | - | - | - | $5,200 | 2 | $5,200 | Jan 15 | Eagle Pictures | false |
| 42 | 2012 | - | - | - | $3,422 | 577 | $21,086,983 | Nov 13 | Sony Pictures Releasing | false |
| 43 | Inglourious Basterds | - | - | - | $3,320 | 465 | $13,380,924 | Oct 2 | United International Pictures | false |
| 44 | Alvin and the Chipmunks | - | - | - | $2,561 | 256 | $5,481,266 | Jan 18 | 20th Century Fox International | false |
| 45 | Frozen River | - | - | - | $1,869 | 20 | $267,882 | Mar 13 | Archibald | false |
| 46 | Fateless | - | - | - | $1,670 | 69 | $305,955 | Jan 27 | Medusa Distribuzione | false |
| 47 | Up | - | - | - | $1,603 | 652 | $22,494,067 | Oct 15 | Walt Disney Pictures | false |
| 48 | Garage | - | - | - | $1,587 | 8 | $98,340 | Jun 5 | - | false |
| 49 | The Reader | - | - | - | $1,577 | 161 | $3,645,596 | Feb 20 | 01 Distribution | false |
| 50 | Everything Is Illuminated | - | - | - | $1,513 | 25 | $1,094,152 | Nov 11 | Warner Bros. | false |
| 51 | Whatever Works | - | - | - | $1,321 | 329 | $7,399,626 | Sep 18 | Medusa Distribuzione | false |
