| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Avatar | - | - | - | $4,855,154 | 124 | $10,818,765 | Dec 17 | 20th Century Fox International | false |
| 2 | Sherlock Holmes | - | - | - | $703,947 | 65 | $1,263,442 | Jan 21 | Warner Bros. | false |
| 3 | Tooth Fairy | - | - | - | $460,468 | 38 | $526,596 | Jan 7 | 20th Century Fox International | false |
| 4 | Paranormal Activity | - | - | - | $410,551 | 38 | $654,695 | Dec 24 | - | false |
| 5 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $319,430 | 54 | $1,424,935 | Jan 28 | 20th Century Fox International | false |
| 6 | The Princess and the Frog | - | - | - | $316,988 | 49 | $904,105 | Dec 3 | Walt Disney Pictures | false |
| 7 | Old Dogs | - | - | - | $245,884 | 30 | $360,864 | Dec 24 | Walt Disney Pictures | false |
| 8 | Surrogates | - | - | - | $166,824 | 31 | $162,762 | Jan 7 | Walt Disney Pictures | false |
| 9 | Astro Boy | - | - | - | $116,538 | 27 | $188,580 | Jan 21 | - | false |
| 10 | Saw VI | - | - | - | $114,759 | 27 | $174,417 | Jan 21 | Walt Disney Pictures | false |
| 11 | 9 | - | - | - | $102,027 | 26 | $102,027 | Dec 31 | - | false |
| 12 | 2012 | - | - | - | $95,297 | 78 | $4,107,761 | Nov 12 | Sony Pictures Releasing | false |
| 13 | Did You Hear About the Morgans? | - | - | - | $92,848 | 27 | $92,848 | Jan 7 | Sony Pictures Releasing | false |
| 14 | Broken Embraces | - | - | - | $87,723 | 14 | $102,541 | Jan 14 | United International Pictures | false |
| 15 | Cirque du Freak: The Vampire's Assistant | - | - | - | $85,873 | 27 | $83,300 | Jan 7 | United International Pictures | false |
| 16 | Zombieland | - | - | - | $79,956 | 30 | $79,956 | Dec 31 | Sony Pictures Releasing | false |
| 17 | The Haunting in Connecticut | - | - | - | $78,184 | 13 | $214,186 | Jan 14 | Transeuropa | false |
| 18 | It's Complicated | - | - | - | $64,103 | 29 | $243,953 | Jan 28 | United International Pictures | false |
| 19 | The Twilight Saga: New Moon | - | - | - | $63,464 | 69 | $2,478,548 | Nov 26 | - | false |
| 20 | Ninja Assassin | - | - | - | $34,734 | 23 | $93,442 | Jan 28 | Warner Bros. | false |
| 21 | Happy-Go-Lucky | - | - | - | $30,144 | 3 | $66,723 | Dec 10 | - | false |
| 22 | The Imaginarium of Doctor Parnassus | - | - | - | $22,730 | 6 | $90,374 | Jan 28 | Sony Pictures Releasing | false |
| 23 | An Education | - | - | - | $20,387 | 5 | $27,571 | Jan 21 | Sony Pictures Releasing | false |
| 24 | Two Lovers | - | - | - | $17,900 | 9 | $54,356 | Jan 28 | - | false |
| 25 | Planet 51 | - | - | - | $17,136 | 24 | $271,297 | Nov 26 | - | false |
| 26 | The Reader | - | - | - | $5,891 | 16 | $87,013 | Dec 3 | - | false |
| 27 | Whiteout | - | - | - | $3,562 | 23 | $147,011 | Dec 3 | Warner Bros. | false |
| 28 | Inglourious Basterds | - | - | - | $2,720 | 35 | $900,805 | Oct 8 | United International Pictures | false |
| 29 | I've Loved You So Long | - | - | - | $2,590 | 4 | $63,427 | Nov 19 | Transeuropa | false |
| 30 | A Christmas Carol | - | - | - | $1,924 | 56 | $728,147 | Nov 5 | Walt Disney Pictures | false |
| 31 | The Merry Widow | - | - | - | $1,677 | 5 | $18,646 | Dec 10 | Transeuropa | false |
