| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Avatar | - | - | - | $8,795,750 | 148 | $13,778,096 | Jan 1 | 20th Century Fox International | false |
| 2 | Sherlock Holmes | - | - | - | $1,785,385 | 97 | $2,701,752 | Jan 14 | Warner Bros. | false |
| 3 | The Princess and the Frog | - | - | - | $1,586,570 | 103 | $1,922,032 | Jan 7 | Walt Disney Pictures | false |
| 4 | It's Complicated | - | - | - | $1,034,177 | 63 | $1,311,574 | Jan 7 | Universal Pictures International (UPI) | false |
| 5 | 2012 | - | - | - | $620,449 | 142 | $4,040,705 | Dec 3 | Sony Pictures Releasing | false |
| 6 | Old Dogs | - | - | - | $582,575 | 68 | $1,506,322 | Jan 21 | Walt Disney Pictures | false |
| 7 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $501,673 | 98 | $1,090,189 | Jan 21 | 20th Century Fox International | false |
| 8 | Up in the Air | - | - | - | $411,601 | 50 | $722,249 | Jan 21 | Paramount Pictures International | false |
| 9 | Paranormal Activity | - | - | - | $382,272 | 62 | $1,272,176 | Dec 10 | Distribution Company | false |
| 10 | Daybreakers | - | - | - | $228,370 | 37 | $388,845 | Jan 21 | Distribution Company | false |
| 11 | Invictus | - | - | - | $227,602 | 52 | $981,517 | Jan 28 | Warner Bros. | false |
| 12 | The Young Victoria | - | - | - | $141,603 | 25 | $182,531 | Jan 14 | Distribution Company | false |
| 13 | Le code a changé | - | - | - | $134,221 | 19 | $135,715 | Jan 1 | Alfa Films | false |
| 14 | Spread | - | - | - | $120,235 | 33 | $121,929 | Jan 1 | Impacto Cine | false |
| 15 | Ninja Assassin | - | - | - | $109,077 | 26 | $131,003 | Jan 7 | Warner Bros. | false |
| 16 | Nine | - | - | - | $108,621 | 25 | $268,101 | Jan 28 | Sony Pictures Releasing | false |
| 17 | Planet 51 | - | - | - | $97,429 | 58 | $179,380 | Nov 26 | CDI Films | false |
| 18 | Easy Virtue | - | - | - | $88,519 | 14 | $106,464 | Jan 14 | Sony Pictures Releasing | false |
| 19 | The Twilight Saga: New Moon | - | - | - | $79,746 | 117 | $3,302,766 | Nov 19 | Alfa Films | false |
| 20 | 500 Days of Summer | - | - | - | $56,119 | 15 | $358,052 | Nov 19 | 20th Century Fox International | false |
| 21 | A Christmas Carol | - | - | - | $50,542 | 110 | $1,947,233 | Nov 26 | Walt Disney Pictures | false |
| 22 | Astro Boy | - | - | - | $49,620 | 29 | $174,796 | Jan 28 | Alfa Films | false |
| 23 | The Secret in Their Eyes | - | - | - | $49,191 | 90 | $9,255,067 | Aug 13 | Distribution Company | false |
| 24 | Zombieland | - | - | - | $41,097 | 20 | $107,716 | Jan 28 | Sony Pictures Releasing | false |
| 25 | Two Lovers | - | - | - | $38,983 | 21 | $394,416 | Nov 19 | Distribution Company | false |
| 26 | Halloween II | - | - | - | $35,320 | 36 | $119,236 | Jan 7 | Distribution Company | false |
| 27 | Let the Right One In | - | - | - | $33,429 | 12 | $172,087 | Dec 3 | Pachamama Cine | false |
| 28 | Whiteout | - | - | - | $25,941 | 32 | $449,725 | Nov 12 | Warner Bros. | false |
| 29 | Nora's Will | - | - | - | $16,714 | 11 | $53,724 | Jan 28 | Primer Plano Film Group | false |
| 30 | Departures | - | - | - | $16,124 | 5 | $20,037 | Jan 14 | Alfa Films | false |
| 31 | Jellyfish 2010 Re-release | - | - | - | $15,218 | 5 | $24,761 | Jan 21 | - | false |
| 32 | My Stars | - | - | - | $14,205 | 20 | $101,672 | Dec 24 | Distribution Company | false |
| 33 | Let it Rain | - | - | - | $13,595 | 18 | $140,668 | Dec 10 | Alfa Films | false |
| 34 | Cloudy with a Chance of Meatballs | - | - | - | $8,150 | 71 | $1,667,186 | Oct 1 | Sony Pictures Releasing | false |
| 35 | Igor | - | - | - | $7,646 | 36 | $94,999 | Dec 3 | Distribution Company | false |
| 36 | Eden Lake | - | - | - | $7,245 | 18 | $65,011 | Dec 17 | CDI Films | false |
| 37 | The Appeared | - | - | - | $5,597 | 11 | $52,046 | Dec 3 | Primer Plano Film Group | false |
| 38 | The Widows of Thursdays | - | - | - | $5,151 | 80 | $1,999,017 | Sep 10 | Alfa Films | false |
| 39 | Grbavica 2009 Re-release | - | - | - | $4,645 | 6 | $23,859 | Dec 10 | - | false |
| 40 | Broken Embraces | - | - | - | $4,356 | 35 | $515,741 | Oct 1 | Universal Pictures International (UPI) | false |
| 41 | Paris 36 | - | - | - | $4,312 | 14 | $101,821 | Nov 5 | Alfa Films | false |
| 42 | A Matter of Principles | - | - | - | $3,321 | 36 | $581,219 | Sep 24 | - | false |
| 43 | Surrogates | - | - | - | $2,539 | 49 | $826,572 | Oct 22 | Walt Disney Pictures | false |
| 44 | Acne | - | - | - | $1,962 | 2 | $3,839 | Jan 7 | Primer Plano Film Group | false |
| 45 | Goodbye Solo | - | - | - | $1,822 | 6 | $39,010 | Nov 19 | IFA | false |
| 46 | Welcome to the Sticks | - | - | - | $1,398 | 21 | $155,242 | Oct 15 | Distribution Company | false |
| 47 | Lemon Tree | - | - | - | $1,325 | 11 | $117,698 | Oct 29 | Distribution Company | false |
| 48 | Inglourious Basterds | - | - | - | $1,246 | 56 | $1,216,394 | Sep 3 | Universal Pictures International (UPI) | false |
| 49 | [Rec]² | - | - | - | $1,210 | 27 | $303,775 | Oct 29 | CDI Films | false |
| 50 | Cartas para Jenny | - | - | - | $496 | 8 | $9,899 | Dec 10 | Primer Plano Film Group | false |
| 51 | The Burning Plain | - | - | - | $434 | 14 | $90,687 | Nov 5 | Impacto Cine | false |
| 52 | Saw VI | - | - | - | $393 | 58 | $654,417 | Nov 5 | Walt Disney Pictures | false |
| 53 | Youth Without Youth | - | - | - | $334 | 7 | $10,963 | Dec 17 | Distribution Company | false |
| 54 | The Brothers Bloom | - | - | - | $330 | 17 | $151,151 | Oct 22 | Alfa Films | false |
| 55 | The Tango Singer | - | - | - | $47 | 1 | $2,549 | Nov 5 | - | false |
