| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Yes Man | - | - | - | $2,661,338 | 88 | $3,719,800 | Jan 8 | Warner Bros. | false |
| 2 | Winter in Wartime | - | - | - | $2,656,728 | 102 | $8,089,289 | Nov 27 | Benelux Film Distributors | false |
| 3 | Australia | - | - | - | $2,148,254 | 105 | $4,508,197 | Dec 18 | Warner Bros. | false |
| 4 | Valkyrie | - | - | - | $1,787,021 | 98 | $3,794,826 | Jan 22 | Warner Bros. | false |
| 5 | Madagascar: Escape 2 Africa | - | - | - | $1,613,886 | 192 | $8,604,006 | Nov 20 | Universal Pictures International (UPI) | false |
| 6 | The Silent Army | - | - | - | $1,095,503 | 92 | $2,775,642 | Dec 11 | Independent Films | false |
| 7 | High School Musical 3: Senior Year | - | - | - | $876,404 | 115 | $2,735,772 | Dec 11 | Walt Disney Pictures | false |
| 8 | Bedtime Stories | - | - | - | $811,113 | 60 | $1,337,412 | Dec 25 | Walt Disney Pictures | false |
| 9 | The Curious Case of Benjamin Button | - | - | - | $679,643 | 91 | $4,157,439 | Jan 29 | Warner Bros. | false |
| 10 | Seven Pounds | - | - | - | $615,327 | 41 | $826,954 | Jan 15 | Sony Pictures Releasing | false |
| 11 | Vicky Cristina Barcelona | - | - | - | $486,591 | 26 | $1,262,493 | Dec 11 | Cinéart | false |
| 12 | The Day the Earth Stood Still | - | - | - | $478,845 | 96 | $2,188,225 | Dec 11 | Warner Bros. | false |
| 13 | Quantum of Solace | - | - | - | $429,916 | 135 | $8,891,362 | Nov 6 | Sony Pictures Releasing | false |
| 14 | Righteous Kill | - | - | - | $387,926 | 30 | $464,482 | Jan 8 | Moonlight Films | false |
| 15 | Revolutionary Road | - | - | - | $383,246 | 44 | $722,526 | Jan 22 | Universal Pictures International (UPI) | false |
| 16 | Bride Flight | - | - | - | $382,248 | 97 | $3,466,891 | Oct 16 | A-Film Distribution | false |
| 17 | Twilight | - | - | - | $370,407 | 60 | $1,294,203 | Dec 4 | Independent Films | false |
| 18 | Saw V | - | - | - | $302,965 | 58 | $458,431 | Jan 8 | Benelux Film Distributors | false |
| 19 | The Boy in the Striped Pajamas | - | - | - | $227,507 | 28 | $232,569 | Jan 8 | Walt Disney Pictures | false |
| 20 | The Flight Before Christmas | - | - | - | $207,442 | 66 | $708,440 | Dec 18 | RCV Film Distribution | false |
| 21 | Changeling | - | - | - | $207,076 | 30 | $712,343 | Dec 4 | Universal Pictures International (UPI) | false |
| 22 | Piet Piraat en het zwaard van Zilvertand | - | - | - | $207,053 | 75 | $484,913 | Dec 17 | Independent Films | false |
| 23 | Four Christmases | - | - | - | $204,467 | 33 | $649,706 | Dec 18 | Warner Bros. | false |
| 24 | Zack and Miri Make a Porno | - | - | - | $182,660 | 55 | $250,980 | Jan 22 | Benelux Film Distributors | false |
| 25 | The Class | - | - | - | $171,586 | 19 | $642,726 | Nov 27 | Cinéart | false |
| 26 | Milk | - | - | - | $139,019 | 21 | $554,412 | Jan 22 | A-Film Distribution | false |
| 27 | Gomorrah | - | - | - | $117,299 | 24 | $725,714 | Jan 29 | Cinemien | false |
| 28 | Frost/Nixon | - | - | - | $105,210 | 29 | $145,778 | Jan 15 | Universal Pictures International (UPI) | false |
| 29 | Burn After Reading | - | - | - | $75,659 | 46 | $1,820,048 | Oct 30 | Universal Pictures International (UPI) | false |
| 30 | CC2C | - | - | - | $70,768 | 6 | $70,768 | Jan 15 | Warner Bros. | false |
| 31 | The Visitor | - | - | - | $63,993 | 8 | $65,999 | Jan 8 | Wild Bunch Distribution | false |
| 32 | Body of Lies | - | - | - | $51,105 | 60 | $1,097,269 | Nov 20 | Warner Bros. | false |
| 33 | Mesrine: Killer Instinct | - | - | - | $43,926 | 30 | $87,252 | Jan 15 | A-Film Distribution | false |
| 34 | Anubis en het Pad der 7 Zonden | - | - | - | $33,690 | 112 | $4,610,038 | Oct 8 | Independent Films | false |
| 35 | The Goal of My Life | - | - | - | $24,657 | - | $34,054 | Jan 29 | - | false |
| 36 | Ghajini | - | - | - | $24,550 | - | $70,554 | Dec 25 | - | false |
| 37 | Pride and Glory | - | - | - | $20,423 | 30 | $242,024 | Dec 4 | RCV Film Distribution | false |
| 38 | Incendiary | - | - | - | $17,900 | 15 | $17,900 | Jan 15 | RCV Film Distribution | false |
| 39 | A Woman in Berlin | - | - | - | $13,289 | 14 | $13,289 | Jan 15 | A-Film Distribution | false |
| 40 | Hamlet 2 | - | - | - | $10,066 | 10 | $10,066 | Jan 15 | A-Film Distribution | false |
| 41 | Bloody Mondays & Strawberry Pies | - | - | - | $7,227 | 8 | $7,227 | Jan 8 | Cinéart | false |
| 42 | Can Go Through Skin | - | - | - | $6,675 | 7 | $7,359 | Jan 29 | Benelux Film Distributors | false |
| 43 | The Ramen Girl | - | - | - | $6,675 | 7 | $7,782 | Jan 29 | - | false |
| 44 | Versailles | - | - | - | $4,792 | 28 | $4,792 | Jan 2 | Benelux Film Distributors | false |
| 45 | The Song of Sparrows | - | - | - | $4,638 | 6 | $4,638 | Jan 8 | Cinemien | false |
| 46 | Youssou Ndour: I Bring What I Love | - | - | - | $4,378 | 6 | $4,378 | Jan 15 | Cinemien | false |
| 47 | 12 | - | - | - | $3,279 | 3 | $3,279 | Jan 15 | Filmmuseum Distributie | false |
| 48 | Captain Abu Raed | - | - | - | $1,979 | 6 | $1,979 | Jan 8 | A-Film Distribution | false |
| 49 | Links | - | - | - | $1,588 | 4 | $1,588 | Jan 22 | - | false |
| 50 | God's Offices | - | - | - | $1,166 | 3 | $1,166 | Jan 22 | Cinéart | false |
| 51 | Surveillance | - | - | - | $1,142 | 2 | $1,142 | Jan 8 | - | false |
| 52 | What Just Happened | - | - | - | $1,063 | 3 | $1,063 | Jan 8 | Paradiso Entertainment | false |
| 53 | Vinyan | - | - | - | $1,057 | 5 | $2,894 | Jan 29 | Moonlight Films | false |
| 54 | Standard Operating Procedure | - | - | - | $659 | 2 | $1,123 | Dec 18 | Sony Pictures Releasing | false |
