| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Seven Pounds | - | - | - | $13,746,893 | 553 | $16,157,223 | Jan 9 | Sony Pictures Releasing | false |
| 2 | Italians | - | - | - | $11,386,438 | 611 | $17,026,331 | Jan 23 | Filmauro | false |
| 3 | Yes Man | - | - | - | $9,454,098 | 349 | $10,187,158 | Jan 9 | Warner Bros. | false |
| 4 | Natale a Rio | - | - | - | $9,251,163 | 598 | $36,125,993 | Dec 19 | Filmauro | false |
| 5 | Journey to the Center of the Earth | - | - | - | $7,551,332 | 276 | $11,724,131 | Jan 16 | 01 Distribution | false |
| 6 | Madagascar: Escape 2 Africa | - | - | - | $6,053,158 | 583 | $34,915,869 | Dec 19 | Universal Pictures International (UPI) | false |
| 7 | Australia | - | - | - | $5,883,012 | 485 | $7,351,155 | Jan 16 | 20th Century Fox International | false |
| 8 | Il cosmo sul comò | - | - | - | $4,589,747 | 485 | $19,285,300 | Dec 19 | Medusa Distribuzione | false |
| 9 | Beverly Hills Chihuahua | - | - | - | $4,076,651 | 248 | $5,244,509 | Jan 16 | Walt Disney Pictures | false |
| 10 | Nights in Rodanthe | - | - | - | $3,090,708 | 316 | $8,805,990 | Dec 19 | Warner Bros. | false |
| 11 | The Strangers | - | - | - | $2,715,699 | 165 | $2,715,699 | Jan 2 | Universal Pictures International (UPI) | false |
| 12 | Easy Virtue | - | - | - | $2,688,475 | 142 | $3,590,951 | Jan 9 | Eagle Pictures | false |
| 13 | Valkyrie | - | - | - | $2,099,233 | 394 | $6,094,571 | Jan 30 | 01 Distribution | false |
| 14 | Twilight | - | - | - | $1,837,021 | 551 | $14,410,854 | Nov 21 | Eagle Pictures | false |
| 15 | Milk | - | - | - | $1,701,073 | 174 | $3,202,523 | Jan 23 | BIM Distribuzione | false |
| 16 | Slumdog Millionaire | - | - | - | $1,665,273 | 160 | $9,341,549 | Dec 5 | Lucky Red | false |
| 17 | The Boy in the Striped Pajamas | - | - | - | $1,646,729 | 103 | $3,802,419 | Dec 19 | Walt Disney Pictures | false |
| 18 | Revolutionary Road | - | - | - | $1,586,874 | 281 | $4,832,138 | Jan 30 | Universal Pictures International (UPI) | false |
| 19 | The Duchess | - | - | - | $1,314,869 | 202 | $2,901,441 | Dec 24 | BIM Distribuzione | false |
| 20 | Imago mortis | - | - | - | $1,020,042 | 163 | $1,020,042 | Jan 16 | Medusa Distribuzione | false |
| 21 | Defiance | - | - | - | $1,012,627 | 188 | $1,224,839 | Jan 23 | Medusa Distribuzione | false |
| 22 | The Spirit | - | - | - | $829,594 | 227 | $2,896,985 | Dec 26 | Sony Pictures Releasing | false |
| 23 | The Visitor | - | - | - | $803,267 | 57 | $2,194,531 | Dec 5 | Bolero Film | false |
| 24 | Lemon Tree | - | - | - | $743,258 | 47 | $1,471,720 | Dec 12 | Teodora Film | false |
| 25 | Waltz with Bashir | - | - | - | $740,032 | 44 | $1,041,913 | Jan 9 | Lucky Red | false |
| 26 | Doubt | - | - | - | $655,553 | 155 | $2,302,842 | Jan 30 | Walt Disney Pictures | false |
| 27 | Let the Right One In | - | - | - | $630,879 | 132 | $654,551 | Jan 9 | Bolero Film | false |
| 28 | Lissi und der wilde Kaiser | - | - | - | $569,368 | 156 | $597,954 | Jan 2 | Moviemax | false |
| 29 | As God Commands | - | - | - | $554,802 | 261 | $4,496,101 | Dec 12 | 01 Distribution | false |
| 30 | Four Christmases | - | - | - | $484,093 | 123 | $526,291 | Jan 23 | Warner Bros. | false |
| 31 | Whisper | - | - | - | $449,392 | 73 | $502,464 | Jan 23 | Eagle Pictures | false |
| 32 | The Life Before Her Eyes | - | - | - | $389,496 | 82 | $392,276 | Jan 2 | Mediafilm | false |
| 33 | Appaloosa | - | - | - | $286,903 | 37 | $387,450 | Jan 16 | 01 Distribution | false |
| 34 | City of Ember | - | - | - | $240,677 | 139 | $1,618,068 | Dec 19 | Eagle Pictures | false |
| 35 | The Day the Earth Stood Still | - | - | - | $221,245 | 448 | $6,037,792 | Dec 12 | 20th Century Fox International | false |
| 36 | Stella | - | - | - | $218,844 | 19 | $491,218 | Dec 5 | Sacher Distribuzione | false |
| 37 | Happy-Go-Lucky | - | - | - | $214,293 | 75 | $1,214,552 | Dec 5 | Mikado Film | false |
| 38 | Changeling | - | - | - | $204,840 | 299 | $6,693,283 | Nov 14 | Universal Pictures International (UPI) | false |
| 39 | Empties | - | - | - | $188,685 | 23 | $428,775 | Jan 16 | Fandango | false |
| 40 | Tony Manero | - | - | - | $148,067 | 16 | $171,645 | Jan 16 | Ripley's Film | false |
| 41 | Welcome to the Sticks | - | - | - | $144,643 | 325 | $4,245,593 | Oct 31 | Medusa Distribuzione | false |
| 42 | Comme les autres | - | - | - | $86,328 | 17 | $194,742 | Dec 19 | Archibald | false |
| 43 | Quarantine | - | - | - | $42,255 | 10 | $63,140 | Jan 30 | Sony Pictures Releasing | false |
| 44 | Giovanna's Father | - | - | - | $39,227 | 357 | $4,846,636 | Sep 12 | Medusa Distribuzione | false |
| 45 | Home | - | - | - | $31,251 | 17 | $159,990 | Jan 30 | Teodora Film | false |
| 46 | The Early Bird Catches the Worm | - | - | - | $23,026 | 253 | $1,550,893 | Feb 29 | Medusa Distribuzione | false |
| 47 | Rachel Getting Married | - | - | - | $22,998 | 20 | $288,409 | Nov 21 | Sony Pictures Releasing | false |
| 48 | Márió, a varázsló | - | - | - | $18,772 | 12 | $238,776 | Nov 28 | L'Altrofilm | false |
| 49 | W. | - | - | - | $12,689 | 3 | $28,684 | Dec 18 | - | false |
| 50 | Mar nero | - | - | - | $11,524 | 10 | $128,060 | Jan 30 | - | false |
| 51 | A Christmas Tale | - | - | - | $11,458 | 39 | $232,740 | Dec 5 | BIM Distribuzione | false |
| 52 | WALL·E | - | - | - | $8,556 | 592 | $12,210,993 | Oct 17 | Walt Disney Pictures | false |
| 53 | Vicky Cristina Barcelona | - | - | - | $5,092 | 383 | $8,124,300 | Oct 17 | Medusa Distribuzione | false |
| 54 | The Fox and the Child | - | - | - | $3,242 | 240 | $2,400,103 | Mar 21 | Lucky Red | false |
| 55 | Madagascar | - | - | - | $2,859 | 470 | $28,044,781 | Sep 2 | United International Pictures | false |
| 56 | Tutta la vita davanti | - | - | - | $2,188 | 368 | $5,648,340 | Mar 28 | Medusa Distribuzione | false |
| 57 | The Counterfeiters | - | - | - | $2,011 | 21 | $349,800 | Jan 25 | Lady Film | false |
| 58 | Beket | - | - | - | $1,930 | 2 | $6,482 | Jan 23 | - | false |
| 59 | I Only Wanted to Live | - | - | - | $1,916 | 1 | $28,847 | Jan 27 | 01 Distribution | false |
| 60 | The Sea Inside | - | - | - | $1,912 | 54 | $622,890 | Sep 4 | - | false |
| 61 | Gomorrah | - | - | - | $1,753 | 441 | $17,665,830 | May 16 | 01 Distribution | false |
| 62 | Se chiudi gli occhi | - | - | - | $1,641 | 2 | $16,255 | Nov 28 | A.B. Film | false |
| 63 | The Hanging Garden | - | - | - | $1,274 | 2 | $23,871 | Aug 27 | Mikado Film | false |
| 64 | Trick or Treaters | - | - | - | $973 | 74 | $124,488 | Nov 7 | BIM Distribuzione | false |
| 65 | The Kite Runner | - | - | - | $854 | 371 | $12,730,140 | Mar 28 | Filmauro | false |
| 66 | The Chronicles of Narnia: Prince Caspian | - | - | - | $835 | 601 | $10,800,873 | Aug 14 | Walt Disney Pictures | false |
| 67 | Kung Fu Panda | - | - | - | $800 | 669 | $22,037,818 | Aug 29 | Universal Pictures International (UPI) | false |
| 68 | Hoodwinked | - | - | - | $762 | 168 | $1,768,995 | Jun 1 | 01 Distribution | false |
| 69 | The Band's Visit | - | - | - | $706 | 51 | $919,800 | Mar 21 | Mikado Film | false |
| 70 | In Bruges | - | - | - | $617 | 151 | $772,903 | May 16 | Mikado Film | false |
| 71 | Donkey Xote | - | - | - | $609 | 69 | $70,295 | Oct 31 | - | false |
| 72 | Mid-August Lunch | - | - | - | $579 | 116 | $3,083,179 | Sep 3 | Fandango | false |
| 73 | High School Musical 3: Senior Year | - | - | - | $550 | 493 | $12,738,501 | Oct 31 | Walt Disney Pictures | false |
| 74 | Noah's Ark | - | - | - | $328 | 233 | $1,056,897 | Oct 3 | Eagle Pictures | false |
| 75 | Andres and me | - | - | - | $293 | 1 | $49,196 | Apr 11 | - | false |
| 76 | Passengers | - | - | - | $55 | 103 | $758,564 | Dec 5 | Moviemax | false |
