| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Aliens vs. Predator: Requiem | - | - | - | $770,380 | 51 | $1,353,607 | Jan 1 | - | false |
| 2 | I Am Legend | - | - | - | $676,697 | 53 | $2,209,266 | Dec 25 | - | false |
| 3 | Cloverfield | - | - | - | $634,412 | 29 | $691,130 | Jan 17 | - | false |
| 4 | National Treasure: Book of Secrets | - | - | - | $445,365 | 53 | $2,267,256 | Dec 20 | - | false |
| 5 | American Gangster | - | - | - | $416,626 | 24 | $501,580 | Jan 10 | - | false |
| 6 | Rambo | - | - | - | $389,192 | 39 | $688,493 | Jan 24 | - | false |
| 7 | One Missed Call | - | - | - | $332,417 | 26 | $334,649 | Jan 10 | - | false |
| 8 | 27 Dresses | - | - | - | $327,650 | 27 | $692,024 | Jan 24 | - | false |
| 9 | The Mist | - | - | - | $224,036 | 21 | $350,661 | Jan 24 | - | false |
| 10 | Body | - | - | - | $210,808 | 18 | $261,987 | Jan 10 | - | false |
| 11 | Alvin and the Chipmunks | - | - | - | $201,866 | 31 | $1,981,081 | Dec 13 | - | false |
| 12 | Le Grand Chef | - | - | - | $187,451 | 15 | $216,374 | Jan 10 | - | false |
| 13 | The Warlords | - | - | - | $108,685 | 38 | $1,557,155 | Dec 13 | - | false |
| 14 | Dan in Real Life | - | - | - | $103,361 | 11 | $122,145 | Jan 10 | - | false |
| 15 | Michael Clayton | - | - | - | $88,818 | 5 | $115,091 | Jan 3 | - | false |
| 16 | The House | - | - | - | $87,348 | 18 | $154,414 | Jan 24 | - | false |
| 17 | Eastern Promises | - | - | - | $87,076 | 6 | $94,020 | Jan 3 | - | false |
| 18 | Atonement | - | - | - | $71,565 | 10 | $138,007 | Jan 24 | - | false |
| 19 | Enchanted | - | - | - | $68,354 | 42 | $2,126,303 | Nov 22 | - | false |
| 20 | The Darjeeling Limited | - | - | - | $63,237 | 4 | $63,237 | Jan 3 | - | false |
| 21 | Elizabeth: The Golden Age | - | - | - | $61,789 | 9 | $122,256 | Dec 27 | - | false |
| 22 | Lust, Caution | - | - | - | $51,916 | 20 | $1,143,184 | Oct 4 | - | false |
| 23 | My Blueberry Nights | - | - | - | $37,033 | 4 | $62,202 | Dec 27 | - | false |
| 24 | Across the Universe | - | - | - | $35,525 | 3 | $53,702 | Dec 27 | - | false |
| 25 | The Golden Compass | - | - | - | $27,309 | 64 | $1,993,950 | Dec 6 | - | false |
| 26 | Linger | - | - | - | $26,703 | 8 | $27,824 | Jan 10 | - | false |
| 27 | Vexille | - | - | - | $23,835 | 1 | $32,712 | Dec 27 | - | false |
| 28 | Boogeyman 2 | - | - | - | $23,309 | 2 | $23,309 | Jan 3 | - | false |
| 29 | 3:10 to Yuma | - | - | - | $20,533 | 4 | $24,170 | Jan 17 | - | false |
| 30 | The Savages | - | - | - | $19,643 | 3 | $20,943 | Jan 17 | - | false |
| 31 | The Assassination of Jesse James by the Coward Robert Ford | - | - | - | $18,305 | 4 | $27,028 | Jan 24 | - | false |
| 32 | The Flock | - | - | - | $17,961 | 4 | $18,737 | Jan 17 | - | false |
| 33 | Penny Dreadful | - | - | - | $17,368 | 11 | $17,368 | Jan 3 | - | false |
| 34 | Trade | - | - | - | $15,066 | 1 | $17,147 | Jan 10 | - | false |
| 35 | Love in the Time of Cholera | - | - | - | $14,492 | 3 | $15,235 | Jan 10 | - | false |
| 36 | Redline | - | - | - | $11,353 | 11 | $92,685 | Dec 20 | - | false |
| 37 | Nanking | - | - | - | $10,102 | 1 | $67,581 | Dec 6 | - | false |
| 38 | Death Sentence | - | - | - | $9,804 | 3 | $14,170 | Jan 24 | - | false |
| 39 | Sharkwater | - | - | - | $8,970 | 3 | $12,237 | Jan 17 | - | false |
| 40 | Mr. Magorium's Wonder Emporium | - | - | - | $8,236 | 18 | $302,923 | Dec 13 | - | false |
| 41 | Reservation Road | - | - | - | $7,563 | 3 | $7,563 | Jan 3 | - | false |
