| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Enchanted | - | - | - | $2,296,468 | 108 | $2,862,455 | Jan 3 | Walt Disney Pictures | false |
| 2 | I Am Legend | - | - | - | $1,767,579 | 91 | $2,075,757 | Dec 27 | Warner Bros. | false |
| 3 | National Treasure: Book of Secrets | - | - | - | $1,089,203 | 90 | $1,701,941 | Jan 17 | Walt Disney Pictures | false |
| 4 | Saw IV | - | - | - | $886,801 | 63 | $1,012,487 | Nov 1 | Walt Disney Pictures | false |
| 5 | American Gangster | - | - | - | $661,427 | 54 | $793,526 | Jan 3 | United International Pictures | false |
| 6 | Alvin and the Chipmunks | - | - | - | $593,574 | 69 | $833,808 | Jan 3 | 20th Century Fox International | false |
| 7 | The Golden Compass | - | - | - | $503,726 | 84 | $1,421,819 | Dec 13 | Distribution Company | false |
| 8 | Aliens vs. Predator: Requiem | - | - | - | $499,469 | 41 | $708,036 | Jan 10 | 20th Century Fox International | false |
| 9 | Charlie Wilson's War | - | - | - | $339,637 | 45 | $872,501 | Jan 24 | United International Pictures | false |
| 10 | I Could Never Be Your Woman | - | - | - | $278,685 | 34 | $302,572 | Jan 3 | CDI Films | false |
| 11 | Love in the Time of Cholera | - | - | - | $261,939 | 33 | $603,059 | Jan 17 | 20th Century Fox International | false |
| 12 | The Simpsons Movie | - | - | - | $252,394 | 182 | $7,562,798 | Jul 26 | 20th Century Fox International | false |
| 13 | Bee Movie | - | - | - | $218,950 | 101 | $1,481,104 | Dec 6 | United International Pictures | false |
| 14 | The Heartbreak Kid | - | - | - | $191,593 | 33 | $914,034 | Nov 8 | United International Pictures | false |
| 15 | Sleuth | - | - | - | $127,247 | 12 | $166,205 | Jan 10 | Sony Pictures Releasing | false |
| 16 | 1408 | - | - | - | $125,992 | 37 | $262,789 | Jan 24 | United International Pictures | false |
| 17 | My Best Friend | - | - | - | $106,854 | 16 | $123,823 | Jan 3 | Alfa Films | false |
| 18 | Bridge to Terabithia | - | - | - | $92,778 | 36 | $101,169 | Jan 10 | United International Pictures | false |
| 19 | Hitman | - | - | - | $86,507 | 26 | $188,585 | Jan 24 | 20th Century Fox International | false |
| 20 | Gone Baby Gone | - | - | - | $74,059 | 21 | $436,926 | Nov 22 | Walt Disney Pictures | false |
| 21 | August Rush | - | - | - | $69,467 | 42 | $70,284 | Jan 10 | Distribution Company | false |
| 22 | Giants of Valdes | - | - | - | $68,904 | 33 | $84,495 | Jan 17 | Primer Plano Film Group | false |
| 23 | Beowulf | - | - | - | $59,572 | 47 | $904,033 | Nov 22 | Warner Bros. | false |
| 24 | Bordertown | - | - | - | $55,774 | 32 | $60,948 | Jan 17 | Distribution Company | false |
| 25 | 4 Months, 3 Weeks and 2 Days | - | - | - | $49,651 | 12 | $203,767 | Dec 6 | Pachamama Cine | false |
| 26 | Superbad | - | - | - | $34,685 | 30 | $396,284 | Nov 22 | Sony Pictures Releasing | false |
| 27 | The Flock | - | - | - | $32,317 | 30 | $187,463 | Dec 6 | CDI Films | false |
| 28 | I Do: How to Get Married and Stay Single | - | - | - | $31,392 | 7 | $71,375 | Jan 24 | Alfa Films | false |
| 29 | Lions for Lambs | - | - | - | $28,014 | 42 | $509,908 | Nov 15 | 20th Century Fox International | false |
| 30 | The Assassination of Jesse James by the Coward Robert Ford | - | - | - | $23,778 | 15 | $158,043 | Nov 29 | Warner Bros. | false |
| 31 | Retribution | - | - | - | $22,165 | 20 | $115,072 | Dec 13 | Pachamama Cine | false |
| 32 | The Hitcher | - | - | - | $21,385 | 30 | $138,291 | Dec 6 | Distribution Company | false |
| 33 | Days of Glory | - | - | - | $18,637 | 5 | $18,890 | Jan 3 | Alfa Films | false |
| 34 | Café Lumière 2007 Re-release | - | - | - | $18,123 | 3 | $51,258 | Dec 13 | 791 Cine | false |
| 35 | Who Says It's Easy? | - | - | - | $17,497 | 54 | $1,265,601 | Feb 8 | Primer Plano Film Group | false |
| 36 | The Bow | - | - | - | $13,377 | 3 | $931,554 | Jan 25 | Alfa Films | false |
| 37 | After the Wedding | - | - | - | $12,182 | 11 | $107,601 | Nov 22 | Alfa Films | false |
| 38 | Goya's Ghosts | - | - | - | $8,483 | 4 | $14,176 | Jan 24 | Alfa Films | false |
| 39 | Suspiros del corazón | - | - | - | $5,833 | 4 | $8,429 | Jan 10 | Primer Plano Film Group | false |
| 40 | The Black Dahlia | - | - | - | $4,623 | 6 | $62,360 | Nov 22 | United International Pictures | false |
| 41 | Lonely Hearts | - | - | - | $4,396 | 21 | $100,016 | Nov 29 | Distribution Company | false |
| 42 | Underdog | - | - | - | $2,959 | 46 | $886,546 | Oct 4 | Walt Disney Pictures | false |
| 43 | The Last Kiss | - | - | - | $2,939 | 12 | $48,271 | Dec 6 | United International Pictures | false |
| 44 | Black Book | - | - | - | $2,528 | 26 | $469,117 | Aug 23 | Pachamama Cine | false |
| 45 | Hechos, No Palabras | - | - | - | $2,490 | 1 | $2,749 | Jan 10 | Primer Plano Film Group | false |
| 46 | Resident Evil: Extinction | - | - | - | $2,385 | 30 | $550,303 | Oct 11 | Sony Pictures Releasing | false |
| 47 | Shattered | - | - | - | $2,026 | 36 | $324,918 | Nov 8 | Distribution Company | false |
| 48 | Estrellas | - | - | - | $1,735 | 5 | $14,426 | Dec 13 | Primer Plano Film Group | false |
| 49 | The Other | - | - | - | $1,716 | 14 | $118,075 | May 10 | Distribution Company | false |
| 50 | Halloween | - | - | - | $1,483 | 30 | $206,325 | Nov 8 | Alfa Films | false |
| 51 | Whisper | - | - | - | $1,437 | 28 | $112,121 | Nov 29 | Alfa Films | false |
| 52 | Vitus | - | - | - | $1,419 | 12 | $48,522 | Nov 15 | CDI Films | false |
| 53 | Shortbus | - | - | - | $1,403 | 5 | $30,712 | Nov 1 | Distribution Company | false |
| 54 | ¿De quién es el portaligas? | - | - | - | $1,346 | 36 | $86,948 | Sep 20 | Primer Plano Film Group | false |
| 55 | The 11th Hour | - | - | - | $1,010 | 6 | $14,124 | Dec 6 | Warner Bros. | false |
| 56 | Encarnacion | - | - | - | $937 | 9 | $41,526 | Oct 11 | Distribution Company | false |
| 57 | Quiéreme | - | - | - | $904 | 16 | $62,172 | Nov 15 | Alfa Films | false |
| 58 | A Stray Girlfriend | - | - | - | $886 | 12 | $48,453 | Jun 7 | Primer Plano Film Group | false |
| 59 | Lights in the Dusk | - | - | - | $808 | 22 | $52,423 | Sep 27 | Alfa Films | false |
| 60 | City in Heat | - | - | - | $598 | 3 | $32,697 | Mar 22 | Alfa Films | false |
| 61 | Next | - | - | - | $567 | 21 | $319,515 | Sep 27 | United International Pictures | false |
| 62 | The Death of Mr. Lazarescu | - | - | - | $498 | 2 | $22,819 | Jan 4 | Zeta Films | false |
| 63 | La señal | - | - | - | $362 | 64 | $1,096,646 | Sep 13 | Walt Disney Pictures | false |
| 64 | Hacer patria | - | - | - | $301 | 4 | $9,149 | Aug 9 | Distribution Company | false |
| 65 | The Painted Veil | - | - | - | $234 | 22 | $364,235 | Oct 4 | Distribution Company | false |
| 66 | Family Hero | - | - | - | $190 | 21 | $190,119 | Sep 27 | Pachamama Cine | false |
| 67 | The Seeker: The Dark Is Rising | - | - | - | $188 | 28 | $150,262 | Nov 1 | 20th Century Fox International | false |
| 68 | Knocked Up | - | - | - | $170 | 23 | $186,229 | Oct 18 | United International Pictures | false |
| 69 | El resultado del amor | - | - | - | $164 | 21 | $61,927 | Aug 16 | Primer Plano Film Group | false |
| 70 | The Aerial | - | - | - | $137 | 5 | $16,831 | Apr 19 | Pachamama Cine | false |
| 71 | Kept and Dreamless | - | - | - | $95 | 13 | $18,616 | Apr 26 | Primer Plano Film Group | false |
| 72 | Pueblo chico | - | - | - | $89 | 1 | $904 | Nov 29 | Primer Plano Film Group | false |
| 73 | The Invasion | - | - | - | $67 | 29 | $321,586 | Oct 4 | Warner Bros. | false |
| 74 | Sicko | - | - | - | $66 | 13 | $67,898 | Sep 20 | Alfa Films | false |
| 75 | Música nocturna | - | - | - | $61 | 4 | $25,650 | Nov 15 | Primer Plano Film Group | false |
| 76 | Ratatouille | - | - | - | $55 | 164 | $3,843,055 | Jul 5 | Buena Vista International | false |
| 77 | Incorregibles | - | - | - | $55 | 113 | $2,307,024 | Jul 5 | Argentina Sono Film S.A.C.I. | false |
| 78 | Argentina latente | - | - | - | $50 | 3 | $31,599 | May 24 | Primer Plano Film Group | false |
| 79 | Premonition | - | - | - | $42 | 33 | $537,519 | Sep 6 | Distribution Company | false |
| 80 | M | - | - | - | $41 | 3 | $5,279 | Aug 30 | 791 Cine | false |
| 81 | Isidoro, la película | - | - | - | $33 | 79 | $678,736 | Jul 5 | Pachamama Cine | false |
| 82 | When She Jumped | - | - | - | $29 | 8 | $6,541 | Nov 1 | Primer Plano Film Group | false |
| 83 | The Past | - | - | - | $17 | 19 | $61,970 | Nov 8 | 20th Century Fox International | false |
| 84 | Fotografías | - | - | - | $16 | 1 | $5,004 | Jun 14 | Primer Plano Film Group | false |
| 85 | Pulqui, un instante en la patria de la felicidad | - | - | - | $7 | 1 | $1,717 | Jul 12 | Primer Plano Film Group | false |
