| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Avatar | - | - | - | $110,807,652 | 3,461 | $749,766,139 | Dec 18 | Twentieth Century Fox | false |
| 2 | Valentine's Day | - | - | - | $99,916,240 | 3,665 | $110,485,654 | Feb 12 | Warner Bros. | false |
| 3 | Shutter Island | - | - | - | $75,541,271 | 3,356 | $128,012,934 | Feb 19 | Paramount Pictures | false |
| 4 | Dear John | - | - | - | $72,432,096 | 3,062 | $80,014,842 | Feb 5 | Screen Gems | false |
| 5 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $70,998,280 | 3,396 | $88,768,303 | Feb 12 | Twentieth Century Fox | false |
| 6 | The Wolfman | - | - | - | $57,380,125 | 3,223 | $61,979,680 | Feb 12 | Universal Pictures | false |
| 7 | Tooth Fairy | - | - | - | $27,737,067 | 3,345 | $60,022,256 | Jan 22 | Twentieth Century Fox | false |
| 8 | Edge of Darkness | - | - | - | $24,955,902 | 3,066 | $43,313,890 | Jan 29 | Warner Bros. | false |
| 9 | From Paris with Love | - | - | - | $23,324,666 | 2,722 | $24,077,427 | Feb 5 | Lionsgate Films | false |
| 10 | When in Rome | - | - | - | $18,511,614 | 2,456 | $32,680,633 | Jan 29 | Walt Disney Studios Motion Pictures | false |
| 11 | Crazy Heart | - | - | - | $18,352,117 | 1,361 | $39,464,306 | Dec 16 | - | false |
| 12 | Cop Out | - | - | - | $18,211,126 | 3,150 | $44,875,481 | Feb 26 | Warner Bros. | false |
| 13 | The Book of Eli | - | - | - | $17,995,190 | 3,111 | $94,835,059 | Jan 15 | Warner Bros. | false |
| 14 | The Crazies | - | - | - | $16,067,552 | 2,479 | $39,123,589 | Feb 26 | Overture Films | false |
| 15 | The Blind Side | - | - | - | $10,841,176 | 3,407 | $255,959,475 | Nov 20 | Warner Bros. | false |
| 16 | Legion | - | - | - | $10,627,072 | 2,476 | $40,168,080 | Jan 22 | Screen Gems | false |
| 17 | Sherlock Holmes | - | - | - | $8,817,726 | 3,626 | $209,028,679 | Dec 25 | Warner Bros. | false |
| 18 | Up in the Air | - | - | - | $8,805,260 | 2,218 | $83,823,381 | Dec 4 | Paramount Pictures | false |
| 19 | It's Complicated | - | - | - | $7,401,725 | 2,955 | $112,735,375 | Dec 25 | Universal Pictures | false |
| 20 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $7,261,984 | 3,747 | $219,614,612 | Dec 23 | Twentieth Century Fox | false |
| 21 | The Lovely Bones | - | - | - | $5,586,628 | 2,638 | $44,114,232 | Dec 11 | DreamWorks | false |
| 22 | My Name Is Khan | - | - | - | $3,634,423 | 125 | $4,018,771 | Feb 12 | - | false |
| 23 | The Princess and the Frog | - | - | - | $3,080,279 | 3,475 | $104,400,899 | Nov 25 | Walt Disney Studios Motion Pictures | false |
| 24 | The Spy Next Door | - | - | - | $2,729,037 | 2,924 | $24,307,086 | Jan 15 | Lionsgate Films | false |
| 25 | A Single Man | - | - | - | $2,674,396 | 354 | $9,176,000 | Dec 11 | The Weinstein Company | false |
| 26 | The Last Station | - | - | - | $2,673,600 | 354 | $6,617,867 | Jan 15 | Sony Pictures Classics | false |
| 27 | An Education | - | - | - | $2,647,945 | 763 | $12,574,914 | Oct 9 | Sony Pictures Classics | false |
| 28 | The Twilight Saga: New Moon | - | - | - | $2,196,773 | 4,124 | $296,623,634 | Nov 20 | Summit Entertainment | false |
| 29 | The Young Victoria | - | - | - | $1,904,683 | 476 | $11,001,272 | Dec 18 | Apparition | false |
| 30 | Precious | - | - | - | $1,661,736 | 1,003 | $47,566,524 | Nov 6 | Lionsgate Films | false |
| 31 | Extraordinary Measures | - | - | - | $1,622,745 | 2,549 | $12,068,313 | Jan 22 | CBS Films | false |
| 32 | To Save a Life | - | - | - | $1,165,785 | 441 | $3,777,210 | Jan 22 | The Samuel Goldwyn Company | false |
| 33 | Leap Year | - | - | - | $1,158,895 | 2,512 | $25,918,920 | Jan 8 | Universal Pictures | false |
| 34 | The Imaginarium of Doctor Parnassus | - | - | - | $1,115,631 | 607 | $7,689,607 | Dec 25 | Sony Pictures Classics | false |
| 35 | The Ghost Writer | - | - | - | $1,048,233 | 819 | $15,541,549 | Feb 19 | Summit Entertainment | false |
| 36 | Planet 51 | - | - | - | $946,236 | 3,035 | $42,194,060 | Nov 20 | Sony Pictures Releasing | false |
| 37 | Invictus | - | - | - | $896,980 | 2,170 | $37,491,364 | Dec 11 | Warner Bros. | false |
| 38 | The White Ribbon | - | - | - | $869,406 | 106 | $2,222,862 | Dec 30 | Sony Pictures Classics | false |
| 39 | Under the Sea 3D | - | - | - | $683,612 | 108 | $36,262,926 | Feb 13 | Warner Bros. | false |
| 40 | Daybreakers | - | - | - | $678,022 | 2,523 | $30,101,577 | Jan 8 | Lionsgate Films | false |
| 41 | 2012 | - | - | - | $659,994 | 3,444 | $166,112,167 | Nov 13 | Sony Pictures Releasing | false |
| 42 | Broken Embraces | - | - | - | $610,179 | 202 | $5,014,305 | Nov 20 | Sony Pictures Classics | false |
| 43 | The Oscar Nominated Short Films 2010: Live Action | - | - | - | $537,680 | 95 | $1,018,169 | Feb 19 | Shorts International | false |
| 44 | Fantastic Mr. Fox | - | - | - | $442,684 | 2,304 | $21,002,919 | Nov 13 | Twentieth Century Fox | false |
| 45 | Nine | - | - | - | $427,156 | 1,412 | $19,676,965 | Dec 18 | The Weinstein Company | false |
| 46 | Old Dogs | - | - | - | $384,042 | 3,425 | $49,492,060 | Nov 25 | Walt Disney Studios Motion Pictures | false |
| 47 | Space Station 3D | - | - | - | $376,856 | 64 | $93,383,953 | Apr 19 | IMAX | false |
| 48 | Magnificent Desolation: Walking on the Moon | - | - | - | $357,301 | 82 | $34,137,524 | Sep 23 | IMAX | false |
| 49 | Preacher's Kid | - | - | - | $349,790 | 109 | $515,065 | Jan 29 | 8x Entertainment | false |
| 50 | Youth in Revolt | - | - | - | $313,709 | 1,873 | $15,281,286 | Jan 8 | - | false |
| 51 | Frozen | - | - | - | $229,202 | 106 | $246,176 | Feb 5 | Anchor Bay Films | false |
| 52 | The Road | - | - | - | $224,148 | 396 | $8,117,000 | Nov 25 | - | false |
| 53 | North Face | - | - | - | $220,889 | 36 | $711,421 | Jan 29 | Music Box Films | false |
| 54 | Ajami | - | - | - | $220,498 | 23 | $622,403 | Feb 3 | Kino International | false |
| 55 | The Messenger | - | - | - | $169,680 | 50 | $1,109,660 | Nov 13 | Oscilloscope | false |
| 56 | Fish Tank | - | - | - | $146,202 | 15 | $374,675 | Jan 15 | IFC Films | false |
| 57 | The Most Dangerous Man in America: Daniel Ellsberg and the Pentagon Papers | - | - | - | $142,937 | 12 | $453,993 | Jan 29 | First Run | false |
| 58 | Creation | - | - | - | $140,430 | 12 | $341,323 | Jan 22 | Newmarket Films | false |
| 59 | 3 Idiots | - | - | - | $119,808 | 156 | $6,532,874 | Dec 23 | Reliance Big Pictures | false |
| 60 | Blood Done Sign My Name | - | - | - | $109,383 | 95 | $109,383 | Feb 19 | Paladin | false |
| 61 | A Prophet | - | - | - | $108,267 | 83 | $2,087,720 | Feb 26 | Sony Pictures Classics | false |
| 62 | Sea Monsters: A Prehistoric Adventure | - | - | - | $107,426 | 252 | $23,746,066 | Oct 5 | National Geographic Entertainment | false |
| 63 | Karthik Calling Karthik | - | - | - | $89,244 | 70 | $286,409 | Feb 26 | Eros Worldwide | false |
| 64 | Bad Lieutenant: Port of Call New Orleans | - | - | - | $88,068 | 96 | $1,702,112 | Nov 20 | First Look International | false |
| 65 | Saint John of Las Vegas | - | - | - | $86,471 | 14 | $102,645 | Jan 29 | IndieVest Pictures | false |
| 66 | Deep Sea | - | - | - | $81,622 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 67 | Ninja Assassin | - | - | - | $80,513 | 2,503 | $38,122,883 | Nov 25 | Warner Bros. | false |
| 68 | Terribly Happy | - | - | - | $76,690 | 9 | $170,943 | Feb 5 | Oscilloscope | false |
| 69 | That Evening Sun | - | - | - | $74,689 | 10 | $281,350 | Nov 6 | Freestyle Releasing | false |
| 70 | La Danse: The Paris Opera Ballet | - | - | - | $73,616 | 25 | $567,493 | Nov 4 | Zipporah Films | false |
| 71 | Veer | - | - | - | $72,291 | 92 | $527,193 | Jan 22 | Eros Worldwide | false |
| 72 | The Good Guy | - | - | - | $68,434 | 9 | $100,688 | Feb 19 | Roadside Attractions | false |
| 73 | Red Riding: The Year of Our Lord 1974 | - | - | - | $65,389 | 9 | $151,644 | Feb 5 | IFC Films | false |
| 74 | The Boondock Saints II: All Saints Day | - | - | - | $62,255 | 524 | $10,273,188 | Oct 30 | Apparition | false |
| 75 | Me and Orson Welles | - | - | - | $60,313 | 134 | $1,190,003 | Nov 25 | Freestyle Releasing | false |
| 76 | The Girl on the Train | - | - | - | $58,751 | 10 | $208,023 | Jan 22 | Strand Releasing | false |
| 77 | Where the Wild Things Are | - | - | - | $57,593 | 3,735 | $77,233,467 | Oct 16 | Warner Bros. | false |
| 78 | Dolphins and Whales 3D: Tribes of the Ocean | - | - | - | $56,932 | 42 | $7,714,996 | Feb 15 | 3D Entertainment | false |
| 79 | A Town Called Panic | - | - | - | $40,740 | 10 | $165,509 | Dec 16 | Zeitgeist Films | false |
| 80 | Formosa Betrayed | - | - | - | $40,233 | 16 | $225,341 | Feb 26 | Screen Media Films | false |
| 81 | Ran 2010 Re-release | - | - | - | $37,532 | 4 | $124,673 | Feb 5 | Rialto Pictures | false |
| 82 | The Secrets of Jonathan Sperry | - | - | - | $35,748 | 135 | $1,355,079 | Sep 18 | Five & Two Pictures | false |
| 83 | Defendor | - | - | - | $29,898 | 4 | $44,462 | Feb 19 | Darius Films | false |
| 84 | The Private Lives of Pippa Lee | - | - | - | $29,587 | 26 | $337,356 | Nov 27 | Screen Media Films | false |
| 85 | Until the Light Takes Us | - | - | - | $28,800 | 3 | $130,441 | Dec 4 | Variance Films | false |
| 86 | Couples Retreat | - | - | - | $28,730 | 3,074 | $109,204,945 | Oct 9 | Universal Pictures | false |
| 87 | District 13: Ultimatum | - | - | - | $28,511 | 9 | $36,136 | Feb 5 | Magnolia Pictures | false |
| 88 | House | - | - | - | $27,650 | 7 | $209,765 | Jan 15 | Janus Films | false |
| 89 | The Weathered Underground | - | - | - | $26,436 | 22 | $140,091 | Jan 26 | Indican Pictures | false |
| 90 | The Art of the Steal | - | - | - | $23,064 | 34 | $544,890 | Feb 26 | IFC Films | false |
| 91 | Coco Before Chanel | - | - | - | $22,335 | 307 | $6,113,834 | Sep 25 | Sony Pictures Classics | false |
| 92 | Eyes Wide Open | - | - | - | $21,957 | 1 | $26,258 | Feb 5 | New American Vision | false |
| 93 | The Yellow Handkerchief | - | - | - | $21,807 | 29 | $318,623 | Feb 26 | The Samuel Goldwyn Company | false |
| 94 | Happy Tears | - | - | - | $21,568 | 15 | $22,464 | Feb 19 | Roadside Attractions | false |
| 95 | Videocracy | - | - | - | $19,443 | 1 | $23,720 | Feb 12 | Kino International | false |
| 96 | 44 Inch Chest 2010 Re-release | - | - | - | $18,043 | 5 | $39,033 | Jan 15 | Image Entertainment | false |
| 97 | Red Cliff | - | - | - | $17,977 | 42 | $627,047 | Nov 18 | Magnolia Pictures | false |
| 98 | The Korean | - | - | - | $17,306 | 2 | $20,279 | Feb 5 | Indican Pictures | false |
| 99 | The Maid | - | - | - | $15,682 | 19 | $576,608 | Oct 16 | Elephant Eye Films | false |
| 100 | Killing Kasztner | - | - | - | $14,833 | 5 | $112,313 | Oct 23 | Sky Island Films | false |
| 101 | Law Abiding Citizen | - | - | - | $14,314 | 2,890 | $73,357,727 | Oct 16 | Overture Films | false |
| 102 | A Christmas Carol | - | - | - | $14,288 | 3,683 | $137,855,863 | Nov 6 | Walt Disney Studios Motion Pictures | false |
| 103 | October Country | - | - | - | $14,014 | 4 | $26,185 | Feb 12 | International Film Circuit | false |
| 104 | Seraphine | - | - | - | $13,490 | 24 | $884,613 | Jun 5 | Music Box Films | false |
| 105 | U2 3D | - | - | - | $12,936 | 686 | $10,363,341 | Jan 23 | National Geographic Entertainment | false |
| 106 | The Men Who Stare at Goats | - | - | - | $12,086 | 2,453 | $32,428,195 | Nov 6 | Overture Films | false |
| 107 | 35 Shots of Rum | - | - | - | $11,541 | 5 | $177,511 | Sep 16 | The Cinema Guild | false |
| 108 | The Yes Men Fix the World | - | - | - | $11,327 | 16 | $194,533 | Sep 25 | Shadow Distribution | false |
| 109 | Mystery Team | - | - | - | $10,788 | 4 | $89,442 | Aug 28 | Roadside Attractions | false |
| 110 | Off and Running | - | - | - | $9,264 | 1 | $18,262 | Jan 29 | First Run | false |
| 111 | The Wedding Song | - | - | - | $9,049 | 4 | $31,160 | Oct 9 | Strand Releasing | false |
| 112 | Shanghai Red 2010 Re-release | - | - | - | $8,659 | 3 | $30,353 | Feb 12 | Indican Pictures | false |
| 113 | The End of Poverty? | - | - | - | $6,721 | 5 | $57,805 | Nov 13 | Cinema Libre Studio | false |
| 114 | The Beaches of Agnès | - | - | - | $5,733 | 7 | $239,711 | Jul 2 | The Cinema Guild | false |
| 115 | Good Hair | - | - | - | $5,516 | 466 | $4,157,223 | Oct 9 | Roadside Attractions | false |
| 116 | Galapagos | - | - | - | $5,409 | 14 | $18,630,372 | Oct 29 | IMAX | false |
| 117 | Beeswax | - | - | - | $4,844 | 3 | $46,590 | Aug 7 | The Cinema Guild | false |
| 118 | The Sun 2009 Re-release | - | - | - | $4,788 | 4 | $77,303 | Nov 18 | Lorber Films | false |
| 119 | Four Seasons Lodge | - | - | - | $4,622 | 3 | $58,334 | Nov 11 | First Run | false |
| 120 | The Horse Boy | - | - | - | $4,487 | 5 | $156,612 | Sep 30 | Zeitgeist Films | false |
| 121 | The Cove | - | - | - | $3,766 | 56 | $857,005 | Jul 31 | Roadside Attractions | false |
| 122 | Waiting for Armageddon | - | - | - | $3,680 | 1 | $10,501 | Jan 8 | First Run | false |
| 123 | Youssou Ndour: I Bring What I Love | - | - | - | $3,666 | 7 | $172,225 | Jun 12 | Shadow Distribution | false |
| 124 | Prodigal Sons | - | - | - | $3,489 | 11 | $73,544 | Feb 26 | First Run | false |
| 125 | Crude | - | - | - | $3,154 | 7 | $170,295 | Sep 9 | First Run | false |
| 126 | The Damned United | - | - | - | $2,950 | 45 | $449,865 | Oct 9 | Sony Pictures Classics | false |
| 127 | Under Our Skin | - | - | - | $2,515 | 6 | $98,548 | Jun 19 | Shadow Distribution | false |
| 128 | Toe to Toe | - | - | - | $2,493 | 2 | $21,648 | Feb 26 | Strand Releasing | false |
| 129 | Promised Lands | - | - | - | $2,413 | 1 | $4,546 | Feb 5 | The Film Desk | false |
| 130 | Sweetgrass | - | - | - | $2,182 | 9 | $207,473 | Jan 6 | The Cinema Guild | false |
| 131 | Harlan: In the Shadow of Jew Suess | - | - | - | $2,052 | 5 | $54,305 | Mar 3 | Zeitgeist Films | false |
| 132 | Dreamkiller | - | - | - | $1,944 | 3 | $15,514 | Feb 19 | Delaware Pictures | false |
| 133 | The Headless Woman | - | - | - | $1,936 | 3 | $100,177 | Aug 19 | Strand Releasing | false |
| 134 | Harmony and Me | - | - | - | $1,882 | 1 | $20,099 | Sep 18 | - | false |
| 135 | Bliss 2009 Re-release | - | - | - | $1,632 | 3 | $40,349 | Aug 7 | First Run | false |
| 136 | Falling Awake | - | - | - | $1,615 | 2 | $1,978 | Jan 29 | IFC Films | false |
| 137 | Home | - | - | - | $1,497 | 2 | $15,925 | Nov 27 | Lorber Films | false |
| 138 | Cloud 9 | - | - | - | $1,254 | 8 | $91,675 | Aug 14 | Music Box Films | false |
| 139 | Departures | - | - | - | $1,101 | 27 | $1,498,210 | May 29 | Regent Releasing | false |
| 140 | Small Change | - | - | - | $1,047 | 2 | $38,296 | Nov 24 | The Film Desk | false |
| 141 | The September Issue | - | - | - | $1,012 | 143 | $3,820,067 | Aug 28 | Roadside Attractions | false |
| 142 | The Missing Person | - | - | - | $948 | 3 | $17,896 | Nov 20 | Strand Releasing | false |
| 143 | Shall We Kiss? | - | - | - | $814 | 33 | $535,499 | Mar 27 | Music Box Films | false |
| 144 | Mississippi Mermaid | - | - | - | $763 | 1 | $33,216 | Jul 10 | The Film Desk | false |
| 145 | Big Fan | - | - | - | $672 | 15 | $234,540 | Aug 28 | First Independent Pictures | false |
| 146 | Yuri Gagarin Conspiracy: Fallen Idol | - | - | - | $633 | 2 | $14,471 | Oct 2 | Indican Pictures | false |
| 147 | Monsieur Verdoux | - | - | - | $574 | 2 | $64,636 | Mar 14 | The Film Desk | false |
| 148 | Misconceptions | - | - | - | $392 | 2 | $6,892 | Jan 22 | Regent Releasing | false |
| 149 | Amreeka | - | - | - | $356 | 40 | $627,436 | Sep 4 | National Geographic Entertainment | false |
| 150 | Fashion Victim | - | - | - | $340 | 2 | $3,346 | Jan 22 | Regent Releasing | false |
| 151 | Watercolors | - | - | - | $312 | 2 | $6,305 | Jan 22 | Regent Releasing | false |
| 152 | 45365 | - | - | - | $198 | 1 | $853 | Feb 26 | - | false |
| 153 | Trucker | - | - | - | $148 | 13 | $52,429 | Oct 9 | Monterey Media | false |
