| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Avatar | - | - | - | $1,020,453 | 123 | $8,158,011 | Dec 17 | 20th Century Fox International | false |
| 2 | Valentine's Day | - | - | - | $578,600 | 60 | $593,982 | Feb 11 | Warner Bros. | false |
| 3 | The Wolfman | - | - | - | $467,129 | 86 | $596,189 | Feb 18 | Universal Pictures International (UPI) | false |
| 4 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $425,312 | 62 | $463,083 | Feb 11 | 20th Century Fox International | false |
| 5 | Kandagar | - | - | - | $406,679 | 56 | $406,679 | Feb 4 | - | false |
| 6 | Leap Year | - | - | - | $323,630 | 53 | $332,753 | Feb 4 | Universal Pictures International (UPI) | false |
| 7 | Nasha Russia. Yaytsa sudby | - | - | - | $262,662 | 81 | $1,466,269 | Jan 21 | - | false |
| 8 | Did You Hear About the Morgans? | - | - | - | $261,993 | 32 | $282,378 | Feb 11 | Sony Pictures Releasing | false |
| 9 | When in Rome | - | - | - | $232,729 | 63 | $469,206 | Feb 25 | Walt Disney Pictures | false |
| 10 | Shutter Island | - | - | - | $166,442 | 20 | $274,559 | Feb 18 | - | false |
| 11 | Dorian Gray | - | - | - | $144,125 | 21 | $144,125 | Feb 4 | - | false |
| 12 | The Imaginarium of Doctor Parnassus | - | - | - | $139,689 | 24 | $142,045 | Feb 4 | - | false |
| 13 | Up in the Air | - | - | - | $113,971 | 45 | $245,426 | Jan 28 | Paramount Pictures International | false |
| 14 | It's Complicated | - | - | - | $96,121 | 53 | $440,170 | Jan 21 | Universal Pictures International (UPI) | false |
| 15 | From Paris with Love | - | - | - | $82,610 | 21 | $82,610 | Feb 4 | - | false |
| 16 | The Lovely Bones | - | - | - | $58,858 | 42 | $124,833 | Feb 25 | Paramount Pictures International | false |
| 17 | Sherlock Holmes | - | - | - | $52,617 | 79 | $1,208,297 | Jan 14 | Warner Bros. | false |
| 18 | The Spy Next Door 2010 Re-release | - | - | - | $45,877 | 12 | $45,877 | Feb 18 | - | false |
| 19 | A Christmas Carol | - | - | - | $42,773 | 78 | $1,329,285 | Dec 31 | Walt Disney Pictures | false |
| 20 | Dear John | - | - | - | $29,510 | 13 | $69,096 | Feb 25 | - | false |
| 21 | The Princess and the Frog | - | - | - | $20,771 | 72 | $668,445 | Jan 7 | Walt Disney Pictures | false |
| 22 | Tooth Fairy | - | - | - | $15,103 | 13 | $38,395 | Jan 28 | - | false |
| 23 | Toy Story 2 2009 Re-release | - | - | - | $9,198 | 19 | $30,855 | Jan 21 | Walt Disney Pictures | false |
| 24 | Solomon Kane | - | - | - | $7,650 | 24 | $108,322 | Jan 14 | - | false |
| 25 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $6,778 | 66 | $383,816 | Dec 24 | 20th Century Fox International | false |
| 26 | Black Lightning | - | - | - | $5,118 | 90 | $959,440 | Dec 31 | Universal Pictures International (UPI) | false |
| 27 | Katyn | - | - | - | $1,686 | 10 | $1,686 | Feb 18 | - | false |
| 28 | Old Dogs | - | - | - | $878 | 47 | $425,053 | Dec 10 | Walt Disney Pictures | false |
