| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $406,666 | 13 | $576,300 | Jan 28 | 20th Century Fox International | false |
| 2 | Avatar | - | - | - | $308,232 | 18 | $1,917,323 | Dec 17 | 20th Century Fox International | false |
| 3 | Valentine's Day | - | - | - | $143,460 | 9 | $246,792 | Feb 18 | Warner Bros. | false |
| 4 | Did You Hear About the Morgans? | - | - | - | $112,181 | 8 | $117,342 | Feb 4 | Sony Pictures Releasing | false |
| 5 | The Wolfman | - | - | - | $77,268 | 7 | $127,464 | Feb 18 | United International Pictures | false |
| 6 | The Princess and the Frog | - | - | - | $61,730 | 9 | $115,260 | Jan 21 | Walt Disney Pictures | false |
| 7 | Cloudy with a Chance of Meatballs | - | - | - | $48,942 | 13 | $73,067 | Feb 11 | Sony Pictures Releasing | false |
| 8 | Sherlock Holmes | - | - | - | $46,400 | 9 | $261,903 | Jan 7 | Warner Bros. | false |
| 9 | The Men Who Stare at Goats | - | - | - | $45,853 | 4 | $74,580 | Jan 28 | - | false |
| 10 | Up in the Air | - | - | - | $40,390 | 5 | $125,379 | Jan 14 | United International Pictures | false |
| 11 | The Book of Eli | - | - | - | $36,934 | 6 | $90,552 | Jan 21 | - | false |
| 12 | Edge of Darkness | - | - | - | $22,932 | 4 | $27,536 | Feb 11 | - | false |
| 13 | The Other Man | - | - | - | $19,289 | 6 | $23,191 | Feb 4 | - | false |
| 14 | It's Complicated | - | - | - | $16,163 | 8 | $299,517 | Dec 24 | United International Pictures | false |
| 15 | Gamer | - | - | - | $15,873 | 6 | $19,952 | Feb 4 | - | false |
| 16 | Legion | - | - | - | $13,995 | 5 | $29,471 | Feb 25 | Sony Pictures Releasing | false |
| 17 | Invictus | - | - | - | $10,443 | 5 | $44,070 | Feb 25 | Warner Bros. | false |
| 18 | A Serious Man | - | - | - | $7,006 | 1 | $7,920 | Feb 4 | - | false |
| 19 | The Hurt Locker | - | - | - | $6,980 | 2 | $39,408 | Feb 18 | - | false |
| 20 | The Lovely Bones | - | - | - | $5,634 | 5 | $13,243 | Feb 25 | United International Pictures | false |
| 21 | An Education | - | - | - | $5,375 | 2 | $9,492 | Feb 18 | - | false |
| 22 | Planet 51 | - | - | - | $4,662 | 10 | $179,710 | Dec 31 | - | false |
