| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Avatar | - | - | - | $5,702,288 | 150 | $26,874,162 | Dec 17 | 20th Century Fox International | false |
| 2 | Valentine's Day | - | - | - | $2,669,226 | 106 | $3,320,832 | Feb 11 | Warner Bros. | false |
| 3 | The Princess and the Frog | - | - | - | $2,452,151 | 137 | $3,057,126 | Feb 4 | Walt Disney Pictures | false |
| 4 | Cloudy with a Chance of Meatballs | - | - | - | $1,666,099 | 85 | $2,447,098 | Feb 17 | Sony Pictures Releasing | false |
| 5 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $1,628,793 | 96 | $1,923,665 | Feb 11 | Warner Bros. | false |
| 6 | Eep! 2010 Re-release | - | - | - | $1,099,932 | 90 | $1,713,357 | Feb 18 | Independent Films | false |
| 7 | Shutter Island | - | - | - | $1,087,452 | 52 | $2,632,442 | Feb 18 | Universal Pictures International (UPI) | false |
| 8 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $978,395 | 119 | $7,077,813 | Dec 21 | Warner Bros. | false |
| 9 | Gangsterboys | - | - | - | $902,340 | 39 | $1,441,099 | Feb 18 | Independent Films | false |
| 10 | Edge of Darkness | - | - | - | $783,474 | 78 | $1,140,932 | Jan 28 | Entertainment One | false |
| 11 | Sherlock Holmes | - | - | - | $700,213 | 99 | $3,994,559 | Jan 7 | Warner Bros. | false |
| 12 | The Wolfman | - | - | - | $638,309 | 56 | $713,685 | Feb 11 | Universal Pictures International (UPI) | false |
| 13 | The Spy Next Door 2010 Re-release | - | - | - | $529,173 | 44 | $531,321 | Feb 4 | A-Film Distribution | false |
| 14 | Love Life | - | - | - | $473,969 | 125 | $12,514,413 | Nov 26 | Benelux Film Distributors | false |
| 15 | A Single Man | - | - | - | $468,832 | 20 | $891,594 | Feb 4 | Cinéart | false |
| 16 | The Girl Who Played with Fire | - | - | - | $465,099 | 58 | $1,072,278 | Jan 21 | Benelux Film Distributors | false |
| 17 | Did You Hear About the Morgans? | - | - | - | $350,374 | 47 | $1,088,087 | Jan 21 | Sony Pictures Releasing | false |
| 18 | A Prophet | - | - | - | $342,647 | 26 | $463,100 | Feb 4 | Cinemien | false |
| 19 | The Lovely Bones | - | - | - | $319,188 | 54 | $760,157 | Feb 25 | Universal Pictures International (UPI) | false |
| 20 | It's Complicated | - | - | - | $271,975 | 95 | $3,247,030 | Dec 24 | Universal Pictures International (UPI) | false |
| 21 | Anubis en de wraak van Arghus | - | - | - | $248,437 | 115 | $3,779,210 | Dec 17 | Independent Films | false |
| 22 | A Serious Man | - | - | - | $239,428 | 22 | $524,566 | Jan 21 | Universal Pictures International (UPI) | false |
| 23 | Up in the Air | - | - | - | $219,346 | 36 | $1,074,328 | Jan 14 | Universal Pictures International (UPI) | false |
| 24 | The Box | - | - | - | $203,872 | 44 | $238,452 | Feb 4 | Benelux Film Distributors | false |
| 25 | The Imaginarium of Doctor Parnassus | - | - | - | $160,776 | 20 | $184,903 | Feb 4 | Entertainment One | false |
| 26 | My Name Is Khan | - | - | - | $127,875 | 5 | $127,875 | Feb 11 | Warner Bros. | false |
| 27 | Nine | - | - | - | $78,022 | 39 | $110,258 | Feb 18 | Paradiso Entertainment | false |
| 28 | The Hell of '63 | - | - | - | $63,942 | 86 | $2,651,361 | Dec 17 | Entertainment One | false |
| 29 | Daybreakers | - | - | - | $50,063 | 16 | $79,304 | Feb 25 | Benelux Film Distributors | false |
| 30 | Where the Wild Things Are | - | - | - | $38,798 | 25 | $309,012 | Jan 14 | Warner Bros. | false |
| 31 | The Lawyers - A German Story | - | - | - | $23,418 | 18 | $797,529 | Nov 19 | Cinéart | false |
