| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Wolfman | - | - | - | $8,866,338 | 698 | $11,144,027 | Feb 12 | Universal Pictures International (UPI) | false |
| 2 | Avatar | - | - | - | $5,426,872 | 1,138 | $43,763,643 | Dec 17 | 20th Century Fox International | false |
| 3 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $4,747,967 | 700 | $6,024,219 | Feb 12 | 20th Century Fox International | false |
| 4 | Valentine's Day | - | - | - | $2,720,683 | 350 | $3,278,718 | Feb 12 | Warner Bros. | false |
| 5 | The Book of Eli | - | - | - | $2,315,202 | 300 | $4,043,777 | Jan 29 | Sony Pictures Releasing | false |
| 6 | It's Complicated | - | - | - | $2,270,791 | 350 | $3,497,634 | Jan 29 | Universal Pictures International (UPI) | false |
| 7 | Tooth Fairy | - | - | - | $2,115,707 | 500 | $7,890,387 | Jan 15 | 20th Century Fox International | false |
| 8 | The Lovely Bones | - | - | - | $1,555,161 | 352 | $2,898,173 | Feb 19 | Paramount Pictures International | false |
| 9 | Edge of Darkness | - | - | - | $954,838 | 354 | $4,070,888 | Feb 26 | Warner Bros. | false |
| 10 | The Fourth Kind | - | - | - | $945,800 | 225 | $2,577,037 | Jan 22 | Gussi Films | false |
| 11 | Invictus | - | - | - | $929,755 | 201 | $2,238,624 | Jan 22 | Warner Bros. | false |
| 12 | Up in the Air | - | - | - | $755,716 | 251 | $2,176,272 | Jan 22 | Paramount Pictures International | false |
| 13 | Did You Hear About the Morgans? | - | - | - | $579,547 | 216 | $1,739,167 | Jan 15 | Sony Pictures Releasing | false |
| 14 | Sherlock Holmes | - | - | - | $557,554 | 683 | $11,402,799 | Jan 1 | Warner Bros. | false |
| 15 | Daybreakers | - | - | - | $547,306 | 230 | $1,041,994 | Feb 19 | Gussi Films | false |
| 16 | Law Abiding Citizen | - | - | - | $536,674 | 252 | $2,163,319 | Jan 8 | - | false |
| 17 | When in Rome | - | - | - | $531,910 | 203 | $647,611 | Feb 5 | Walt Disney Pictures | false |
| 18 | Regresa | - | - | - | $528,287 | 230 | $1,396,505 | Jan 22 | - | false |
| 19 | The Hurt Locker | - | - | - | $385,295 | 67 | $1,114,807 | Feb 12 | Gussi Films | false |
| 20 | Astro Boy | - | - | - | $328,494 | 149 | $710,349 | Jan 29 | - | false |
| 21 | Bad Lieutenant: Port of Call New Orleans | - | - | - | $314,941 | 102 | $571,409 | Feb 5 | Gussi Films | false |
| 22 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $306,969 | 768 | $10,208,074 | Dec 25 | 20th Century Fox International | false |
| 23 | Zombieland | - | - | - | $291,912 | 200 | $1,250,209 | Jan 8 | Sony Pictures Releasing | false |
| 24 | Paranormal Activity | - | - | - | $276,997 | 362 | $5,940,056 | Dec 25 | Gussi Films | false |
| 25 | Messengers 2: The Scarecrow | - | - | - | $245,306 | 199 | $1,128,303 | Feb 26 | Videocine | false |
| 26 | Armored | - | - | - | $234,512 | 80 | $791,603 | Feb 5 | Sony Pictures Releasing | false |
| 27 | Love Happens | - | - | - | $222,629 | 180 | $786,953 | Feb 26 | - | false |
| 28 | Battle for Terra | - | - | - | $213,247 | 52 | $241,313 | Feb 19 | Gussi Films | false |
| 29 | All About Steve | - | - | - | $170,172 | 153 | $998,786 | Jan 1 | 20th Century Fox International | false |
| 30 | AAA, la película: Sin límite en el tiempo | - | - | - | $168,160 | 226 | $557,931 | Jan 22 | Videocine | false |
| 31 | Mongol: The Rise of Genghis Khan | - | - | - | $157,349 | 35 | $294,573 | Feb 5 | - | false |
| 32 | Franklyn | - | - | - | $156,390 | 100 | $234,744 | Feb 5 | - | false |
| 33 | Ninja Assassin | - | - | - | $154,642 | 120 | $430,480 | Jan 15 | Warner Bros. | false |
| 34 | Nine | - | - | - | $136,738 | 40 | $591,879 | Feb 26 | Sony Pictures Releasing | false |
| 35 | Mujer alabastrina | - | - | - | $123,475 | 108 | $135,251 | Feb 19 | - | false |
| 36 | An Education | - | - | - | $100,627 | 15 | $274,549 | Feb 19 | Sony Pictures Releasing | false |
| 37 | Labor Pains | - | - | - | $98,553 | 182 | $670,871 | Jan 8 | - | false |
| 38 | Pandorum | - | - | - | $94,254 | 100 | $285,967 | Jan 15 | Gussi Films | false |
| 39 | Everybody's Fine | - | - | - | $92,886 | 150 | $1,424,925 | Dec 25 | Walt Disney Pictures | false |
| 40 | Mutant Chronicles | - | - | - | $87,871 | 130 | $405,465 | Jan 8 | Videocine | false |
| 41 | Departures | - | - | - | $83,804 | 20 | $159,238 | Jan 29 | - | false |
| 42 | A Serious Man | - | - | - | $75,926 | 15 | $137,186 | Jan 29 | Universal Pictures International (UPI) | false |
| 43 | Paintball | - | - | - | $69,281 | 80 | $69,281 | Feb 5 | - | false |
| 44 | Motherhood | - | - | - | $52,718 | 40 | $188,480 | Jan 29 | Gussi Films | false |
| 45 | Julie & Julia | - | - | - | $39,809 | 40 | $594,723 | Oct 23 | Sony Pictures Releasing | false |
| 46 | Crazy Heart | - | - | - | $38,260 | 28 | $181,973 | Feb 26 | 20th Century Fox International | false |
| 47 | Nikté | - | - | - | $28,920 | 413 | $1,329,775 | Dec 17 | Universal Pictures International (UPI) | false |
| 48 | The Stepfather | - | - | - | $28,457 | 150 | $586,506 | Dec 11 | Sony Pictures Releasing | false |
| 49 | Fame | - | - | - | $28,177 | 151 | $275,939 | Jan 15 | - | false |
| 50 | What My Eyes Have Seen 2010 Re-release | - | - | - | $21,336 | 10 | $25,048 | Feb 19 | - | false |
| 51 | New York, I Love You | - | - | - | $19,612 | 39 | $362,806 | Dec 17 | - | false |
| 52 | Opium: Diary of a Madwoman | - | - | - | $15,987 | 9 | $59,534 | Jan 8 | - | false |
| 53 | The Milk of Sorrow | - | - | - | $14,399 | 10 | $52,630 | Jan 15 | - | false |
| 54 | Easy Virtue | - | - | - | $12,812 | 10 | $87,402 | Dec 4 | Sony Pictures Releasing | false |
| 55 | The Baader Meinhof Complex | - | - | - | $7,150 | 2 | $17,040 | Feb 12 | - | false |
| 56 | Lemon Tree | - | - | - | $1,348 | 11 | $52,284 | Dec 25 | - | false |
