| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Avatar | - | - | - | $434,746 | 12 | $1,690,463 | Dec 17 | 20th Century Fox International | false |
| 2 | Valentine's Day | - | - | - | $184,105 | 7 | $219,726 | Feb 11 | Warner Bros. | false |
| 3 | The Book of Eli | - | - | - | $103,781 | 6 | $204,507 | Jan 21 | Jaguar Film International Distribution | false |
| 4 | From Paris with Love | - | - | - | $88,181 | 7 | $179,264 | Feb 18 | Italian International Film | false |
| 5 | Edge of Darkness | - | - | - | $87,609 | 4 | $112,285 | Feb 4 | - | false |
| 6 | Did You Hear About the Morgans? | - | - | - | $77,190 | 6 | $111,947 | Jan 28 | Sony Pictures Releasing | false |
| 7 | The Wolfman | - | - | - | $73,941 | 7 | $115,714 | Feb 18 | United International Pictures | false |
| 8 | It's Complicated | - | - | - | $69,789 | 7 | $225,288 | Jan 14 | United International Pictures | false |
| 9 | Nine | - | - | - | $41,972 | 6 | $143,497 | Jan 14 | Italian International Film | false |
| 10 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $38,539 | 7 | $84,323 | Feb 25 | 20th Century Fox International | false |
| 11 | Everybody's Fine | - | - | - | $34,914 | 5 | $55,409 | Jan 28 | Walt Disney Pictures | false |
| 12 | Up in the Air | - | - | - | $25,919 | 6 | $85,880 | Jan 21 | United International Pictures | false |
| 13 | When in Rome | - | - | - | $23,293 | 7 | $121,320 | Feb 25 | Walt Disney Pictures | false |
| 14 | The Lovely Bones | - | - | - | $13,545 | 6 | $13,545 | Feb 25 | United International Pictures | false |
| 15 | Agora | - | - | - | $8,620 | 6 | $134,053 | Dec 31 | Italian International Film | false |
| 16 | New York, I Love You 2010 Re-release | - | - | - | $8,164 | 3 | $8,164 | Feb 4 | - | false |
| 17 | The Men Who Stare at Goats | - | - | - | $7,824 | 3 | $7,824 | Feb 25 | - | false |
| 18 | Law Abiding Citizen | - | - | - | $7,107 | 4 | $39,066 | Jan 14 | - | false |
| 19 | Bad Lieutenant: Port of Call New Orleans | - | - | - | $7,104 | 3 | $7,104 | Feb 11 | - | false |
| 20 | Paranormal Activity | - | - | - | $5,532 | 4 | $12,504 | Jan 28 | - | false |
| 21 | Sherlock Holmes | - | - | - | $5,234 | 7 | $304,315 | Dec 24 | Warner Bros. | false |
| 22 | Ponyo | - | - | - | $3,360 | 4 | $3,360 | Feb 4 | - | false |
| 23 | Siraj El Wadi | - | - | - | $3,120 | 5 | $75,485 | Nov 5 | Italian International Film | false |
| 24 | The Princess and the Frog | - | - | - | $2,463 | 7 | $143,624 | Dec 10 | Walt Disney Pictures | false |
| 25 | The Time That Remains | - | - | - | $2,252 | 1 | $13,129 | Jan 21 | Prime Pictures | false |
| 26 | Escaping Tel Aviv | - | - | - | $2,189 | 3 | $38,125 | Dec 24 | - | false |
| 27 | Old Dogs | - | - | - | $2,103 | 7 | $172,031 | Nov 26 | Walt Disney Pictures | false |
| 28 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $1,933 | 3 | $92,395 | Dec 24 | 20th Century Fox International | false |
| 29 | A Christmas Carol | - | - | - | $1,284 | 8 | $394,689 | Nov 19 | Walt Disney Pictures | false |
| 30 | Love Happens | - | - | - | $989 | 6 | $83,235 | Nov 19 | Italian International Film | false |
| 31 | Sunshine Cleaning | - | - | - | $742 | 3 | $742 | Feb 4 | - | false |
| 32 | Case 39 | - | - | - | $661 | 6 | $84,008 | Dec 10 | United International Pictures | false |
| 33 | To Love a Woman | - | - | - | $605 | 2 | $2,674 | Jan 28 | Italian International Film | false |
| 34 | The Box | - | - | - | $459 | 7 | $57,651 | Dec 24 | Italian International Film | false |
| 35 | Planet 51 | - | - | - | $297 | 6 | $30,874 | Dec 24 | - | false |
| 36 | Little Nicholas | - | - | - | $206 | 4 | $90,497 | Dec 3 | Joseph Chacra & Sons | false |
