| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Avatar | - | - | - | $329,604 | 21 | $2,029,219 | Dec 17 | 20th Century Fox International | false |
| 2 | Valentine's Day | - | - | - | $140,793 | 10 | $155,753 | Feb 11 | Warner Bros. | false |
| 3 | It's Complicated | - | - | - | $128,520 | 7 | $179,181 | Jan 28 | United International Pictures | false |
| 4 | Up in the Air | - | - | - | $119,794 | 7 | $139,985 | Feb 4 | United International Pictures | false |
| 5 | Cloudy with a Chance of Meatballs | - | - | - | $101,531 | 16 | $151,058 | Feb 4 | Sony Pictures Releasing | false |
| 6 | The Book of Eli | - | - | - | $96,107 | 9 | $219,043 | Jan 21 | - | false |
| 7 | The Wolfman | - | - | - | $94,027 | 9 | $145,585 | Feb 18 | United International Pictures | false |
| 8 | The Princess and the Frog | - | - | - | $73,415 | 11 | $158,092 | Jan 21 | Walt Disney Pictures | false |
| 9 | Dear John | - | - | - | $62,705 | 6 | $99,856 | Feb 18 | - | false |
| 10 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $59,069 | 8 | $83,991 | Feb 11 | 20th Century Fox International | false |
| 11 | Paranormal Activity | - | - | - | $46,445 | 5 | $70,475 | Jan 28 | - | false |
| 12 | Sherlock Holmes | - | - | - | $37,597 | 10 | $419,040 | Dec 24 | Warner Bros. | false |
| 13 | An Education | - | - | - | $26,276 | 4 | $45,713 | Jan 21 | - | false |
| 14 | Arthur and the Revenge of Maltazard | - | - | - | $25,104 | 13 | $266,662 | Dec 31 | - | false |
| 15 | Edge of Darkness | - | - | - | $21,324 | 5 | $47,334 | Feb 25 | - | false |
| 16 | Did You Hear About the Morgans? | - | - | - | $20,772 | 12 | $129,047 | Jan 14 | Sony Pictures Releasing | false |
| 17 | The Lovely Bones | - | - | - | $17,945 | 7 | $58,794 | Feb 25 | United International Pictures | false |
| 18 | The Spy Next Door 2010 Re-release | - | - | - | $17,945 | 5 | $74,826 | Feb 25 | - | false |
| 19 | The Rebound | - | - | - | $16,520 | 7 | $180,949 | Dec 31 | - | false |
| 20 | Moon | - | - | - | $14,595 | 2 | $18,476 | Jan 28 | - | false |
| 21 | The Fourth Kind | - | - | - | $11,648 | 5 | $104,760 | Dec 31 | - | false |
| 22 | The Men Who Stare at Goats | - | - | - | $11,149 | 4 | $90,474 | Jan 7 | - | false |
| 23 | Everybody's Fine | - | - | - | $7,795 | 1 | $7,795 | Feb 11 | Walt Disney Pictures | false |
| 24 | Nine | - | - | - | $4,464 | 5 | $47,618 | Jan 14 | - | false |
| 25 | Hachi: A Dog's Tale | - | - | - | $3,606 | 1 | $5,413 | Feb 18 | - | false |
| 26 | Nothing But the Truth | - | - | - | $3,454 | 4 | $36,190 | Jan 7 | - | false |
