| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Avatar | - | - | - | $29,765,950 | 738 | $156,632,531 | Dec 17 | 20th Century Fox International | false |
| 2 | Sherlock Holmes | - | - | - | $10,690,759 | 651 | $16,629,510 | Jan 28 | Warner Bros. | false |
| 3 | Valentine's Day | - | - | - | $6,865,573 | 435 | $8,296,049 | Feb 11 | Warner Bros. | false |
| 4 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $6,439,075 | 657 | $7,968,745 | Feb 11 | 20th Century Fox International | false |
| 5 | Cloudy with a Chance of Meatballs | - | - | - | $5,902,228 | 583 | $8,962,447 | Jan 28 | Sony Pictures Releasing | false |
| 6 | Up in the Air | - | - | - | $5,772,717 | 266 | $7,665,802 | Feb 4 | Paramount Pictures International | false |
| 7 | Time You Change | - | - | - | $4,955,920 | 435 | $4,955,920 | Feb 4 | Constantin Film | false |
| 8 | It's Complicated | - | - | - | $4,161,982 | 558 | $9,831,613 | Jan 21 | Universal Pictures International (UPI) | false |
| 9 | Friendship! 2010 Re-release | - | - | - | $3,880,167 | 435 | $14,637,870 | Jan 14 | Sony Pictures Releasing | false |
| 10 | Shutter Island | - | - | - | $3,799,817 | 481 | $14,708,736 | Feb 25 | Concorde Filmverleih | false |
| 11 | The Girl Who Played with Fire | - | - | - | $3,230,450 | 178 | $4,526,144 | Feb 4 | - | false |
| 12 | The Wolfman | - | - | - | $2,945,091 | 509 | $3,053,121 | Feb 11 | Universal Pictures International (UPI) | false |
| 13 | Recep Ivedik 3 | - | - | - | $2,792,224 | 79 | $2,825,842 | Feb 11 | - | false |
| 14 | The Book of Eli | - | - | - | $2,620,064 | 305 | $3,543,027 | Feb 18 | TOBIS Film | false |
| 15 | The Crocodiles Strike Back | - | - | - | $2,238,448 | 471 | $4,719,996 | Jan 21 | Constantin Film | false |
| 16 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $1,948,532 | 625 | $15,512,720 | Dec 24 | 20th Century Fox International | false |
| 17 | Rock It! | - | - | - | $1,939,825 | 370 | $3,571,286 | Feb 18 | Walt Disney Pictures | false |
| 18 | The Ghost Writer | - | - | - | $1,775,919 | 270 | $3,147,954 | Feb 18 | Kinowelt Filmverleih | false |
| 19 | The Lovely Bones | - | - | - | $1,693,050 | 318 | $2,316,186 | Feb 18 | Paramount Pictures International | false |
| 20 | The Hairdresser | - | - | - | $1,413,537 | 134 | $4,805,519 | Feb 18 | Constantin Film | false |
| 21 | Soul Kitchen | - | - | - | $1,135,072 | 240 | $10,813,421 | Dec 24 | - | false |
| 22 | The Last Station 2010 Re-release | - | - | - | $1,097,360 | 127 | $1,728,741 | Jan 28 | Warner Bros. | false |
| 23 | Julia's Disappearance | - | - | - | $1,083,071 | 74 | $1,680,636 | Feb 4 | X Verleih AG | false |
| 24 | Oceans | - | - | - | $951,762 | 278 | $4,516,253 | Feb 25 | Universum Film (UFA) | false |
| 25 | A Serious Man | - | - | - | $875,885 | 61 | $1,812,097 | Jan 21 | - | false |
| 26 | Invictus | - | - | - | $544,471 | 120 | $763,812 | Feb 18 | Warner Bros. | false |
| 27 | Same Same But Different | - | - | - | $516,276 | 117 | $1,174,322 | Jan 21 | Delphi Filmverleih Produktion | false |
| 28 | The White Ribbon | - | - | - | $495,664 | 120 | $5,601,024 | Oct 15 | X Verleih AG | false |
| 29 | The Princess and the Frog | - | - | - | $466,774 | 542 | $11,780,091 | Dec 10 | Walt Disney Pictures | false |
| 30 | The Imaginarium of Doctor Parnassus | - | - | - | $390,317 | 276 | $4,863,307 | Jan 7 | Concorde Filmverleih | false |
| 31 | Nanga Parbat | - | - | - | $379,088 | 230 | $2,027,540 | Jan 14 | Senator Film | false |
| 32 | Did You Hear About the Morgans? | - | - | - | $325,880 | 502 | $6,186,992 | Jan 7 | Sony Pictures Releasing | false |
| 33 | Surrogates | - | - | - | $303,304 | 248 | $1,984,038 | Jan 21 | Walt Disney Pictures | false |
| 34 | New York, I Love You 2010 Re-release | - | - | - | $296,511 | 77 | $472,583 | Jan 28 | Concorde Filmverleih | false |
| 35 | Albert Schweitzer | - | - | - | $169,370 | 169 | $1,766,178 | Dec 24 | - | false |
| 36 | An Education | - | - | - | $166,544 | 100 | $287,519 | Feb 18 | Sony Pictures Releasing | false |
| 37 | Nine | - | - | - | $156,903 | 153 | $293,875 | Feb 25 | Senator Film | false |
| 38 | De l'autre côté du lit | - | - | - | $144,464 | 94 | $215,135 | Jan 28 | Movienet | false |
| 39 | The Murder Farm | - | - | - | $118,137 | 128 | $1,688,518 | Nov 19 | Constantin Film | false |
| 40 | Queen to Play | - | - | - | $108,302 | 61 | $725,610 | Jan 7 | Concorde Filmverleih | false |
| 41 | Welcome | - | - | - | $106,203 | 35 | $131,355 | Feb 4 | Arsenal Filmverleih | false |
| 42 | Dragon Trap | - | - | - | $103,743 | 56 | $243,868 | Jan 28 | Maxximum Film und Kunst GmbH | false |
| 43 | Dinosaurier | - | - | - | $95,249 | 297 | $2,288,787 | Dec 24 | Constantin Film | false |
| 44 | Leaving | - | - | - | $90,016 | 43 | $150,044 | Jan 28 | Alamode Film | false |
| 45 | Pope Joan | - | - | - | $77,671 | 542 | $25,010,090 | Oct 22 | Constantin Film | false |
| 46 | Sacred Demijohn 2 | - | - | - | $64,439 | 34 | $414,581 | Jan 21 | - | false |
| 47 | 13 Semester | - | - | - | $57,137 | 153 | $1,436,375 | Jan 7 | 20th Century Fox International | false |
| 48 | Bad Lieutenant: Port of Call New Orleans | - | - | - | $54,389 | 35 | $54,389 | Feb 25 | - | false |
| 49 | Armored | - | - | - | $53,726 | 100 | $122,892 | Feb 4 | Sony Pictures Releasing | false |
| 50 | Beyond a Reasonable Doubt | - | - | - | $44,670 | 102 | $151,178 | Feb 4 | - | false |
| 51 | Where the Wild Things Are | - | - | - | $43,981 | 214 | $1,110,733 | Dec 17 | Warner Bros. | false |
| 52 | Plastic Planet | - | - | - | $41,392 | 36 | $113,311 | Feb 25 | - | false |
| 53 | Planet 51 | - | - | - | $37,874 | 324 | $2,181,772 | Dec 3 | Sony Pictures Releasing | false |
