| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Avatar | - | - | - | $7,451,887 | 656 | $57,778,619 | Dec 18 | 20th Century Fox International | false |
| 2 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $5,406,769 | 302 | $9,290,334 | Feb 12 | 20th Century Fox International | false |
| 3 | The Final Destination | - | - | - | $3,221,830 | 246 | $4,547,387 | Feb 5 | PlayArte Pictures | false |
| 4 | The Wolfman | - | - | - | $3,057,967 | 289 | $4,250,237 | Feb 12 | Universal Pictures International (UPI) | false |
| 5 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $2,354,514 | 414 | $21,977,969 | Jan 8 | 20th Century Fox International | false |
| 6 | Valentine's Day | - | - | - | $2,045,228 | 160 | $4,405,954 | Feb 19 | Warner Bros. | false |
| 7 | Up in the Air | - | - | - | $1,856,042 | 167 | $4,427,613 | Jan 22 | Paramount Pictures International | false |
| 8 | Tooth Fairy | - | - | - | $1,731,149 | 177 | $5,197,136 | Jan 22 | 20th Century Fox International | false |
| 9 | Sherlock Holmes | - | - | - | $1,587,646 | 342 | $12,224,946 | Jan 8 | Warner Bros. | false |
| 10 | Edge of Darkness | - | - | - | $1,489,785 | 155 | $2,274,542 | Jan 29 | - | false |
| 11 | Invictus | - | - | - | $1,273,982 | 82 | $1,923,500 | Jan 29 | Warner Bros. | false |
| 12 | The Lovely Bones | - | - | - | $1,121,360 | 175 | $1,612,729 | Feb 19 | Paramount Pictures International | false |
| 13 | High School Musical: O Desafio | - | - | - | $893,712 | 203 | $1,149,290 | Feb 5 | Walt Disney Pictures | false |
| 14 | It's Complicated | - | - | - | $884,459 | 178 | $4,694,495 | Feb 26 | Universal Pictures International (UPI) | false |
| 15 | Precious | - | - | - | $538,094 | 71 | $927,316 | Feb 12 | PlayArte Pictures | false |
| 16 | Toy Story 2009 Re-release | - | - | - | $537,719 | 101 | $730,147 | Feb 26 | Walt Disney Pictures | false |
| 17 | The Hurt Locker | - | - | - | $326,649 | 62 | $820,754 | Feb 5 | - | false |
| 18 | Nine | - | - | - | $274,237 | 40 | $498,938 | Jan 29 | Sony Pictures Releasing | false |
| 19 | The White Ribbon | - | - | - | $268,001 | 26 | $343,187 | Feb 12 | - | false |
| 20 | Zombieland | - | - | - | $199,706 | 47 | $408,565 | Jan 29 | Sony Pictures Releasing | false |
| 21 | Xuxa and the Mystery of the Little Ugly Princess | - | - | - | $192,820 | 227 | $4,718,615 | Dec 25 | PlayArte Pictures | false |
| 22 | Astro Boy | - | - | - | $157,951 | 76 | $490,745 | Jan 22 | Paris Filmes | false |
| 23 | An Education | - | - | - | $138,925 | 13 | $337,832 | Feb 19 | Sony Pictures Releasing | false |
| 24 | Ninja Assassin | - | - | - | $130,142 | 45 | $170,870 | Feb 5 | Warner Bros. | false |
| 25 | Pandorum | - | - | - | $76,202 | 36 | $155,391 | Feb 26 | - | false |
| 26 | Where the Wild Things Are | - | - | - | $73,822 | 24 | $447,021 | Jan 15 | Warner Bros. | false |
| 27 | The Messenger | - | - | - | $68,307 | 20 | $95,961 | Feb 19 | Paris Filmes | false |
| 28 | Julie & Julia | - | - | - | $64,887 | 53 | $1,261,620 | Nov 27 | Sony Pictures Releasing | false |
| 29 | The Fourth Kind | - | - | - | $54,852 | 65 | $896,656 | Jan 1 | - | false |
| 30 | Easy Virtue | - | - | - | $21,856 | 6 | $201,042 | Oct 23 | Sony Pictures Releasing | false |
| 31 | 2012 | - | - | - | $21,837 | 550 | $25,652,732 | Nov 13 | Sony Pictures Releasing | false |
| 32 | Management | - | - | - | $20,420 | 19 | $483,303 | Dec 11 | - | false |
| 33 | Chéri | - | - | - | $17,884 | 28 | $188,916 | Jan 22 | - | false |
| 34 | Bad Lieutenant: Port of Call New Orleans | - | - | - | $17,223 | 72 | $624,423 | Jan 15 | - | false |
| 35 | The Assailant | - | - | - | $1,038 | 145 | $2,019,443 | Oct 30 | Walt Disney Pictures | false |
| 36 | Up | - | - | - | $16 | 329 | $10,528,510 | Sep 4 | Walt Disney Pictures | false |
