| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Avatar | - | - | - | $4,040,229 | 148 | $13,778,096 | Jan 1 | 20th Century Fox International | false |
| 2 | Sherlock Holmes | - | - | - | $883,193 | 97 | $2,701,752 | Jan 14 | Warner Bros. | false |
| 3 | Old Dogs | - | - | - | $852,335 | 68 | $1,506,322 | Jan 21 | Walt Disney Pictures | false |
| 4 | The Wolfman | - | - | - | $796,836 | 67 | $1,121,565 | Feb 11 | Universal Pictures International (UPI) | false |
| 5 | Valentine's Day | - | - | - | $758,551 | 67 | $885,179 | Feb 11 | Warner Bros. | false |
| 6 | Toy Story 2009 Re-release | - | - | - | $620,584 | 30 | $620,584 | Feb 4 | Walt Disney Pictures | false |
| 7 | Invictus | - | - | - | $614,439 | 52 | $981,517 | Jan 28 | Warner Bros. | false |
| 8 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $567,362 | 98 | $1,090,189 | Jan 21 | 20th Century Fox International | false |
| 9 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $499,223 | 65 | $724,087 | Feb 18 | 20th Century Fox International | false |
| 10 | Tooth Fairy | - | - | - | $457,900 | 54 | $482,136 | Feb 4 | 20th Century Fox International | false |
| 11 | Toy Story 2 2009 Re-release | - | - | - | $418,777 | 30 | $418,777 | Feb 18 | Walt Disney Pictures | false |
| 12 | The Hurt Locker | - | - | - | $395,945 | 51 | $791,443 | Feb 4 | Distribution Company | false |
| 13 | The Princess and the Frog | - | - | - | $336,681 | 103 | $1,922,032 | Jan 7 | Walt Disney Pictures | false |
| 14 | Up in the Air | - | - | - | $295,079 | 50 | $722,249 | Jan 21 | Paramount Pictures International | false |
| 15 | Edge of Darkness | - | - | - | $288,310 | 65 | $1,141,602 | Feb 25 | Warner Bros. | false |
| 16 | It's Complicated | - | - | - | $263,718 | 63 | $1,311,574 | Jan 7 | Universal Pictures International (UPI) | false |
| 17 | Precious | - | - | - | $182,857 | 31 | $303,251 | Feb 11 | - | false |
| 18 | Law Abiding Citizen | - | - | - | $175,439 | 42 | $179,980 | Feb 11 | Alfa Films | false |
| 19 | The Lovely Bones | - | - | - | $169,892 | 57 | $211,753 | Feb 18 | Paramount Pictures International | false |
| 20 | An Education | - | - | - | $169,372 | 15 | $186,751 | Feb 4 | Sony Pictures Releasing | false |
| 21 | The Girl with the Dragon Tattoo | - | - | - | $162,661 | 23 | $278,936 | Feb 18 | - | false |
| 22 | Birds of Paradise | - | - | - | $151,650 | 41 | $48,538 | Feb 18 | Sony Pictures Releasing | false |
| 23 | Nine | - | - | - | $151,262 | 25 | $268,101 | Jan 28 | Sony Pictures Releasing | false |
| 24 | Daybreakers | - | - | - | $148,679 | 37 | $388,845 | Jan 21 | Distribution Company | false |
| 25 | Astro Boy | - | - | - | $103,386 | 29 | $174,796 | Jan 28 | Alfa Films | false |
| 26 | The Imaginarium of Doctor Parnassus | - | - | - | $90,605 | 30 | $242,463 | Feb 25 | Sony Pictures Releasing | false |
| 27 | Zombieland | - | - | - | $56,871 | 20 | $107,716 | Jan 28 | Sony Pictures Releasing | false |
| 28 | A Serious Man | - | - | - | $53,690 | 15 | $149,243 | Feb 25 | Universal Pictures International (UPI) | false |
| 29 | 2012 | - | - | - | $42,908 | 142 | $4,040,705 | Dec 3 | Sony Pictures Releasing | false |
| 30 | The Young Victoria | - | - | - | $34,177 | 25 | $182,531 | Jan 14 | Distribution Company | false |
| 31 | Nora's Will | - | - | - | $30,993 | 11 | $53,724 | Jan 28 | Primer Plano Film Group | false |
| 32 | The Wedding Song | - | - | - | $22,418 | 6 | $35,005 | Feb 18 | Primer Plano Film Group | false |
| 33 | Ninja Assassin | - | - | - | $19,603 | 26 | $131,003 | Jan 7 | Warner Bros. | false |
| 34 | Easy Virtue | - | - | - | $10,877 | 14 | $106,464 | Jan 14 | Sony Pictures Releasing | false |
| 35 | Halloween II | - | - | - | $9,906 | 36 | $119,236 | Jan 7 | Distribution Company | false |
| 36 | Jellyfish 2010 Re-release | - | - | - | $9,543 | 5 | $24,761 | Jan 21 | - | false |
| 37 | Paranormal Activity | - | - | - | $4,239 | 62 | $1,272,176 | Dec 10 | Distribution Company | false |
| 38 | Andres Doesn't Want to Take a Nap | - | - | - | $4,235 | 6 | $14,512 | Feb 4 | Primer Plano Film Group | false |
| 39 | The Wind Journeys | - | - | - | $3,936 | 3 | $5,374 | Feb 11 | Primer Plano Film Group | false |
| 40 | Departures | - | - | - | $3,728 | 5 | $20,037 | Jan 14 | Alfa Films | false |
| 41 | Let the Right One In | - | - | - | $2,783 | 12 | $172,087 | Dec 3 | Pachamama Cine | false |
| 42 | Spread | - | - | - | $1,694 | 33 | $121,929 | Jan 1 | Impacto Cine | false |
| 43 | Le code a changé | - | - | - | $1,574 | 19 | $135,715 | Jan 1 | Alfa Films | false |
| 44 | Acne | - | - | - | $365 | 2 | $3,839 | Jan 7 | Primer Plano Film Group | false |
