| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Max Th | Opening | % of Total
| Open Th | Open | Close | Distributor
| Estimated
|
|---|
| 1 | The Curious Case of Benjamin Button | - | - | - | $15,750,900 | 502 | $3,871,237 | 24.6% | 477 | Feb 13 | - | Warner Bros. | false |
| 2 | Ex | - | - | - | $15,340,865 | 571 | $4,645,796 | 30.3% | 571 | Feb 6 | - | 01 Distribution | false |
| 3 | Confessions of a Shopaholic | - | - | - | $6,192,300 | 369 | $2,056,487 | 33.2% | 369 | Feb 27 | - | Walt Disney Pictures | false |
| 4 | Questo piccolo grande amore | - | - | - | $4,878,552 | 467 | $2,390,117 | 49% | 467 | Feb 11 | - | Medusa Distribuzione | false |
| 5 | The Reader | - | - | - | $3,645,596 | 161 | $689,170 | 18.9% | 161 | Feb 20 | - | 01 Distribution | false |
| 6 | Inkheart | - | - | - | $3,289,477 | 269 | $1,186,936 | 36.1% | 269 | Feb 20 | - | Eagle Pictures | false |
| 7 | Iago | - | - | - | $2,678,424 | 378 | $1,221,317 | 45.6% | 378 | Feb 27 | - | Medusa Distribuzione | false |
| 8 | The Unborn | - | - | - | $2,470,810 | 179 | $982,852 | 39.8% | 179 | Feb 27 | - | Universal Pictures International (UPI) | false |
| 9 | Bride Wars | - | - | - | $1,742,791 | 285 | $867,124 | 49.8% | 285 | Feb 20 | - | 20th Century Fox International | false |
| 10 | Friday the 13th | - | - | - | $1,613,528 | 198 | $830,400 | 51.5% | 198 | Feb 13 | - | Universal Pictures International (UPI) | false |
| 11 | Underworld: Rise of the Lycans | - | - | - | $1,592,463 | 119 | $623,409 | 39.1% | 119 | Feb 20 | - | Sony Pictures Releasing | false |
| 12 | Giulia Doesn't Date at Night | - | - | - | $1,118,316 | 179 | $435,740 | 39% | 179 | Feb 27 | - | 01 Distribution | false |
| 13 | Horsemen | - | - | - | $941,773 | 148 | $542,317 | 57.6% | 148 | Feb 6 | - | Moviemax | false |
| 14 | Frost/Nixon | - | - | - | $879,567 | 151 | $369,775 | 42% | 151 | Feb 6 | - | Universal Pictures International (UPI) | false |
| 15 | Space Chimps | - | - | - | $719,060 | 183 | $388,415 | 54% | 183 | Feb 6 | - | Medusa Distribuzione | false |
| 16 | The Wave | - | - | - | $696,752 | 57 | $122,314 | 17.6% | 57 | Feb 27 | - | BIM Distribuzione | false |
| 17 | I've Loved You So Long | - | - | - | $554,704 | 54 | $145,611 | 26.3% | 47 | Feb 6 | - | Mikado Film | false |
| 18 | Impy's Wonderland | - | - | - | $273,774 | 143 | $150,000 | 54.8% | 143 | Feb 27 | - | Mediafilm | false |
| 19 | Eagle Eye | - | - | - | $205,233 | 51 | $136,980 | 66.7% | 51 | Feb 20 | - | Universal Pictures International (UPI) | false |
| 20 | The Sicilian Girl | - | - | - | $199,438 | 53 | $80,570 | 40.4% | 53 | Feb 27 | - | Istituto Luce | false |
| 21 | Religulous | - | - | - | $102,320 | 22 | $36,692 | 35.9% | 22 | Feb 13 | - | Eagle Pictures | false |
| 22 | Katyn | - | - | - | $99,729 | 11 | $10,032 | 10.1% | 8 | Feb 13 | - | - | false |
| 23 | Hotel for Dogs | - | - | - | $98,529 | 49 | $45,213 | 45.9% | 49 | Feb 20 | - | Universal Pictures International (UPI) | false |
| 24 | Waiting for the sun | - | - | - | $62,079 | 43 | $35,211 | 56.7% | 43 | Feb 20 | - | Mikado Film | false |
| 25 | In the Name of the King: A Dungeon Siege Tale | - | - | - | $34,923 | 13 | $3,677 | 10.5% | 3 | Feb 27 | - | One Movie | false |
| 26 | Nick and Norah's Infinite Playlist | - | - | - | $15,228 | 11 | $11,539 | 75.8% | 11 | Feb 13 | - | Sony Pictures Releasing | false |
| 27 | Le premier cri | - | - | - | $5,669 | 10 | $5,669 | 100% | 10 | Feb 13 | - | Lucky Red | false |
| 28 | Nient'altro che noi | - | - | - | $2,870 | 1 | - | - | - | Feb 6 | - | - | false |
| 29 | Maria Venera | - | - | - | $2,608 | 4 | $2,608 | 100% | 4 | Feb 20 | - | - | false |
| 30 | Puccini and the Girl | - | - | - | $2,334 | 1 | $2,334 | 100% | 1 | Feb 27 | - | - | false |
