| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Ex | - | - | - | $12,481,075 | 571 | $15,340,865 | Feb 6 | 01 Distribution | false |
| 2 | The Curious Case of Benjamin Button | - | - | - | $11,396,135 | 502 | $15,750,900 | Feb 13 | Warner Bros. | false |
| 3 | Italians | - | - | - | $4,155,099 | 611 | $17,026,331 | Jan 23 | Filmauro | false |
| 4 | Questo piccolo grande amore | - | - | - | $4,143,837 | 467 | $4,878,552 | Feb 11 | Medusa Distribuzione | false |
| 5 | Valkyrie | - | - | - | $3,612,345 | 394 | $6,094,571 | Jan 30 | 01 Distribution | false |
| 6 | Madagascar: Escape 2 Africa | - | - | - | $2,910,295 | 583 | $34,915,869 | Dec 19 | Universal Pictures International (UPI) | false |
| 7 | Revolutionary Road | - | - | - | $2,804,064 | 281 | $4,832,138 | Jan 30 | Universal Pictures International (UPI) | false |
| 8 | Inkheart | - | - | - | $2,368,185 | 269 | $3,289,477 | Feb 20 | Eagle Pictures | false |
| 9 | Journey to the Center of the Earth | - | - | - | $2,353,448 | 276 | $11,724,131 | Jan 16 | 01 Distribution | false |
| 10 | Seven Pounds | - | - | - | $2,274,804 | 553 | $16,157,223 | Jan 9 | Sony Pictures Releasing | false |
| 11 | Confessions of a Shopaholic | - | - | - | $2,056,487 | 369 | $6,192,300 | Feb 27 | Walt Disney Pictures | false |
| 12 | The Reader | - | - | - | $1,696,134 | 161 | $3,645,596 | Feb 20 | 01 Distribution | false |
| 13 | Slumdog Millionaire | - | - | - | $1,676,156 | 160 | $9,341,549 | Dec 5 | Lucky Red | false |
| 14 | Doubt | - | - | - | $1,569,087 | 155 | $2,302,842 | Jan 30 | Walt Disney Pictures | false |
| 15 | Friday the 13th | - | - | - | $1,559,704 | 198 | $1,613,528 | Feb 13 | Universal Pictures International (UPI) | false |
| 16 | Bride Wars | - | - | - | $1,510,568 | 285 | $1,742,791 | Feb 20 | 20th Century Fox International | false |
| 17 | Iago | - | - | - | $1,221,317 | 378 | $2,678,424 | Feb 27 | Medusa Distribuzione | false |
| 18 | Underworld: Rise of the Lycans | - | - | - | $1,218,845 | 119 | $1,592,463 | Feb 20 | Sony Pictures Releasing | false |
| 19 | Milk | - | - | - | $1,148,638 | 174 | $3,202,523 | Jan 23 | BIM Distribuzione | false |
| 20 | The Unborn | - | - | - | $982,852 | 179 | $2,470,810 | Feb 27 | Universal Pictures International (UPI) | false |
| 21 | Horsemen | - | - | - | $941,773 | 148 | $941,773 | Feb 6 | Moviemax | false |
| 22 | Beverly Hills Chihuahua | - | - | - | $858,736 | 248 | $5,244,509 | Jan 16 | Walt Disney Pictures | false |
| 23 | Frost/Nixon | - | - | - | $806,772 | 151 | $879,567 | Feb 6 | Universal Pictures International (UPI) | false |
| 24 | Yes Man | - | - | - | $733,060 | 349 | $10,187,158 | Jan 9 | Warner Bros. | false |
| 25 | Space Chimps | - | - | - | $706,297 | 183 | $719,060 | Feb 6 | Medusa Distribuzione | false |
| 26 | Bolt | - | - | - | $683,379 | 467 | $7,073,495 | Nov 28 | Walt Disney Pictures | false |
| 27 | Australia | - | - | - | $642,714 | 485 | $7,351,155 | Jan 16 | 20th Century Fox International | false |
| 28 | I've Loved You So Long | - | - | - | $464,407 | 54 | $554,704 | Feb 6 | Mikado Film | false |
| 29 | Giulia Doesn't Date at Night | - | - | - | $435,740 | 179 | $1,118,316 | Feb 27 | 01 Distribution | false |
| 30 | Easy Virtue | - | - | - | $384,709 | 142 | $3,590,951 | Jan 9 | Eagle Pictures | false |
| 31 | Welcome to the Sticks | - | - | - | $302,368 | 325 | $4,245,593 | Oct 31 | Medusa Distribuzione | false |
| 32 | Waltz with Bashir | - | - | - | $219,492 | 44 | $1,041,913 | Jan 9 | Lucky Red | false |
| 33 | The Boy in the Striped Pajamas | - | - | - | $217,057 | 103 | $3,802,419 | Dec 19 | Walt Disney Pictures | false |
| 34 | Eagle Eye | - | - | - | $198,571 | 51 | $205,233 | Feb 20 | Universal Pictures International (UPI) | false |
| 35 | Empties | - | - | - | $171,976 | 23 | $428,775 | Jan 16 | Fandango | false |
| 36 | Impy's Wonderland | - | - | - | $150,000 | 143 | $273,774 | Feb 27 | Mediafilm | false |
| 37 | Defiance | - | - | - | $129,919 | 188 | $1,224,839 | Jan 23 | Medusa Distribuzione | false |
| 38 | Lemon Tree | - | - | - | $125,394 | 47 | $1,471,720 | Dec 12 | Teodora Film | false |
| 39 | The Wave | - | - | - | $122,314 | 57 | $696,752 | Feb 27 | BIM Distribuzione | false |
| 40 | Home | - | - | - | $118,307 | 17 | $159,990 | Jan 30 | Teodora Film | false |
| 41 | The Visitor | - | - | - | $96,277 | 57 | $2,194,531 | Dec 5 | Bolero Film | false |
| 42 | Religulous | - | - | - | $95,638 | 22 | $102,320 | Feb 13 | Eagle Pictures | false |
| 43 | Appaloosa | - | - | - | $88,077 | 37 | $387,450 | Jan 16 | 01 Distribution | false |
| 44 | Hotel for Dogs | - | - | - | $84,251 | 49 | $98,529 | Feb 20 | Universal Pictures International (UPI) | false |
| 45 | The Sicilian Girl | - | - | - | $80,570 | 53 | $199,438 | Feb 27 | Istituto Luce | false |
| 46 | Mar nero | - | - | - | $78,156 | 10 | $128,060 | Jan 30 | - | false |
| 47 | Waiting for the sun | - | - | - | $54,505 | 43 | $62,079 | Feb 20 | Mikado Film | false |
| 48 | Whisper | - | - | - | $53,072 | 73 | $502,464 | Jan 23 | Eagle Pictures | false |
| 49 | We Can Do That | - | - | - | $51,343 | 98 | $2,610,996 | Oct 31 | Warner Bros. | false |
| 50 | Mario the Magician | - | - | - | $49,574 | 12 | $238,776 | Nov 28 | L'Altrofilm | false |
| 51 | Four Christmases | - | - | - | $42,198 | 123 | $526,291 | Jan 23 | Warner Bros. | false |
| 52 | Katyn | - | - | - | $35,906 | 11 | $99,729 | Feb 13 | - | false |
| 53 | Stella | - | - | - | $29,324 | 19 | $491,218 | Dec 5 | Sacher Distribuzione | false |
| 54 | Tony Manero | - | - | - | $23,578 | 16 | $171,645 | Jan 16 | Ripley's Film | false |
| 55 | Quarantine | - | - | - | $20,885 | 10 | $63,140 | Jan 30 | Sony Pictures Releasing | false |
| 56 | Let the Right One In | - | - | - | $16,233 | 132 | $654,551 | Jan 9 | Bolero Film | false |
| 57 | Nick and Norah's Infinite Playlist | - | - | - | $15,228 | 11 | $15,228 | Feb 13 | Sony Pictures Releasing | false |
| 58 | WALL·E | - | - | - | $10,981 | 592 | $12,210,993 | Oct 17 | Walt Disney Pictures | false |
| 59 | Le premier cri | - | - | - | $5,669 | 10 | $5,669 | Feb 13 | Lucky Red | false |
| 60 | Gomorrah | - | - | - | $5,224 | 441 | $17,665,830 | May 16 | 01 Distribution | false |
| 61 | Nim's Island | - | - | - | $4,571 | 304 | $4,095,643 | Apr 11 | Moviemax | false |
| 62 | Beket | - | - | - | $4,552 | 2 | $6,482 | Jan 23 | - | false |
| 63 | Lissi und der wilde Kaiser | - | - | - | $4,487 | 156 | $597,954 | Jan 2 | Moviemax | false |
| 64 | The Pursuit of Happyness | - | - | - | $4,214 | 441 | $21,309,984 | Jan 12 | Medusa Distribuzione | false |
| 65 | Il sol dell'avvenire | - | - | - | $4,049 | 2 | $7,105 | Nov 28 | - | false |
| 66 | In the Name of the King: A Dungeon Siege Tale | - | - | - | $3,677 | 13 | $34,923 | Feb 27 | One Movie | false |
| 67 | Giovanna's Father | - | - | - | $3,456 | 357 | $4,846,636 | Sep 12 | Medusa Distribuzione | false |
| 68 | The Dark Knight | - | - | - | $2,985 | 616 | $13,871,401 | Jul 23 | Warner Bros. | false |
| 69 | Maria Venera | - | - | - | $2,608 | 4 | $2,608 | Feb 20 | - | false |
| 70 | The Hanging Garden | - | - | - | $2,481 | 2 | $23,871 | Aug 27 | Mikado Film | false |
| 71 | Puccini and the Girl | - | - | - | $2,334 | 1 | $2,334 | Feb 27 | - | false |
| 72 | Twilight | - | - | - | $1,921 | 551 | $14,410,854 | Nov 21 | Eagle Pictures | false |
| 73 | Kung Fu Panda | - | - | - | $1,220 | 669 | $22,037,818 | Aug 29 | Universal Pictures International (UPI) | false |
| 74 | Hotel Meina | - | - | - | $949 | 28 | $116,536 | Jan 25 | Mikado Film | false |
| 75 | The Duchess | - | - | - | $937 | 202 | $2,901,441 | Dec 24 | BIM Distribuzione | false |
| 76 | Nient'altro che noi | - | - | - | $917 | 1 | $2,870 | Feb 6 | - | false |
| 77 | Charlotte's Web | - | - | - | $889 | 3 | $86,446 | Mar 9 | Universal Pictures International (UPI) | false |
| 78 | Mary | - | - | - | $810 | 1 | $193,022 | Nov 11 | Mikado Film | false |
| 79 | Happy-Go-Lucky | - | - | - | $809 | 75 | $1,214,552 | Dec 5 | Mikado Film | false |
| 80 | Comme les autres | - | - | - | $719 | 17 | $194,742 | Dec 19 | Archibald | false |
| 81 | August Rush | - | - | - | $714 | 190 | $1,462,687 | Nov 30 | Medusa Distribuzione | false |
| 82 | The Class | - | - | - | $661 | 108 | $2,223,910 | Oct 10 | Mikado Film | false |
| 83 | The Fox and the Child | - | - | - | $652 | 240 | $2,400,103 | Mar 21 | Lucky Red | false |
| 84 | Alexandra | - | - | - | $479 | 7 | $77,404 | May 30 | - | false |
| 85 | Just a Father | - | - | - | $462 | 214 | $3,065,931 | Nov 28 | Warner Bros. | false |
