| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Curious Case of Benjamin Button | - | - | - | $2,189,022 | 78 | $2,941,784 | Jan 29 | Warner Bros. | false |
| 2 | Twilight | - | - | - | $1,653,462 | 82 | $2,986,625 | Nov 21 | Ascot Elite Entertainment Group | false |
| 3 | Slumdog Millionaire | - | - | - | $1,583,537 | 47 | $4,809,452 | Jan 9 | Pathé | false |
| 4 | Bolt | - | - | - | $1,016,637 | 74 | $1,782,764 | Nov 28 | Walt Disney Pictures | false |
| 5 | Revolutionary Road | - | - | - | $741,592 | 53 | $2,263,937 | Jan 15 | Universal Pictures International (UPI) | false |
| 6 | Hotel for Dogs | - | - | - | $665,096 | 49 | $937,916 | Feb 4 | Universal Pictures International (UPI) | false |
| 7 | Yes Man | - | - | - | $656,700 | 52 | $1,342,175 | Jan 9 | Warner Bros. | false |
| 8 | He's Just Not That Into You | - | - | - | $579,940 | 36 | $916,209 | Feb 12 | Warner Bros. | false |
| 9 | The International | - | - | - | $506,931 | 36 | $611,161 | Feb 12 | Walt Disney Pictures | false |
| 10 | Bride Wars | - | - | - | $473,983 | 38 | $542,622 | Feb 5 | 20th Century Fox International | false |
| 11 | Valkyrie | - | - | - | $457,717 | 72 | $1,228,347 | Jan 22 | 20th Century Fox International | false |
| 12 | Transporter 3 | - | - | - | $343,476 | 14 | $642,210 | Dec 31 | JMH Distribution | false |
| 13 | Milk | - | - | - | $311,063 | 32 | $850,531 | Jan 23 | Ascot Elite Entertainment Group | false |
| 14 | Gran Torino | - | - | - | $295,924 | 53 | $2,296,282 | Feb 25 | Warner Bros. | false |
| 15 | Friday the 13th | - | - | - | $291,662 | 27 | $314,414 | Feb 11 | Universal Pictures International (UPI) | false |
| 16 | Changeling | - | - | - | $263,403 | 41 | $1,460,706 | Nov 12 | Universal Pictures International (UPI) | false |
| 17 | Doubt | - | - | - | $252,276 | 17 | $252,857 | Jan 30 | Walt Disney Pictures | false |
| 18 | Lilly the Witch: The Dragon and the Magic Book | - | - | - | $232,944 | 45 | $508,100 | Feb 19 | Walt Disney Pictures | false |
| 19 | Madagascar: Escape 2 Africa | - | - | - | $201,126 | 152 | $11,010,683 | Dec 3 | Universal Pictures International (UPI) | false |
| 20 | The Class | - | - | - | $161,003 | 16 | $732,361 | Sep 24 | Filmcoopi Zürich | false |
| 21 | Seven Pounds | - | - | - | $151,192 | 76 | $1,666,823 | Jan 8 | Sony Pictures Releasing | false |
| 22 | Frost/Nixon | - | - | - | $149,294 | 25 | $177,851 | Feb 12 | Universal Pictures International (UPI) | false |
| 23 | The Wrestler | - | - | - | $135,147 | 20 | $262,176 | Feb 18 | Frenetic Films | false |
| 24 | Home | - | - | - | $131,544 | 15 | $979,020 | Oct 15 | Filmcoopi Zürich | false |
| 25 | The Spirit | - | - | - | $92,444 | 40 | $178,071 | Dec 26 | Walt Disney Pictures | false |
| 26 | LOL (Laughing Out Loud) | - | - | - | $89,316 | 3 | $89,316 | Feb 4 | Pathé | false |
| 27 | Le code a changé | - | - | - | $81,556 | 8 | $81,556 | Feb 18 | Frenetic Films | false |
| 28 | Role Models | - | - | - | $78,875 | 29 | $127,528 | Feb 25 | Universal Pictures International (UPI) | false |
| 29 | Killing is My Business, Honey | - | - | - | $75,259 | 22 | $125,507 | Feb 26 | Warner Bros. | false |
| 30 | The Tale of Despereaux | - | - | - | $74,492 | 38 | $191,882 | Feb 11 | Universal Pictures International (UPI) | false |
| 31 | The Pink Panther 2 | - | - | - | $72,175 | 38 | $241,728 | Feb 18 | Walt Disney Pictures | false |
| 32 | Vicky Cristina Barcelona | - | - | - | $68,612 | 25 | $2,435,699 | Oct 8 | Frenetic Films | false |
| 33 | Buddenbrooks | - | - | - | $58,820 | 14 | $768,734 | Dec 25 | Warner Bros. | false |
| 34 | Welcome to the Sticks | - | - | - | $56,096 | 28 | $9,897,101 | Feb 27 | Pathé | false |
| 35 | Wild Chicks and Life | - | - | - | $49,207 | 10 | $111,756 | Jan 29 | Pathé | false |
| 36 | District 13: Ultimatum | - | - | - | $48,645 | 5 | $48,645 | Feb 18 | Pathé | false |
| 37 | Defiance | - | - | - | $47,511 | 18 | $61,600 | Jan 23 | Ascot Elite Entertainment Group | false |
| 38 | Marcello Marcello | - | - | - | $40,845 | 21 | $397,378 | Aug 22 | Filmcoopi Zürich | false |
| 39 | Australia | - | - | - | $39,357 | 106 | $5,514,870 | Dec 24 | 20th Century Fox International | false |
| 40 | Burn After Reading | - | - | - | $32,761 | 47 | $3,021,453 | Sep 19 | Ascot Elite Entertainment Group | false |
| 41 | Fly Me to the Moon 3D | - | - | - | $31,747 | 2 | $130,523 | Oct 29 | - | false |
| 42 | The Reader | - | - | - | $12,505 | 47 | $1,495,763 | Feb 20 | Ascot Elite Entertainment Group | false |
| 43 | Inkheart | - | - | - | $4,111 | 28 | $318,918 | Dec 11 | Warner Bros. | false |
