| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Bedtime Stories | - | - | - | $1,682,089 | 79 | $2,096,916 | Feb 5 | Walt Disney Pictures | false |
| 2 | The Curious Case of Benjamin Button | - | - | - | $1,669,143 | 73 | $2,046,098 | Feb 5 | Warner Bros. | false |
| 3 | Slumdog Millionaire | - | - | - | $652,531 | 47 | $1,523,147 | Feb 12 | Distribution Company | false |
| 4 | Valkyrie | - | - | - | $607,702 | 67 | $727,580 | Feb 12 | 20th Century Fox International | false |
| 5 | Vicky Cristina Barcelona | - | - | - | $605,520 | 39 | $772,228 | Feb 5 | Pachamama Cine | false |
| 6 | Bolt | - | - | - | $602,049 | 121 | $2,103,777 | Jan 15 | Walt Disney Pictures | false |
| 7 | Yes Man | - | - | - | $493,761 | 58 | $1,324,861 | Jan 15 | Warner Bros. | false |
| 8 | Changeling | - | - | - | $412,999 | 47 | $890,990 | Jan 22 | Universal Pictures International (UPI) | false |
| 9 | Hotel for Dogs | - | - | - | $365,974 | 43 | $633,029 | Feb 19 | Paramount Pictures International | false |
| 10 | Underworld: Rise of the Lycans | - | - | - | $349,629 | 30 | $375,781 | Feb 5 | Sony Pictures Releasing | false |
| 11 | Friday the 13th | - | - | - | $268,830 | 35 | $391,821 | Feb 12 | Paramount Pictures International | false |
| 12 | Marley & Me | - | - | - | $246,532 | 59 | $637,908 | Jan 22 | 20th Century Fox International | false |
| 13 | Inkheart | - | - | - | $213,595 | 48 | $365,145 | Jan 29 | Distribution Company | false |
| 14 | The Tale of Despereaux | - | - | - | $181,810 | 56 | $176,458 | Feb 5 | United International Pictures | false |
| 15 | Milk | - | - | - | $176,657 | 33 | $238,822 | Feb 12 | Universal Pictures International (UPI) | false |
| 16 | Revolutionary Road | - | - | - | $175,263 | 31 | $290,486 | Jan 29 | Paramount Pictures International | false |
| 17 | Doubt | - | - | - | $164,551 | 30 | $538,725 | Jan 15 | Walt Disney Pictures | false |
| 18 | The Pink Panther 2 | - | - | - | $152,029 | 27 | $242,323 | Feb 19 | Sony Pictures Releasing | false |
| 19 | The Wrestler | - | - | - | $151,505 | 30 | $191,690 | Feb 20 | Distribution Company | false |
| 20 | Australia | - | - | - | $136,442 | 64 | $856,824 | Jan 8 | 20th Century Fox International | false |
| 21 | Twilight | - | - | - | $128,885 | 88 | $1,844,290 | Jan 1 | Alfa Films | false |
| 22 | Bride Wars | - | - | - | $106,676 | 43 | $390,434 | Feb 26 | 20th Century Fox International | false |
| 23 | Madagascar: Escape 2 Africa | - | - | - | $79,310 | 156 | $5,066,136 | Dec 4 | Paramount Pictures International | false |
| 24 | La próxima estación | - | - | - | $76,480 | 13 | $120,249 | Sep 4 | Primer Plano Film Group | false |
| 25 | Seven Pounds | - | - | - | $71,096 | 28 | $263,090 | Feb 26 | Sony Pictures Releasing | false |
| 26 | The Day the Earth Stood Still | - | - | - | $69,016 | 122 | $2,100,530 | Jan 1 | 20th Century Fox International | false |
| 27 | Fly Me to the Moon 3D | - | - | - | $51,000 | 45 | $31,665 | Dec 18 | Distribution Company | false |
| 28 | Beverly Hills Chihuahua | - | - | - | $42,031 | 61 | $1,559,499 | Oct 9 | Walt Disney Pictures | false |
| 29 | Burn After Reading | - | - | - | $41,277 | 51 | $882,934 | Oct 23 | United International Pictures | false |
| 30 | Frost/Nixon | - | - | - | $37,454 | 15 | $43,972 | Feb 19 | United International Pictures | false |
| 31 | Saw V | - | - | - | $27,555 | 62 | $1,076,755 | Oct 30 | Walt Disney Pictures | false |
| 32 | Mamma Mia! | - | - | - | $22,864 | 50 | $178,082 | Aug 21 | United International Pictures | false |
| 33 | Bangkok Dangerous | - | - | - | $22,697 | 31 | $125,330 | Jan 15 | Distribution Company | false |
| 34 | El ratón Pérez 2 | - | - | - | $18,950 | 98 | $704,487 | Jan 1 | Walt Disney Pictures | false |
| 35 | Death Proof | - | - | - | $18,807 | 14 | $47,515 | Feb 26 | Pachamama Cine | false |
| 36 | Emma's Bliss | - | - | - | $16,577 | 5 | $26,523 | Jan 29 | Primer Plano Film Group | false |
| 37 | Blame it on Fidel | - | - | - | $14,029 | 7 | $38,824 | Jan 22 | Zeta Films | false |
| 38 | The Duchess | - | - | - | $13,291 | 15 | $263,387 | Dec 11 | United International Pictures | false |
| 39 | The Spirit | - | - | - | $12,781 | 26 | $108,192 | Jan 22 | Sony Pictures Releasing | false |
| 40 | Body of Lies | - | - | - | $11,346 | 49 | $930,022 | Nov 27 | Warner Bros. | false |
| 41 | Rudo y Cursi | - | - | - | $9,570 | 45 | $310,389 | Jan 8 | United International Pictures | false |
| 42 | Quarantine | - | - | - | $7,730 | 30 | $376,330 | Dec 4 | Sony Pictures Releasing | false |
| 43 | Righteous Kill | - | - | - | $7,712 | 44 | $580,788 | Nov 20 | CDI Films | false |
| 44 | L'année suivante | - | - | - | $6,190 | 4 | $12,627 | Feb 26 | Zeta Films | false |
| 45 | W. | - | - | - | $5,919 | 13 | $65,346 | Jan 15 | Impacto Cine | false |
| 46 | Four Christmases | - | - | - | $5,532 | 41 | $419,584 | Dec 18 | Distribution Company | false |
| 47 | Che: Part One | - | - | - | $5,084 | 56 | $669,305 | Nov 13 | Alfa Films | false |
| 48 | RocknRolla | - | - | - | $3,376 | 15 | $92,024 | Dec 11 | Warner Bros. | false |
| 49 | Am Ende kommen Touristen | - | - | - | $3,249 | 4 | $14,943 | Feb 19 | Alfa Films | false |
| 50 | Late Bloomers | - | - | - | $2,649 | 7 | $77,398 | Nov 27 | Primer Plano Film Group | false |
| 51 | The Boy in the Striped Pajamas | - | - | - | $2,611 | 13 | $86,300 | Dec 4 | Walt Disney Pictures | false |
| 52 | Deception | - | - | - | $2,018 | 13 | $68,776 | Dec 11 | Alfa Films | false |
| 53 | Fados | - | - | - | $1,920 | 6 | $37,153 | Nov 27 | Distribution Company | false |
| 54 | Journey to the Center of the Earth | - | - | - | $1,568 | 55 | $1,311,200 | Jul 17 | Distribution Company | false |
| 55 | Aniceto | - | - | - | $1,477 | 32 | $134,481 | Jun 12 | Primer Plano Film Group | false |
| 56 | Planet Terror | - | - | - | $1,204 | 24 | $94,001 | Dec 11 | Pachamama Cine | false |
| 57 | WALL·E | - | - | - | $1,176 | 167 | $4,664,019 | Jul 10 | Walt Disney Pictures | false |
| 58 | Tear This Heart Out | - | - | - | $1,123 | 7 | $57,357 | Nov 27 | 20th Century Fox International | false |
| 59 | Manual of Love 2008 Re-release | - | - | - | $1,097 | 9 | $136,530 | Sep 25 | Notro Films | false |
| 60 | The Pope's Toilet | - | - | - | $513 | 7 | $28,065 | Jan 1 | Primer Plano Film Group | false |
| 61 | High School Musical 3: Senior Year | - | - | - | $400 | 124 | $1,314,788 | Nov 27 | Walt Disney Pictures | false |
| 62 | The Tracker 2008 Re-release | - | - | - | $363 | 5 | $168,175 | Dec 25 | IFA | false |
| 63 | Shara | - | - | - | $356 | 7 | $44,065 | Oct 30 | Zeta Films | false |
| 64 | Two Friends and a Burglar | - | - | - | $284 | 4 | $10,128 | Nov 27 | Primer Plano Film Group | false |
| 65 | A Boyfriend for My Wife | - | - | - | $248 | 91 | $5,655,910 | Aug 14 | Walt Disney Pictures | false |
| 66 | Asterix at the Olympic Games | - | - | - | $229 | 34 | $47,752 | Jan 8 | Distribution Company | false |
| 67 | Bella | - | - | - | $158 | 8 | $31,226 | Dec 25 | CDI Films | false |
| 68 | Reasons for Not Falling in Love | - | - | - | $148 | 44 | $542,931 | Sep 4 | Distribution Company | false |
| 69 | The Paranoids | - | - | - | $122 | 20 | $38,597 | Oct 23 | Primer Plano Film Group | false |
| 70 | El último bandoneón | - | - | - | $112 | 1 | $4,871 | Oct 19 | Primer Plano Film Group | false |
| 71 | La leyenda | - | - | - | $101 | 48 | $206,591 | Nov 20 | United International Pictures | false |
| 72 | Elegy | - | - | - | $92 | 22 | $175,398 | Nov 20 | Distribution Company | false |
| 73 | Bug | - | - | - | $86 | 3 | $6,619 | Jan 15 | Alfa Films | false |
