| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Pink Panther 2 | - | - | - | $697,365 | 19 | $846,694 | Feb 12 | - | false |
| 2 | The Unborn | - | - | - | $505,162 | 20 | $512,033 | Feb 5 | - | false |
| 3 | The Curious Case of Benjamin Button | - | - | - | $496,940 | 24 | $615,943 | Feb 19 | - | false |
| 4 | Slumdog Millionaire | - | - | - | $482,919 | 23 | $1,319,117 | Jan 22 | Gulf Film | false |
| 5 | Confessions of a Shopaholic | - | - | - | $278,970 | 16 | $361,219 | Feb 19 | - | false |
| 6 | Inkheart | - | - | - | $265,041 | 19 | $265,041 | Feb 5 | - | false |
| 7 | The International | - | - | - | $234,154 | 19 | $421,084 | Feb 26 | - | false |
| 8 | Yes Man | - | - | - | $183,878 | 20 | $738,370 | Jan 22 | - | false |
| 9 | The Tattooist | - | - | - | $180,442 | 16 | $189,218 | Feb 19 | - | false |
| 10 | The Tale of Despereaux | - | - | - | $167,707 | 20 | $304,498 | Jan 29 | - | false |
| 11 | Killshot | - | - | - | $152,432 | 12 | $152,432 | Feb 5 | - | false |
| 12 | Solstice | - | - | - | $144,236 | 19 | $144,236 | Feb 12 | - | false |
| 13 | Seven Pounds | - | - | - | $137,150 | 19 | $275,653 | Jan 29 | - | false |
| 14 | Day of the Dead | - | - | - | $132,589 | 20 | $223,460 | Feb 26 | - | false |
| 15 | Role Models | - | - | - | $129,733 | 11 | $135,192 | Feb 12 | - | false |
| 16 | The Spirit | - | - | - | $97,402 | 20 | $271,519 | Jan 29 | - | false |
| 17 | Quarantine | - | - | - | $93,992 | 19 | $93,992 | Feb 19 | - | false |
| 18 | Appaloosa | - | - | - | $86,721 | 15 | $86,721 | Feb 12 | - | false |
| 19 | Garfield's Fun Fest | - | - | - | $86,602 | 17 | $124,361 | Feb 19 | - | false |
| 20 | How to Lose Friends & Alienate People | - | - | - | $81,784 | 13 | $81,784 | Feb 5 | - | false |
| 21 | My Mom's New Boyfriend | - | - | - | $79,633 | 14 | $168,038 | Jan 29 | - | false |
| 22 | Underworld: Rise of the Lycans | - | - | - | $68,207 | 19 | $471,453 | Jan 22 | - | false |
| 23 | Shikamara | - | - | - | $66,351 | 14 | $66,351 | Feb 5 | - | false |
| 24 | Sorry to Disturb | - | - | - | $59,911 | 20 | $400,981 | Jan 22 | - | false |
| 25 | Penelope | - | - | - | $41,551 | 14 | $62,597 | Feb 26 | - | false |
| 26 | The Wrestler | - | - | - | $31,725 | 11 | $31,725 | Feb 12 | - | false |
| 27 | Valkyrie | - | - | - | $31,357 | 20 | $585,039 | Jan 15 | - | false |
| 28 | The Children of Huang Shi | - | - | - | $28,080 | 12 | $46,301 | Feb 26 | - | false |
| 29 | Revolutionary Road | - | - | - | $22,655 | 19 | $120,826 | Jan 22 | - | false |
| 30 | Bride Wars | - | - | - | $21,157 | 19 | $342,172 | Jan 15 | - | false |
| 31 | Madagascar: Escape 2 Africa | - | - | - | $21,149 | 27 | $1,908,261 | Nov 27 | - | false |
| 32 | Hasan Tayyarah | - | - | - | $20,660 | 10 | $33,551 | Feb 26 | - | false |
| 33 | Amusement | - | - | - | $19,260 | 13 | $64,676 | Jan 29 | - | false |
| 34 | Frost/Nixon | - | - | - | $18,616 | 11 | $18,616 | Feb 26 | - | false |
| 35 | Hosh Ala Wakah Mink | - | - | - | $14,395 | 8 | $18,644 | Feb 12 | - | false |
| 36 | The Fall | - | - | - | $14,037 | 7 | $14,037 | Feb 5 | - | false |
| 37 | Twilight | - | - | - | $10,558 | 21 | $1,257,768 | Dec 4 | - | false |
| 38 | Changeling | - | - | - | $5,919 | 20 | $278,077 | Jan 8 | - | false |
| 39 | Bolt | - | - | - | $4,853 | 16 | $467,860 | Dec 4 | - | false |
| 40 | City of Ember | - | - | - | $1,946 | 15 | $209,560 | Jan 8 | - | false |
