| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Night at the Museum | - | - | - | $1,798,908 | 101 | $2,891,900 | Feb 15 | 20th Century Fox International | false |
| 2 | Blood Diamond | - | - | - | $1,723,491 | 80 | $3,165,003 | Jan 25 | Warner Bros. | false |
| 3 | Ernst, Bobbie en de geslepen Onix | - | - | - | $1,106,168 | 108 | $1,813,252 | Feb 15 | Independent Films | false |
| 4 | The Pursuit of Happyness | - | - | - | $1,090,907 | 33 | $1,340,879 | Feb 1 | Sony Pictures Releasing | false |
| 5 | Casino Royale | - | - | - | $689,295 | 132 | $10,598,499 | Nov 23 | Sony Pictures Releasing | false |
| 6 | Smokin' Aces | - | - | - | $649,723 | 40 | $746,194 | Feb 1 | Universal Pictures International (UPI) | false |
| 7 | Barnyard | - | - | - | $637,058 | 74 | $1,161,390 | Feb 15 | Universal Pictures International (UPI) | false |
| 8 | The Prestige | - | - | - | $610,104 | 31 | $757,704 | Feb 8 | Warner Bros. | false |
| 9 | Happy Feet | - | - | - | $596,006 | 171 | $7,515,003 | Dec 7 | Warner Bros. | false |
| 10 | Arthur and the Invisibles | - | - | - | $571,140 | 86 | $754,493 | Feb 1 | Independent Films | false |
| 11 | The Good Shepherd | - | - | - | $471,113 | 59 | $778,913 | Feb 15 | Benelux Film Distributors | false |
| 12 | Dreamgirls | - | - | - | $421,823 | 41 | $1,018,310 | Feb 22 | Universal Pictures International (UPI) | false |
| 13 | Babel | - | - | - | $395,634 | 36 | $2,290,813 | Nov 2 | Independent Films | false |
| 14 | Black Book | - | - | - | $354,651 | 94 | $10,058,486 | Sep 14 | A-Film Distribution | false |
| 15 | The Holiday | - | - | - | $353,374 | 96 | $4,782,861 | Dec 14 | United International Pictures | false |
| 16 | The Queen | - | - | - | $343,360 | 27 | $1,611,751 | Nov 30 | A-Film Distribution | false |
| 17 | The Last King of Scotland | - | - | - | $280,740 | 15 | $615,943 | Feb 8 | 20th Century Fox International | false |
| 18 | Crusade in Jeans | - | - | - | $274,047 | 134 | $4,055,422 | Nov 16 | Benelux Film Distributors | false |
| 19 | Perfume: The Story of a Murderer | - | - | - | $248,131 | 53 | $1,884,253 | Dec 7 | RCV Film Distribution | false |
| 20 | Happy Family | - | - | - | $197,355 | 58 | $1,271,669 | Dec 14 | RCV Film Distribution | false |
| 21 | Charlotte's Web | - | - | - | $184,335 | 117 | $1,680,259 | Dec 21 | United International Pictures | false |
| 22 | Apocalypto | - | - | - | $177,554 | 81 | $1,121,164 | Jan 11 | A-Film Distribution | false |
| 23 | Little Children | - | - | - | $167,177 | 17 | $259,400 | Jan 25 | A-Film Distribution | false |
| 24 | Deja Vu | - | - | - | $133,666 | 71 | $2,563,987 | Dec 14 | Buena Vista International | false |
| 25 | Miss Potter | - | - | - | $115,212 | 51 | $147,130 | Feb 8 | RCV Film Distribution | false |
| 26 | Notes on a Scandal | - | - | - | $89,005 | 12 | $324,068 | Feb 22 | 20th Century Fox International | false |
| 27 | Saw III | - | - | - | $50,395 | 62 | $1,579,557 | Jan 4 | Independent Films | false |
| 28 | Rocky Balboa | - | - | - | $49,506 | 60 | $525,969 | Jan 18 | 20th Century Fox International | false |
| 29 | Ten Canoes | - | - | - | $32,993 | 13 | $37,436 | Feb 1 | Cinemien | false |
| 30 | Letters from Iwo Jima | - | - | - | $22,590 | 20 | $22,590 | Feb 15 | Warner Bros. | false |
