| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Spud | - | - | - | $2,015,041 | 85 | $2,316,147 | Dec 3 | NuMetro Distribution | false |
| 2 | Megamind | - | - | - | $1,753,975 | 79 | $1,895,039 | Dec 15 | United International Pictures | false |
| 3 | The Chronicles of Narnia: The Voyage of the Dawn Treader | - | - | - | $1,692,845 | 113 | $1,931,605 | Dec 10 | NuMetro Distribution | false |
| 4 | Harry Potter and the Deathly Hallows: Part 1 | - | - | - | $1,468,425 | 112 | $2,268,033 | Nov 26 | NuMetro Distribution | false |
| 5 | Liefling | - | - | - | $1,174,566 | 97 | $1,842,887 | Nov 19 | Indigenous Film Distribution | false |
| 6 | Due Date | - | - | - | $892,178 | 61 | $1,342,183 | Dec 15 | NuMetro Distribution | false |
| 7 | Little Fockers | - | - | - | $736,631 | 72 | $1,977,706 | Dec 24 | United International Pictures | false |
| 8 | RED | - | - | - | $474,596 | 45 | $815,188 | Nov 19 | NuMetro Distribution | false |
| 9 | Faster | - | - | - | $451,460 | 41 | $499,347 | Dec 3 | Ster-Kinekor Pictures | false |
| 10 | Unstoppable | - | - | - | $420,492 | 61 | $963,953 | Nov 12 | NuMetro Distribution | false |
| 11 | The American | - | - | - | $294,537 | 40 | $293,888 | Dec 3 | Ster-Kinekor Pictures | false |
| 12 | Despicable Me | - | - | - | $292,997 | 86 | $2,345,587 | Oct 1 | United International Pictures | false |
| 13 | Life as We Know It | - | - | - | $271,033 | 70 | $1,172,038 | Oct 29 | NuMetro Distribution | false |
| 14 | Jackass 3D | - | - | - | $255,520 | 34 | $506,596 | Nov 19 | United International Pictures | false |
| 15 | Paranormal Activity 2 | - | - | - | $211,253 | 15 | $246,354 | Dec 10 | United International Pictures | false |
| 16 | Stoute Boudjies | - | - | - | $192,692 | 40 | $195,054 | Dec 10 | Ster-Kinekor Pictures | false |
| 17 | Yogi Bear | - | - | - | $169,364 | 52 | $339,389 | Dec 24 | NuMetro Distribution | false |
| 18 | Eat Pray Love | - | - | - | $148,195 | 84 | $1,826,482 | Oct 8 | Sony Pictures Releasing | false |
| 19 | You Again | - | - | - | $142,473 | 30 | $394,708 | Nov 5 | Ster-Kinekor Pictures | false |
| 20 | Takers 2010 Re-release | - | - | - | $113,072 | 40 | $460,076 | Oct 29 | Ster-Kinekor Pictures | false |
| 21 | The Social Network | - | - | - | $88,847 | 40 | $415,980 | Nov 5 | Ster-Kinekor Pictures | false |
| 22 | Scott Pilgrim vs. the World | - | - | - | $86,537 | 15 | $86,677 | Dec 3 | United International Pictures | false |
| 23 | The Other Guys | - | - | - | $62,490 | 56 | $1,204,080 | Sep 24 | Sony Pictures Releasing | false |
| 24 | Eternity | - | - | - | $40,436 | 28 | $50,365 | Dec 24 | Indigenous Film Distribution | false |
| 25 | Coco Chanel & Igor Stravinsky | - | - | - | $32,732 | 6 | $43,142 | Nov 26 | United International Pictures | false |
| 26 | The Girl Who Kicked the Hornet's Nest | - | - | - | $30,111 | 10 | $30,809 | Dec 10 | NuMetro Distribution | false |
| 27 | Why Did I Get Married Too? | - | - | - | $28,877 | 40 | $558,754 | Oct 1 | Ster-Kinekor Pictures | false |
| 28 | The Girl with the Dragon Tattoo | - | - | - | $28,618 | 15 | $276,717 | Oct 15 | NuMetro Distribution | false |
| 29 | The Kids Are All Right | - | - | - | $25,629 | 3 | $58,624 | Nov 12 | United International Pictures | false |
| 30 | The Girl Who Played with Fire | - | - | - | $24,678 | 14 | $148,095 | Nov 5 | NuMetro Distribution | false |
| 31 | Break Ke Baad | - | - | - | $20,002 | 6 | $35,021 | Nov 26 | NuMetro Distribution | false |
| 32 | Charlie St. Cloud | - | - | - | $17,857 | 45 | $291,268 | Oct 22 | United International Pictures | false |
| 33 | The Crazies | - | - | - | $13,748 | 34 | $77,597 | Nov 12 | United International Pictures | false |
| 34 | Wolf 2010 Re-release | - | - | - | $9,465 | 4 | $11,996 | Dec 24 | Ster-Kinekor Pictures | false |
| 35 | Eyes Wide Open | - | - | - | $8,402 | 2 | $30,933 | Nov 12 | United International Pictures | false |
