| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Natale a Beverly Hills | - | - | - | $23,444,225 | 621 | $29,916,370 | Dec 18 | Filmauro | false |
| 2 | A Christmas Carol | - | - | - | $20,876,192 | 504 | $22,530,311 | Dec 3 | Walt Disney Pictures | false |
| 3 | Cado dalle nubi | - | - | - | $14,359,948 | 430 | $19,573,511 | Nov 27 | Medusa Distribuzione | false |
| 4 | Me and Marilyn | - | - | - | $12,690,277 | 563 | $18,842,502 | Dec 18 | Medusa Distribuzione | false |
| 5 | Sherlock Holmes | - | - | - | $10,572,548 | 394 | $26,955,437 | Dec 25 | Warner Bros. | false |
| 6 | The Princess and the Frog | - | - | - | $8,443,330 | 446 | $13,157,233 | Dec 18 | Walt Disney Pictures | false |
| 7 | Dorian Gray | - | - | - | $6,081,636 | 238 | $8,249,394 | Nov 27 | Eagle Pictures | false |
| 8 | Cloudy with a Chance of Meatballs | - | - | - | $3,688,061 | 308 | $6,448,099 | Dec 23 | Sony Pictures Releasing | false |
| 9 | The Twilight Saga: New Moon | - | - | - | $3,298,583 | 699 | $20,609,171 | Nov 18 | Eagle Pictures | false |
| 10 | A Serious Man | - | - | - | $3,231,452 | 249 | $3,644,266 | Dec 4 | Medusa Distribuzione | false |
| 11 | 2012 | - | - | - | $2,308,889 | 577 | $21,086,983 | Nov 13 | Sony Pictures Releasing | false |
| 12 | The Ugly Truth | - | - | - | $2,213,070 | 205 | $3,210,325 | Nov 27 | Sony Pictures Releasing | false |
| 13 | Couples Retreat | - | - | - | $2,115,759 | 210 | $2,115,759 | Dec 4 | United International Pictures | false |
| 14 | The Cézanne Affair/The Man Who Will Come | - | - | - | $2,022,233 | 253 | $2,239,181 | Dec 4 | 01 Distribution | false |
| 15 | Brothers | - | - | - | $1,747,110 | 201 | $3,266,025 | Dec 23 | 01 Distribution | false |
| 16 | Planet 51 | - | - | - | $1,221,937 | 255 | $3,405,781 | Nov 20 | - | false |
| 17 | Looking for Eric | - | - | - | $1,195,005 | 80 | $2,330,354 | Dec 4 | BIM Distribuzione | false |
| 18 | Amelia | - | - | - | $1,032,827 | 177 | $1,604,777 | Dec 23 | 20th Century Fox International | false |
| 19 | Astro Boy | - | - | - | $686,362 | 216 | $696,229 | Dec 18 | Eagle Pictures | false |
| 20 | Broken Embraces | - | - | - | $607,643 | 351 | $5,199,445 | Nov 13 | Warner Bros. | false |
| 21 | Jennifer's Body | - | - | - | $558,574 | 169 | $584,320 | Dec 11 | 20th Century Fox International | false |
| 22 | The Front Line | - | - | - | $553,677 | 157 | $1,505,991 | Nov 20 | Lucky Red | false |
| 23 | Ninja Assassin | - | - | - | $533,312 | 111 | $533,312 | Dec 4 | Warner Bros. | false |
| 24 | Welcome | - | - | - | $491,174 | 40 | $1,253,705 | Dec 11 | Teodora Film | false |
| 25 | Public Enemies | - | - | - | $384,263 | 395 | $8,491,750 | Nov 6 | United International Pictures | false |
| 26 | The Men Who Stare at Goats | - | - | - | $373,234 | 274 | $5,577,762 | Nov 6 | Medusa Distribuzione | false |
| 27 | Meno male che ci sei | - | - | - | $344,367 | 200 | $861,493 | Nov 27 | United International Pictures | false |
| 28 | Up | - | - | - | $305,315 | 652 | $22,494,067 | Oct 15 | Walt Disney Pictures | false |
| 29 | Ten Winters | - | - | - | $271,709 | - | $688,027 | Dec 11 | - | false |
| 30 | 500 Days of Summer | - | - | - | $229,000 | 94 | $411,731 | Nov 27 | 20th Century Fox International | false |
| 31 | Tetro | - | - | - | $197,291 | 67 | $631,756 | Nov 20 | BIM Distribuzione | false |
| 32 | Moon | - | - | - | $111,967 | 11 | $155,407 | Dec 4 | Sony Pictures Releasing | false |
| 33 | Julie & Julia | - | - | - | $75,504 | 153 | $3,006,094 | Oct 23 | Sony Pictures Releasing | false |
| 34 | Land of the Lost | - | - | - | $62,594 | 98 | $62,693 | Dec 11 | Teodora Film | false |
| 35 | The Wedding Song | - | - | - | $62,055 | 11 | $148,452 | Dec 18 | - | false |
| 36 | The White Ribbon | - | - | - | $37,897 | 6 | $844,455 | Oct 30 | Lucky Red | false |
| 37 | Whatever Works | - | - | - | $34,075 | 329 | $7,399,626 | Sep 18 | Medusa Distribuzione | false |
| 38 | The Imaginarium of Doctor Parnassus | - | - | - | $32,643 | 283 | $11,119,996 | Oct 23 | - | false |
| 39 | Valentino: The Last Emperor | - | - | - | $22,201 | 7 | $211,275 | Nov 20 | Medusa Distribuzione | false |
| 40 | Baaria | - | - | - | $19,715 | 527 | $14,686,170 | Sep 25 | Medusa Distribuzione | false |
| 41 | Inglourious Basterds | - | - | - | $17,661 | 465 | $13,380,924 | Oct 2 | United International Pictures | false |
| 42 | Francesca 2009 Re-release | - | - | - | $16,013 | 22 | $91,267 | Nov 27 | Fandango | false |
| 43 | Stolen Summer | - | - | - | $6,924 | 6 | $27,940 | Jul 25 | Walt Disney Pictures | false |
| 44 | A Summer in Genoa | - | - | - | $4,381 | 6 | $97,471 | Oct 16 | - | false |
| 45 | The Wave | - | - | - | $3,642 | 57 | $696,752 | Feb 27 | BIM Distribuzione | false |
| 46 | Slumdog Millionaire | - | - | - | $2,095 | 160 | $9,341,549 | Dec 5 | Lucky Red | false |
