| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Avatar | - | - | - | $34,740,791 | 800 | $107,309,094 | Dec 18 | 20th Century Fox International | false |
| 2 | Planet 51 | - | - | - | $10,723,671 | 509 | $15,762,612 | Nov 27 | DeAPlaneta | false |
| 3 | Spanish Movie | - | - | - | $10,090,785 | 389 | $10,875,184 | Dec 4 | 20th Century Fox International | false |
| 4 | Sorority Row | - | - | - | $7,787,224 | 211 | $7,787,224 | Dec 4 | Aurum Films | false |
| 5 | The Twilight Saga: New Moon | - | - | - | $6,298,820 | 636 | $28,617,897 | Nov 20 | Aurum Films | false |
| 6 | Cloudy with a Chance of Meatballs | - | - | - | $6,248,167 | 491 | $7,000,967 | Dec 4 | Sony Pictures Releasing | false |
| 7 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $5,547,589 | 355 | $12,983,049 | Dec 25 | 20th Century Fox International | false |
| 8 | Old Dogs | - | - | - | $5,285,975 | 325 | $5,689,108 | Dec 4 | Walt Disney Pictures | false |
| 9 | Cell 211 | - | - | - | $5,087,748 | 220 | $15,905,730 | Nov 6 | Paramount Pictures International | false |
| 10 | 2012 | - | - | - | $5,016,501 | 606 | $22,591,580 | Nov 13 | Sony Pictures Releasing | false |
| 11 | It's Complicated | - | - | - | $2,877,470 | 327 | $6,352,243 | Dec 25 | United International Pictures | false |
| 12 | Zombieland | - | - | - | $2,011,562 | 250 | $3,351,911 | Dec 25 | Sony Pictures Releasing | false |
| 13 | A Christmas Carol | - | - | - | $1,891,809 | 427 | $8,321,029 | Nov 13 | Walt Disney Pictures | false |
| 14 | Paranormal Activity | - | - | - | $1,865,059 | 205 | $2,679,752 | Nov 27 | Warner Bros. | false |
| 15 | The Dancer and the Thief | - | - | - | $1,601,700 | 200 | $2,172,688 | Nov 27 | Notro Films | false |
| 16 | Fame | - | - | - | $1,514,728 | 276 | $2,484,548 | Dec 23 | Filmax | false |
| 17 | What Just Happened | - | - | - | $1,253,256 | 150 | $1,281,684 | Dec 11 | Filmax | false |
| 18 | The Hedgehog | - | - | - | $1,170,089 | 96 | $1,789,908 | Dec 11 | Alta Films | false |
| 19 | Where the Wild Things Are | - | - | - | $1,013,284 | 150 | $1,409,497 | Dec 18 | Warner Bros. | false |
| 20 | Armored | - | - | - | $970,954 | 141 | $1,012,414 | Dec 11 | Sony Pictures Releasing | false |
| 21 | Ninja Assassin | - | - | - | $799,153 | 204 | $1,147,360 | Dec 23 | Warner Bros. | false |
| 22 | The Flight Before Christmas | - | - | - | $603,202 | 145 | $1,364,775 | Dec 23 | Filmax | false |
| 23 | In the Loop | - | - | - | $472,840 | 35 | $611,245 | Dec 4 | - | false |
| 24 | Whatever Works | - | - | - | $378,429 | 196 | $5,590,384 | Oct 2 | TriPictures | false |
| 25 | The Girl Who Played with Fire | - | - | - | $256,554 | 360 | $7,772,456 | Oct 23 | Vértigo Films | false |
| 26 | Amelia | - | - | - | $254,749 | 301 | $1,644,943 | Nov 20 | 20th Century Fox International | false |
| 27 | Blame It on Mum | - | - | - | $178,052 | 28 | $270,482 | Dec 18 | Golem Distribución | false |
| 28 | Julie & Julia | - | - | - | $75,638 | 206 | $2,597,806 | Nov 6 | Sony Pictures Releasing | false |
| 29 | Garbo: The Spy | - | - | - | $38,591 | 18 | $319,279 | Dec 4 | - | false |
| 30 | The Imaginarium of Doctor Parnassus | - | - | - | $33,267 | 71 | $1,342,851 | Oct 23 | Sony Pictures Releasing | false |
| 31 | Bad Day to Go Fishing | - | - | - | $22,262 | 14 | $142,181 | Dec 11 | Notro Films | false |
