| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Max Th | Opening | % of Total
| Open Th | Open | Close | Distributor
| Estimated
|
|---|
| 1 | Gran Torino | - | - | - | $148,095,302 | 3,045 | $271,720 | 0.2% | 6 | Dec 12 | Jun 18 | Warner Bros. | false |
| 2 | Marley & Me | - | - | - | $143,153,751 | 3,505 | $36,357,586 | 25.4% | 3,480 | Dec 25 | Apr 30 | Twentieth Century Fox | false |
| 3 | The Curious Case of Benjamin Button | - | - | - | $127,509,326 | 2,988 | $26,853,816 | 21.1% | 2,988 | Dec 25 | Apr 23 | Paramount Pictures | false |
| 4 | Bedtime Stories | - | - | - | $110,101,975 | 3,684 | $27,450,296 | 24.9% | 3,681 | Dec 25 | Mar 12 | Walt Disney Studios Motion Pictures | false |
| 5 | Yes Man | - | - | - | $97,690,976 | 3,434 | $18,262,471 | 18.7% | 3,434 | Dec 19 | Apr 2 | Warner Bros. | false |
| 6 | Valkyrie | - | - | - | $83,077,833 | 2,838 | $21,027,007 | 25.3% | 2,711 | Dec 25 | Apr 16 | United Artists | false |
| 7 | The Day the Earth Stood Still | - | - | - | $79,366,978 | 3,560 | $30,480,153 | 38.4% | 3,560 | Dec 12 | Apr 2 | Twentieth Century Fox | false |
| 8 | Seven Pounds | - | - | - | $69,951,824 | 2,758 | $14,851,136 | 21.2% | 2,758 | Dec 19 | Jan 25 | Sony Pictures Releasing | false |
| 9 | The Tale of Despereaux | - | - | - | $50,877,145 | 3,107 | $10,103,675 | 19.9% | 3,104 | Dec 19 | Mar 5 | Universal Pictures | false |
| 10 | The Reader | - | - | - | $34,194,407 | 1,203 | $168,051 | 0.5% | 8 | Dec 10 | May 13 | The Weinstein Company | false |
| 11 | Doubt | - | - | - | $33,446,470 | 1,287 | $507,226 | 1.5% | 15 | Dec 12 | Apr 9 | Miramax | false |
| 12 | Defiance | - | - | - | $28,644,813 | 1,793 | $123,513 | 0.4% | 2 | Dec 31 | Apr 30 | Paramount Vantage | false |
| 13 | The Wrestler | - | - | - | $26,238,243 | 776 | $202,714 | 0.8% | 4 | Dec 17 | May 14 | Fox Searchlight Pictures | false |
| 14 | Revolutionary Road | - | - | - | $22,911,480 | 1,077 | $189,911 | 0.8% | 3 | Dec 26 | Apr 2 | Paramount Vantage | false |
| 15 | The Spirit | - | - | - | $19,806,188 | 2,509 | $6,463,278 | 32.6% | 2,509 | Dec 25 | Jan 22 | Lionsgate | false |
| 16 | Frost/Nixon | - | - | - | $18,622,031 | 1,105 | $180,708 | 1% | 3 | Dec 5 | Mar 26 | Universal Pictures | false |
| 17 | Last Chance Harvey | - | - | - | $14,889,042 | 1,108 | $97,260 | 0.7% | 6 | Dec 25 | Apr 23 | Overture Films | false |
| 18 | Cadillac Records | - | - | - | $8,195,551 | 701 | $3,445,559 | 42% | 687 | Dec 5 | Jan 8 | Sony Pictures Releasing | false |
| 19 | Punisher: War Zone | - | - | - | $8,050,977 | 2,508 | $4,271,451 | 53.1% | 2,508 | Dec 5 | Dec 24 | Lionsgate | false |
| 20 | Nothing Like the Holidays | - | - | - | $7,503,736 | 1,671 | $3,531,664 | 47.1% | 1,671 | Dec 12 | Jan 29 | Overture Films | false |
| 21 | The Class | - | - | - | $3,766,810 | 126 | - | - | - | Dec 19 | Jun 11 | Sony Pictures Classics | false |
| 22 | Ghajini | - | - | - | $2,430,627 | 83 | $766,859 | 31.5% | 83 | Dec 24 | Jan 29 | Adlabs Films | false |
| 23 | Waltz with Bashir | - | - | - | $2,283,849 | 208 | $50,021 | 2.2% | 5 | Dec 25 | May 14 | Sony Pictures Classics | false |
| 24 | Rab Ne Bana Di Jodi | - | - | - | $2,078,956 | 83 | $920,995 | 44.3% | 83 | Dec 12 | Jan 15 | Yash Raj Films | false |
| 25 | Gomorrah | - | - | - | $1,579,146 | 50 | $5,532 | 0.4% | 1 | Dec 19 | Jun 11 | IFC Films | false |
| 26 | Che: Part One/Che: Part Two | - | - | - | $1,497,109 | 39 | $61,070 | 4.1% | 2 | Dec 12 | May 21 | IFC Films | false |
| 27 | Wendy and Lucy | - | - | - | $865,695 | 40 | $18,218 | 2.1% | 2 | Dec 10 | Apr 30 | Oscilloscope | false |
| 28 | Delgo | - | - | - | $694,782 | 2,160 | $511,920 | 73.7% | 2,160 | Dec 12 | Dec 18 | Freestyle Releasing | false |
| 29 | Nobel Son | - | - | - | $540,382 | 893 | $333,912 | 61.8% | 893 | Dec 5 | Dec 24 | Freestyle Releasing | false |
| 30 | Hunger | - | - | - | $154,084 | 11 | $1,980 | 1.3% | 1 | Dec 5 | Jun 7 | IFC Films | false |
| 31 | The Secret of the Grain | - | - | - | $86,356 | 3 | $9,850 | 11.4% | 1 | Dec 24 | Mar 1 | IFC Films | false |
| 32 | $9.99 | - | - | - | $52,384 | 4 | $478 | 0.9% | 1 | Dec 12 | Jan 21 | Regent Releasing | false |
| 33 | Ciao | - | - | - | $49,494 | 3 | $2,672 | 5.4% | 1 | Dec 5 | Jun 11 | Regent Releasing | false |
| 34 | Timecrimes | - | - | - | $39,127 | 7 | $4,351 | 11.1% | 2 | Dec 12 | Jan 29 | Magnolia Pictures | false |
| 35 | Don Carlo | - | - | - | $27,834 | 5 | $27,834 | 100% | 5 | Dec 5 | Dec 7 | Emerging Pictures | false |
| 36 | Good | - | - | - | $27,276 | 8 | $9,508 | 34.9% | 2 | Dec 31 | Jan 15 | THINKFilm | false |
| 37 | Dark Streets | - | - | - | $16,815 | 18 | $10,958 | 65.2% | 18 | Dec 12 | Dec 18 | The Samuel Goldwyn Company | false |
| 38 | A Good Day to Be Black & Sexy | - | - | - | $8,629 | 1 | $6,141 | 71.2% | 1 | Dec 5 | Dec 11 | Magnolia Pictures | false |
| 39 | Where God Left His Shoes | - | - | - | $3,911 | 2 | $2,918 | 74.6% | 2 | Dec 12 | Dec 21 | IFC Films | false |
