| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Natale a Rio | - | - | - | $26,867,922 | 598 | $36,125,993 | Dec 19 | Filmauro | false |
| 2 | Madagascar: Escape 2 Africa | - | - | - | $25,952,344 | 583 | $34,915,869 | Dec 19 | Universal Pictures International (UPI) | false |
| 3 | Il cosmo sul comò | - | - | - | $14,695,553 | 485 | $19,285,300 | Dec 19 | Medusa Distribuzione | false |
| 4 | Changeling | - | - | - | $6,004,714 | 299 | $6,693,283 | Nov 14 | Universal Pictures International (UPI) | false |
| 5 | The Day the Earth Stood Still | - | - | - | $5,816,547 | 448 | $6,037,792 | Dec 12 | 20th Century Fox International | false |
| 6 | Nights in Rodanthe | - | - | - | $5,715,282 | 316 | $8,805,990 | Dec 19 | Warner Bros. | false |
| 7 | Bolt | - | - | - | $4,881,815 | 467 | $7,073,495 | Nov 28 | Walt Disney Pictures | false |
| 8 | Twilight | - | - | - | $4,480,835 | 551 | $14,410,854 | Nov 21 | Eagle Pictures | false |
| 9 | As God Commands | - | - | - | $4,012,062 | 261 | $4,496,101 | Dec 12 | 01 Distribution | false |
| 10 | Saw V | - | - | - | $3,319,993 | 272 | $3,319,993 | Dec 5 | 01 Distribution | false |
| 11 | Body of Lies | - | - | - | $2,783,880 | 357 | $6,005,344 | Nov 21 | Warner Bros. | false |
| 12 | Just a Father | - | - | - | $2,300,611 | 214 | $3,065,931 | Nov 28 | Warner Bros. | false |
| 13 | Slumdog Millionaire | - | - | - | $2,044,799 | 160 | $9,341,549 | Dec 5 | Lucky Red | false |
| 14 | La fidanzata di papà | - | - | - | $1,831,464 | 525 | $9,471,031 | Nov 14 | Medusa Distribuzione | false |
| 15 | The Spirit | - | - | - | $1,674,872 | 227 | $2,896,985 | Dec 26 | Sony Pictures Releasing | false |
| 16 | The Boy in the Striped Pajamas | - | - | - | $1,500,207 | 103 | $3,802,419 | Dec 19 | Walt Disney Pictures | false |
| 17 | Mamma Mia! | - | - | - | $1,382,038 | 400 | $12,919,298 | Oct 3 | United International Pictures | false |
| 18 | City of Ember | - | - | - | $1,377,391 | 139 | $1,618,068 | Dec 19 | Eagle Pictures | false |
| 19 | Never Back Down | - | - | - | $1,350,567 | 169 | $2,084,584 | Nov 28 | Medusa Distribuzione | false |
| 20 | The Duchess | - | - | - | $1,349,717 | 202 | $2,901,441 | Dec 24 | BIM Distribuzione | false |
| 21 | WALL·E | - | - | - | $1,258,637 | 592 | $12,210,993 | Oct 17 | Walt Disney Pictures | false |
| 22 | High School Musical 3: Senior Year | - | - | - | $1,175,793 | 493 | $12,738,501 | Oct 31 | Walt Disney Pictures | false |
| 23 | Max Payne | - | - | - | $1,067,440 | 226 | $1,849,465 | Nov 28 | 20th Century Fox International | false |
| 24 | I'll Be Back to Living Alone | - | - | - | $1,059,633 | 201 | $1,059,633 | Dec 5 | Eagle Pictures | false |
| 25 | Happy-Go-Lucky | - | - | - | $956,178 | 75 | $1,214,552 | Dec 5 | Mikado Film | false |
| 26 | The Visitor | - | - | - | $917,964 | 57 | $2,194,531 | Dec 5 | Bolero Film | false |
| 27 | Vicky Cristina Barcelona | - | - | - | $818,476 | 383 | $8,124,300 | Oct 17 | Medusa Distribuzione | false |
| 28 | Burn After Reading | - | - | - | $794,381 | 421 | $8,734,151 | Sep 19 | Medusa Distribuzione | false |
| 29 | Passengers | - | - | - | $779,722 | 103 | $758,564 | Dec 5 | Moviemax | false |
| 30 | We Can Do That | - | - | - | $674,689 | 98 | $2,610,996 | Oct 31 | Warner Bros. | false |
| 31 | Lemon Tree | - | - | - | $442,975 | 47 | $1,471,720 | Dec 12 | Teodora Film | false |
| 32 | The Class | - | - | - | $343,102 | 108 | $2,223,910 | Oct 10 | Mikado Film | false |
| 33 | Ti stramo: Ho voglia di un'ultima notte da manuale prima di tre baci sopra il cielo | - | - | - | $334,920 | 105 | $606,209 | Nov 28 | Mikado Film | false |
| 34 | The Orphanage | - | - | - | $278,573 | 201 | $2,036,551 | Nov 14 | Lucky Red | false |
| 35 | Galantuomini | - | - | - | $261,813 | 91 | $734,720 | Nov 21 | 01 Distribution | false |
| 36 | Quantum of Solace | - | - | - | $261,325 | 491 | $9,174,615 | Nov 7 | Sony Pictures Releasing | false |
| 37 | Stella | - | - | - | $243,050 | 19 | $491,218 | Dec 5 | Sacher Distribuzione | false |
| 38 | A Christmas Tale | - | - | - | $221,282 | 39 | $232,740 | Dec 5 | BIM Distribuzione | false |
| 39 | Welcome to the Sticks | - | - | - | $220,668 | 325 | $4,245,593 | Oct 31 | Medusa Distribuzione | false |
| 40 | The Burning Plain | - | - | - | $218,843 | 216 | $1,821,499 | Nov 7 | Medusa Distribuzione | false |
| 41 | Death Race | - | - | - | $208,393 | 100 | $418,559 | Nov 28 | Universal Pictures International (UPI) | false |
| 42 | Mid-August Lunch | - | - | - | $187,972 | 116 | $3,083,179 | Sep 3 | Fandango | false |
| 43 | The Man Who Loves | - | - | - | $126,498 | 184 | $1,997,433 | Oct 24 | Medusa Distribuzione | false |
| 44 | Rachel Getting Married | - | - | - | $108,532 | 20 | $288,409 | Nov 21 | Sony Pictures Releasing | false |
| 45 | Comme les autres | - | - | - | $103,081 | 17 | $194,742 | Dec 19 | Archibald | false |
| 46 | Palermo Shooting | - | - | - | $97,659 | 40 | $163,763 | Nov 28 | BIM Distribuzione | false |
| 47 | Io non ci casco | - | - | - | $91,587 | 68 | $91,587 | Dec 5 | Medusa Distribuzione | false |
| 48 | The Past Is a Foreign Land | - | - | - | $70,903 | 179 | $965,171 | Oct 31 | 01 Distribution | false |
| 49 | The House Bunny | - | - | - | $52,446 | 35 | $52,446 | Dec 5 | Sony Pictures Releasing | false |
| 50 | The Early Bird Catches the Worm | - | - | - | $44,764 | 253 | $1,550,893 | Feb 29 | Medusa Distribuzione | false |
| 51 | Someone to Run With | - | - | - | $38,741 | 55 | $138,817 | Nov 21 | Medusa Distribuzione | false |
| 52 | The Duchess of Langeais | - | - | - | $30,777 | 17 | $201,487 | Jul 13 | Mikado Film | false |
| 53 | Ex Drummer | - | - | - | $25,198 | 7 | $83,700 | Oct 3 | L'Altrofilm | false |
| 54 | Márió, a varázsló | - | - | - | $25,137 | 12 | $238,776 | Nov 28 | L'Altrofilm | false |
| 55 | W. | - | - | - | $15,520 | 3 | $28,684 | Dec 18 | - | false |
| 56 | Gomorrah | - | - | - | $12,750 | 441 | $17,665,830 | May 16 | 01 Distribution | false |
| 57 | Giovanna's Father | - | - | - | $9,897 | 357 | $4,846,636 | Sep 12 | Medusa Distribuzione | false |
| 58 | Chromophobia 2007 Re-release | - | - | - | $3,978 | 6 | $3,978 | Dec 12 | Medusa Distribuzione | false |
| 59 | Pineapple Express | - | - | - | $3,948 | 11 | $15,084 | Nov 28 | Sony Pictures Releasing | false |
| 60 | Rumore bianco | - | - | - | $3,912 | 3 | $11,163 | Nov 28 | - | false |
| 61 | Trick or Treaters | - | - | - | $3,757 | 74 | $124,488 | Nov 7 | BIM Distribuzione | false |
| 62 | Diari | - | - | - | $3,730 | 2 | $3,730 | Dec 5 | - | false |
| 63 | Un attimo sospesi | - | - | - | $3,588 | 3 | $3,588 | Dec 5 | - | false |
| 64 | Ho ammazzato Berlusconi | - | - | - | $3,581 | 4 | $77,794 | Jun 20 | Independent Films | false |
| 65 | Stare fuori | - | - | - | $3,392 | 4 | $3,392 | Dec 12 | A.B. Film | false |
| 66 | Amore che vieni, amore che vai | - | - | - | $2,390 | 58 | $112,934 | Nov 14 | Istituto Luce | false |
| 67 | Paris | - | - | - | $2,207 | 65 | $695,130 | Sep 26 | BIM Distribuzione | false |
| 68 | Awake | - | - | - | $2,128 | 139 | $924,096 | Nov 14 | Eagle Pictures | false |
| 69 | Machan | - | - | - | $1,819 | 48 | $222,580 | Sep 12 | Mikado Film | false |
| 70 | Tropic Thunder | - | - | - | $1,664 | 297 | $4,624,397 | Oct 24 | Universal Pictures International (UPI) | false |
| 71 | Noah's Ark | - | - | - | $1,656 | 233 | $1,056,897 | Oct 3 | Eagle Pictures | false |
| 72 | The Pursuit of Happyness | - | - | - | $1,589 | 441 | $21,309,984 | Jan 12 | Medusa Distribuzione | false |
| 73 | Italian Dream | - | - | - | $1,577 | 7 | $17,052 | Jun 27 | Lucky Red | false |
| 74 | Donkey Xote | - | - | - | $1,487 | 69 | $70,295 | Oct 31 | - | false |
| 75 | One Day in a Life | - | - | - | $1,462 | 12 | $428,775 | Nov 7 | Ripley's Film | false |
| 76 | Control | - | - | - | $1,345 | 10 | $99,924 | Oct 24 | Metacinema | false |
| 77 | Be Kind Rewind | - | - | - | $1,316 | 95 | $220,443 | May 23 | BIM Distribuzione | false |
| 78 | The Chronicles of Narnia: Prince Caspian | - | - | - | $1,293 | 601 | $10,800,873 | Aug 14 | Walt Disney Pictures | false |
| 79 | Birdwatchers | - | - | - | $1,235 | 56 | $482,815 | Sep 2 | 01 Distribution | false |
