| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Bee Movie | - | - | - | $564,780 | 57 | $673,669 | Dec 6 | United International Pictures | false |
| 2 | The Golden Compass | - | - | - | $497,097 | 50 | $849,398 | Dec 13 | Warner Bros. | false |
| 3 | Enchanted | - | - | - | $492,412 | 40 | $1,426,461 | Dec 13 | Walt Disney Pictures | false |
| 4 | Beowulf | - | - | - | $394,655 | 37 | $675,440 | Nov 22 | Warner Bros. | false |
| 5 | Che Kopete: La película | - | - | - | $254,596 | 38 | $854,243 | Nov 15 | Los Filmes de la Arcadia | false |
| 6 | Saw IV | - | - | - | $235,944 | 27 | $286,824 | Dec 6 | Walt Disney Pictures | false |
| 7 | Alvin and the Chipmunks | - | - | - | $217,450 | 35 | $791,700 | Dec 20 | 20th Century Fox International | false |
| 8 | The Heartbreak Kid | - | - | - | $212,881 | 28 | $481,654 | Dec 20 | United International Pictures | false |
| 9 | National Treasure: Book of Secrets | - | - | - | $163,932 | 43 | $1,033,173 | Dec 27 | Walt Disney Pictures | false |
| 10 | Lions for Lambs | - | - | - | $137,109 | 24 | $1,377,354 | Nov 15 | 20th Century Fox International | false |
| 11 | Michael Clayton | - | - | - | $108,956 | 15 | $189,470 | Dec 6 | Bazuca Films | false |
| 12 | The Bourne Ultimatum | - | - | - | $83,698 | 30 | $335,991 | Oct 25 | United International Pictures | false |
| 13 | Resident Evil: Extinction | - | - | - | $79,105 | 25 | $390,108 | Oct 31 | Sony Pictures Releasing | false |
| 14 | I Now Pronounce You Chuck & Larry | - | - | - | $74,252 | 26 | $154,650 | Nov 22 | United International Pictures | false |
| 15 | Knocked Up | - | - | - | $64,689 | 24 | $132,254 | Nov 15 | United International Pictures | false |
| 16 | Underdog | - | - | - | $63,439 | 29 | $506,231 | Oct 25 | Walt Disney Pictures | false |
| 17 | 1408 | - | - | - | $50,635 | 20 | $203,975 | Dec 27 | United International Pictures | false |
| 18 | Pulentos, la película | - | - | - | $45,610 | 38 | $145,009 | Dec 27 | Bazuca Films | false |
| 19 | Normal con alas | - | - | - | $26,408 | 15 | $52,171 | Nov 22 | - | false |
| 20 | Next | - | - | - | $25,323 | 18 | $110,075 | Nov 8 | United International Pictures | false |
| 21 | Copying Beethoven | - | - | - | $20,402 | 7 | $20,402 | Nov 29 | Transeuropa | false |
| 22 | The Assassination of Jesse James by the Coward Robert Ford | - | - | - | $20,145 | 10 | $55,512 | Dec 27 | Warner Bros. | false |
| 23 | Premonition | - | - | - | $19,990 | 25 | $275,246 | Oct 11 | Bazuca Films | false |
| 24 | The Seeker: The Dark Is Rising | - | - | - | $18,275 | 29 | $200,218 | Nov 1 | 20th Century Fox International | false |
| 25 | Orchestra Seats | - | - | - | $18,065 | 7 | $72,103 | Nov 8 | Transeuropa | false |
| 26 | Saint Ange 2006 Re-release | - | - | - | $16,459 | 9 | $129,826 | Oct 25 | Bazuca Films | false |
| 27 | Remember Me, My Love 2007 Re-release | - | - | - | $15,842 | 5 | $15,842 | Nov 29 | CDI Films | false |
| 28 | Inland Empire | - | - | - | $15,059 | 2 | $15,059 | Nov 29 | - | false |
| 29 | The Invasion | - | - | - | $13,542 | 17 | $65,354 | Nov 15 | Warner Bros. | false |
| 30 | The Host | - | - | - | $8,174 | 3 | $8,174 | Nov 29 | - | false |
| 31 | Seraphim Falls | - | - | - | $6,784 | 12 | $6,784 | Dec 13 | - | false |
| 32 | Sicko | - | - | - | $4,399 | 3 | $4,399 | Dec 13 | Transeuropa | false |
| 33 | Time | - | - | - | $2,546 | 5 | $39,206 | Nov 1 | Bazuca Films | false |
| 34 | Who Says It's Easy? | - | - | - | $1,584 | 5 | $3,169 | Nov 22 | Quality Films | false |
| 35 | The Year My Parents Went on Vacation | - | - | - | $1,578 | 1 | $1,578 | Nov 29 | Walt Disney Pictures | false |
| 36 | La señal | - | - | - | $1,291 | 4 | $6,221 | Nov 22 | Walt Disney Pictures | false |
| 37 | Rush Hour 3 | - | - | - | $531 | 30 | $208,762 | Oct 18 | Warner Bros. | false |
| 38 | Infamous | - | - | - | $524 | 8 | $40,341 | Oct 25 | - | false |
| 39 | Shoot 'Em Up | - | - | - | $453 | 10 | $46,065 | Nov 8 | Warner Bros. | false |
| 40 | Shutter | - | - | - | $416 | 11 | $67,570 | Oct 4 | Transeuropa | false |
| 41 | Calle Santa Fe | - | - | - | $328 | 1 | $10,669 | Nov 8 | MC Film Dagitim | false |
| 42 | The Dark | - | - | - | $265 | 8 | $120,989 | Aug 23 | Bazuca Films | false |
| 43 | Radio Corazón | - | - | - | $169 | 40 | $1,941,625 | Oct 4 | Bazuca Films | false |
| 44 | Flyboys | - | - | - | $144 | 16 | $12,715 | Nov 15 | - | false |
| 45 | Evan Almighty | - | - | - | $141 | 38 | $395,196 | Sep 27 | United International Pictures | false |
| 46 | Because I Said So | - | - | - | $127 | 8 | $64,075 | Oct 18 | Transeuropa | false |
| 47 | Stardust | - | - | - | $85 | 30 | $193,638 | Oct 11 | United International Pictures | false |
| 48 | Life Kills Me | - | - | - | $55 | 2 | $32,643 | Nov 1 | Bazuca Films | false |
| 49 | The Sugar Curtain | - | - | - | $53 | 1 | $1,622 | Nov 15 | Four Films | false |
| 50 | Running Scared | - | - | - | $28 | 8 | $7,578 | Sep 27 | Bazuca Films | false |
