| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Inception | - | - | - | $3,156,314 | 119 | $7,439,087 | Jul 29 | Warner Bros. | false |
| 2 | Igualita a mí | - | - | - | $1,889,933 | 104 | $3,539,668 | Aug 12 | Walt Disney Pictures | false |
| 3 | The Last Airbender | - | - | - | $1,838,637 | 115 | $2,760,838 | Aug 12 | Paramount Pictures International | false |
| 4 | Despicable Me | - | - | - | $1,451,816 | 146 | $2,878,027 | Jul 29 | Universal Pictures International (UPI) | false |
| 5 | Shrek Forever After | - | - | - | $1,240,039 | 183 | $13,808,538 | Jul 8 | Paramount Pictures International | false |
| 6 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $728,336 | 112 | $1,415,974 | Aug 19 | Warner Bros. | false |
| 7 | The Sorcerer's Apprentice | - | - | - | $643,251 | 87 | $3,129,367 | Jul 15 | Walt Disney Pictures | false |
| 8 | Toy Story 3 | - | - | - | $572,642 | 177 | $16,026,307 | Jun 17 | Walt Disney Pictures | false |
| 9 | Pájaros volando | - | - | - | $405,696 | 44 | $450,678 | Aug 5 | Primer Plano Film Group | false |
| 10 | Predators | - | - | - | $394,143 | 52 | $553,936 | Aug 12 | 20th Century Fox International | false |
| 11 | Vincere | - | - | - | $283,595 | 20 | $343,189 | Aug 5 | CDI Films | false |
| 12 | Salt | - | - | - | $240,165 | 59 | $562,778 | Aug 26 | Sony Pictures Releasing | false |
| 13 | Chloe | - | - | - | $127,977 | 19 | $160,700 | Aug 12 | Alfa Films | false |
| 14 | Grown Ups | - | - | - | $115,877 | 45 | $565,029 | Jul 22 | Sony Pictures Releasing | false |
| 15 | Hot Tub Time Machine | - | - | - | $107,965 | 27 | $118,847 | Aug 5 | - | false |
| 16 | Knight and Day Original Release | - | - | - | $103,290 | 75 | $1,000,206 | Jul 15 | 20th Century Fox International | false |
| 17 | The Twilight Saga: Eclipse | - | - | - | $93,440 | 120 | $4,373,158 | Jul 1 | Alfa Films | false |
| 18 | Solitary Man | - | - | - | $74,268 | 21 | $227,969 | Aug 26 | Distribution Company | false |
| 19 | London River 2010 Re-release | - | - | - | $66,438 | 17 | $77,714 | Aug 19 | Primer Plano Film Group | false |
| 20 | Five Minutes of Heaven | - | - | - | $50,154 | 20 | $51,698 | Aug 5 | Distribution Company | false |
| 21 | The Invisible Eye | - | - | - | $48,621 | 12 | $76,158 | Aug 19 | Distribution Company | false |
| 22 | Carriers | - | - | - | $35,513 | 26 | $184,432 | Jul 22 | Distribution Company | false |
| 23 | I Hate Valentine's Day | - | - | - | $28,597 | 9 | $52,685 | Jul 29 | Impacto Cine | false |
| 24 | Little Girl | - | - | - | $25,686 | 8 | $118,507 | Jul 8 | - | false |
| 25 | The Boys Are Back | - | - | - | $22,694 | 17 | $40,985 | Aug 26 | Alfa Films | false |
| 26 | Leaving | - | - | - | $21,337 | 14 | $123,433 | Jul 22 | Alfa Films | false |
| 27 | Letters to Juliet | - | - | - | $20,138 | 17 | $398,187 | Jun 10 | Alfa Films | false |
| 28 | Silent Light 2010 Re-release | - | - | - | $13,046 | 4 | $25,956 | Aug 26 | Impacto Cine | false |
| 29 | Miss Tacuarembó | - | - | - | $11,568 | 58 | $159,421 | Jul 15 | - | false |
| 30 | Interview 2010 Re-release | - | - | - | $10,674 | 4 | $13,258 | Aug 12 | - | false |
| 31 | The Ghost Writer | - | - | - | $9,173 | 42 | $789,829 | May 13 | Alfa Films | false |
| 32 | Chéri | - | - | - | $9,029 | 11 | $127,587 | Jul 8 | CDI Films | false |
| 33 | Hansel and Gretel 2010 Re-release | - | - | - | $8,482 | 8 | $11,511 | Aug 26 | Impacto Cine | false |
| 34 | Marmaduke | - | - | - | $4,684 | 31 | $201,229 | May 27 | 20th Century Fox International | false |
| 35 | The Karate Kid | - | - | - | $4,596 | 80 | $917,488 | Jun 24 | Sony Pictures Releasing | false |
| 36 | Jungle Tales | - | - | - | $4,220 | 47 | $76,857 | Jul 22 | Primer Plano Film Group | false |
| 37 | The A-Team | - | - | - | $4,147 | 60 | $325,161 | Jun 24 | 20th Century Fox International | false |
| 38 | Tricks | - | - | - | $3,535 | 4 | $4,866 | Aug 12 | Primer Plano Film Group | false |
| 39 | Police, Adjective | - | - | - | $3,362 | 6 | $24,564 | Jul 22 | Primer Plano Film Group | false |
| 40 | The Road | - | - | - | $3,098 | 33 | $327,895 | Jun 24 | Distribution Company | false |
| 41 | Sex and the City 2 | - | - | - | $2,630 | 82 | $1,188,295 | Jun 3 | Warner Bros. | false |
| 42 | Oceans | - | - | - | $1,724 | 21 | $87,919 | Jul 1 | Distribution Company | false |
| 43 | The White Ribbon | - | - | - | $1,561 | 15 | $180,975 | Apr 22 | - | false |
| 44 | South of the Border | - | - | - | $566 | 4 | $65,940 | Jun 3 | - | false |
| 45 | Prince of Persia: The Sands of Time | - | - | - | $362 | 99 | $3,101,060 | May 27 | Walt Disney Pictures | false |
