| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | G-Force | - | - | - | $9,501,543 | 699 | $9,775,301 | Jul 31 | Walt Disney Pictures | false |
| 2 | Terminator Salvation | - | - | - | $7,172,319 | 771 | $7,475,980 | Jul 31 | Sony Pictures Releasing | false |
| 3 | G.I. Joe: The Rise of Cobra | - | - | - | $7,017,958 | 750 | $7,228,645 | Aug 7 | Paramount Pictures International | false |
| 4 | The Hangover | - | - | - | $4,889,339 | 401 | $7,191,582 | Aug 14 | Warner Bros. | false |
| 5 | Ice Age: Dawn of the Dinosaurs | - | - | - | $3,959,080 | 970 | $39,389,248 | Jul 3 | 20th Century Fox International | false |
| 6 | Harry Potter and the Half-Blood Prince | - | - | - | $3,570,571 | 1,009 | $21,185,512 | Jul 16 | Warner Bros. | false |
| 7 | Land of the Lost | - | - | - | $1,714,023 | 257 | $2,888,757 | Aug 14 | Universal Pictures International (UPI) | false |
| 8 | Drag Me to Hell | - | - | - | $1,626,267 | 318 | $3,131,329 | Aug 21 | Universal Pictures International (UPI) | false |
| 9 | The Uninvited | - | - | - | $1,422,334 | 249 | $2,612,910 | Jul 24 | Paramount Pictures International | false |
| 10 | My Sister's Keeper | - | - | - | $1,314,109 | 199 | $3,698,528 | Jun 26 | Warner Bros. | false |
| 11 | Shorts | - | - | - | $1,308,300 | 299 | $1,459,722 | Aug 7 | Warner Bros. | false |
| 12 | The Time Traveler's Wife | - | - | - | $1,183,246 | 262 | $2,345,730 | Aug 21 | Gussi Films | false |
| 13 | Crossing Over | - | - | - | $751,221 | 192 | $1,289,318 | Jul 24 | - | false |
| 14 | Imagine That | - | - | - | $618,053 | 273 | $1,048,584 | Aug 21 | Paramount Pictures International | false |
| 15 | Walking Vengeance | - | - | - | $578,271 | 265 | $807,908 | Aug 21 | Videocine | false |
| 16 | Aliens in the Attic | - | - | - | $545,562 | 300 | $2,185,351 | Aug 28 | 20th Century Fox International | false |
| 17 | Recién Cazado | - | - | - | $447,921 | 200 | $2,688,461 | Aug 28 | Warner Bros. | false |
| 18 | Enemigos íntimos | - | - | - | $413,634 | 112 | $564,867 | Aug 7 | - | false |
| 19 | El ratón Pérez 2 | - | - | - | $367,348 | 200 | $563,620 | Aug 14 | Walt Disney Pictures | false |
| 20 | Public Enemies | - | - | - | $359,957 | 398 | $5,318,012 | Jul 3 | Universal Pictures International (UPI) | false |
| 21 | All Inclusive | - | - | - | $346,714 | 250 | $1,680,062 | Jul 10 | Universal Pictures International (UPI) | false |
| 22 | The Code | - | - | - | $342,468 | 201 | $1,142,014 | Jul 10 | Gussi Films | false |
| 23 | Transformers: Revenge of the Fallen | - | - | - | $253,870 | 908 | $18,895,683 | Jun 23 | Paramount Pictures International | false |
| 24 | Defiance | - | - | - | $247,627 | 178 | $1,253,622 | Aug 28 | - | false |
| 25 | How to Lose Friends & Alienate People | - | - | - | $206,135 | 99 | $465,825 | Jul 24 | - | false |
| 26 | Smother | - | - | - | $181,243 | 80 | $518,976 | Jul 10 | Videocine | false |
| 27 | Full of It 2009 Re-release | - | - | - | $174,804 | 148 | $372,791 | Aug 14 | Videocine | false |
| 28 | The Proposal | - | - | - | $149,787 | 436 | $6,665,637 | Jun 19 | Walt Disney Pictures | false |
| 29 | 17 Again | - | - | - | $86,080 | 310 | $2,623,446 | Jun 19 | Gussi Films | false |
| 30 | Fugitive Pieces | - | - | - | $78,100 | 14 | $96,217 | Aug 7 | - | false |
| 31 | El Estudiante | - | - | - | $67,702 | 133 | $3,041,991 | Aug 14 | - | false |
| 32 | 2:37 2009 Re-release | - | - | - | $55,572 | 35 | $89,302 | Aug 7 | Gussi Films | false |
| 33 | Happy-Go-Lucky | - | - | - | $48,392 | 11 | $160,032 | Jun 26 | - | false |
| 34 | It's Alive | - | - | - | $46,224 | 60 | $224,474 | Jul 17 | Gussi Films | false |
| 35 | Reprise | - | - | - | $38,259 | 12 | $91,382 | Jul 24 | - | false |
| 36 | The Fox and the Child | - | - | - | $25,455 | 59 | $25,455 | Aug 21 | - | false |
| 37 | Gomorrah | - | - | - | $25,226 | 9 | $102,605 | Jul 10 | - | false |
| 38 | Waltz with Bashir | - | - | - | $8,593 | 10 | $45,711 | Jul 17 | - | false |
| 39 | Rachel Getting Married | - | - | - | $7,180 | 10 | $163,954 | Mar 20 | Sony Pictures Releasing | false |
| 40 | Import Export | - | - | - | $6,910 | 2 | $9,150 | Aug 7 | - | false |
| 41 | I'm Gonna Explode | - | - | - | $6,575 | 40 | $66,021 | May 16 | Videocine | false |
| 42 | Religulous | - | - | - | $5,905 | 26 | $37,049 | Jul 10 | - | false |
| 43 | Up | - | - | - | $5,060 | 799 | $14,192,640 | Jun 5 | Walt Disney Pictures | false |
| 44 | Three Monkeys | - | - | - | $3,763 | 4 | $50,967 | Jun 12 | - | false |
| 45 | Blame it on Fidel | - | - | - | $3,747 | 9 | $46,063 | Jun 26 | - | false |
| 46 | Night at the Museum: Battle of the Smithsonian | - | - | - | $1,469 | 812 | $10,088,016 | Jun 12 | 20th Century Fox International | false |
