| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Ice Age: Dawn of the Dinosaurs | - | - | - | $9,779,301 | 812 | $43,860,019 | Aug 28 | 20th Century Fox International | false |
| 2 | Harry Potter and the Half-Blood Prince | - | - | - | $4,278,802 | 890 | $26,965,672 | Jul 15 | Warner Bros. | false |
| 3 | Sex Drive | - | - | - | $1,478,450 | 151 | $1,951,363 | Aug 14 | Eagle Pictures | false |
| 4 | The Hangover | - | - | - | $1,237,919 | 292 | $5,950,032 | Jun 19 | Warner Bros. | false |
| 5 | The Haunting in Connecticut | - | - | - | $1,216,957 | 198 | $1,900,389 | Aug 21 | Lucky Red | false |
| 6 | Aliens in the Attic | - | - | - | $934,216 | 210 | $934,216 | Aug 14 | 20th Century Fox International | false |
| 7 | S. Darko | - | - | - | $837,192 | 214 | $993,083 | Aug 21 | - | false |
| 8 | Ghosts of Girlfriends Past | - | - | - | $830,091 | 216 | $2,823,783 | Jul 3 | Warner Bros. | false |
| 9 | Angels & Demons | - | - | - | $694,907 | 818 | $26,775,811 | May 13 | Sony Pictures Releasing | false |
| 10 | Transformers: Revenge of the Fallen | - | - | - | $692,965 | 578 | $11,685,751 | Jun 26 | United International Pictures | false |
| 11 | Coraline | - | - | - | $388,356 | 205 | $4,957,811 | Jun 19 | United International Pictures | false |
| 12 | Outlander | - | - | - | $299,319 | 197 | $1,662,491 | Jul 3 | Eagle Pictures | false |
| 13 | The Girl with the Dragon Tattoo | - | - | - | $281,547 | 437 | $5,295,520 | May 29 | BIM Distribuzione | false |
| 14 | The Boat That Rocked | - | - | - | $260,710 | 99 | $1,383,446 | Jun 12 | United International Pictures | false |
| 15 | Journey to the Center of the Earth | - | - | - | $250,848 | 276 | $11,724,131 | Jan 16 | 01 Distribution | false |
| 16 | Chéri | - | - | - | $233,124 | 112 | $917,932 | Aug 28 | 01 Distribution | false |
| 17 | Shorts | - | - | - | $216,205 | 141 | $216,205 | Aug 21 | Warner Bros. | false |
| 18 | Un'estate ai Caraibi | - | - | - | $185,860 | 545 | $5,311,857 | Jun 12 | Medusa Distribuzione | false |
| 19 | Smile | - | - | - | $119,718 | - | $260,150 | Aug 28 | - | false |
| 20 | The Wackness | - | - | - | $100,333 | 92 | $275,494 | Aug 28 | Fandango | false |
| 21 | I Love You, Man | - | - | - | $86,204 | 49 | $86,204 | Aug 21 | United International Pictures | false |
| 22 | Imagine That | - | - | - | $86,182 | 12 | $86,182 | Jul 31 | United International Pictures | false |
| 23 | Killshot | - | - | - | $75,474 | 12 | $75,474 | Jul 31 | 01 Distribution | false |
| 24 | I Know Who Killed Me | - | - | - | $74,500 | 22 | $152,633 | Sep 5 | Moviemax | false |
| 25 | The Longshots | - | - | - | $73,530 | 9 | $181,594 | Aug 28 | 01 Distribution | false |
| 26 | School for Scoundrels 2009 Re-release | - | - | - | $73,157 | 10 | $182,709 | Aug 28 | 01 Distribution | false |
| 27 | Night at the Museum: Battle of the Smithsonian | - | - | - | $65,074 | 518 | $9,988,389 | May 22 | 20th Century Fox International | false |
| 28 | Slumdog Millionaire | - | - | - | $62,676 | 160 | $9,341,549 | Dec 5 | Lucky Red | false |
| 29 | Flash of Genius | - | - | - | $60,891 | 52 | $60,891 | Aug 7 | United International Pictures | false |
| 30 | Ultimate Heist | - | - | - | $53,967 | 3 | $53,967 | Jul 31 | Medusa Distribuzione | false |
| 31 | State of Play | - | - | - | $49,449 | 301 | $3,559,324 | Apr 30 | United International Pictures | false |
| 32 | Towelhead | - | - | - | $46,239 | 20 | $103,106 | Jul 17 | - | false |
| 33 | Vincere | - | - | - | $45,006 | 302 | $2,991,766 | May 20 | 01 Distribution | false |
| 34 | Baby Mama | - | - | - | $43,126 | 102 | $117,506 | Jul 24 | United International Pictures | false |
| 35 | My Best Friend's Girl | - | - | - | $41,916 | 150 | $1,537,633 | Jun 19 | Eagle Pictures | false |
| 36 | Notorious | - | - | - | $41,881 | 103 | $209,043 | Jul 17 | 20th Century Fox International | false |
| 37 | Coco Before Chanel | - | - | - | $36,756 | 164 | $1,792,873 | May 29 | Warner Bros. | false |
| 38 | Monsters vs. Aliens | - | - | - | $36,748 | 496 | $10,546,331 | Apr 3 | United International Pictures | false |
| 39 | Obsessed | - | - | - | $34,783 | 12 | $83,546 | Jul 17 | Sony Pictures Releasing | false |
| 40 | The Friends at the Margherita Cafe | - | - | - | $31,835 | 265 | $4,326,733 | Apr 3 | 01 Distribution | false |
| 41 | Las 13 rosas 2009 Re-release | - | - | - | $29,222 | 43 | $29,222 | Aug 28 | - | false |
| 42 | Piede di dio | - | - | - | $27,266 | - | $70,046 | Aug 28 | - | false |
| 43 | Gran Torino | - | - | - | $26,738 | 332 | $12,993,866 | Mar 13 | Warner Bros. | false |
| 44 | My Bloody Valentine | - | - | - | $26,496 | 278 | $8,725,914 | May 8 | Medusa Distribuzione | false |
| 45 | 12 Rounds | - | - | - | $21,424 | 10 | $21,424 | Jul 3 | 20th Century Fox International | false |
| 46 | Soul Men | - | - | - | $20,858 | 10 | $219,923 | Jul 17 | 01 Distribution | false |
| 47 | We Can Do That | - | - | - | $20,574 | 98 | $2,610,996 | Oct 31 | Warner Bros. | false |
| 48 | Ghost Town | - | - | - | $20,077 | 50 | $96,482 | Jul 17 | United International Pictures | false |
| 49 | The Visitor | - | - | - | $16,681 | 57 | $2,194,531 | Dec 5 | Bolero Film | false |
| 50 | Two Lovers | - | - | - | $16,149 | 108 | $1,339,026 | Mar 27 | BIM Distribuzione | false |
| 51 | Adventureland | - | - | - | $16,038 | 15 | $31,944 | Jul 10 | Walt Disney Pictures | false |
| 52 | The Nightmare Before Christmas 2008 3D Release | - | - | - | $14,856 | 9 | $144,321 | Nov 30 | Walt Disney Pictures | false |
| 53 | Lake Tahoe | - | - | - | $14,354 | 13 | $14,354 | Aug 28 | - | false |
| 54 | Bolt | - | - | - | $14,255 | 467 | $7,073,495 | Nov 28 | Walt Disney Pictures | false |
| 55 | The Reader | - | - | - | $10,754 | 161 | $3,645,596 | Feb 20 | 01 Distribution | false |
| 56 | Different from Whom | - | - | - | $9,048 | 364 | $4,602,897 | Mar 20 | United International Pictures | false |
| 57 | Mid-August Lunch | - | - | - | $7,956 | 116 | $3,083,179 | Sep 3 | Fandango | false |
| 58 | Mamma Mia! | - | - | - | $6,821 | 400 | $12,919,298 | Oct 3 | United International Pictures | false |
| 59 | Tutta la vita davanti | - | - | - | $6,716 | 368 | $5,648,340 | Mar 28 | Medusa Distribuzione | false |
| 60 | Louise hires a contract killer | - | - | - | $5,716 | 48 | $803,171 | Apr 3 | Fandango | false |
| 61 | The Wave | - | - | - | $4,946 | 57 | $696,752 | Feb 27 | BIM Distribuzione | false |
| 62 | Ex | - | - | - | $4,743 | 571 | $15,340,865 | Feb 6 | 01 Distribution | false |
| 63 | Brideshead Revisited | - | - | - | $4,451 | 15 | $71,921 | Jun 26 | Walt Disney Pictures | false |
| 64 | The Man Who Loves | - | - | - | $4,432 | 184 | $1,997,433 | Oct 24 | Medusa Distribuzione | false |
| 65 | Easy Virtue | - | - | - | $4,216 | 142 | $3,590,951 | Jan 9 | Eagle Pictures | false |
| 66 | The Curious Case of Benjamin Button | - | - | - | $3,925 | 502 | $15,750,900 | Feb 13 | Warner Bros. | false |
| 67 | Questione di cuore | - | - | - | $3,835 | 264 | $3,919,677 | Apr 17 | 01 Distribution | false |
| 68 | Chef's Special 2009 Re-release | - | - | - | $3,256 | 97 | $514,692 | Apr 24 | - | false |
