| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Proposal | - | - | - | $188,594 | 6 | $229,159 | Jul 29 | Walt Disney Pictures | false |
| 2 | The Girl with the Dragon Tattoo | - | - | - | $174,398 | 4 | $337,563 | Jul 22 | - | false |
| 3 | Public Enemies | - | - | - | $109,709 | 5 | $141,273 | Aug 5 | United International Pictures | false |
| 4 | G-Force | - | - | - | $88,441 | 5 | $121,676 | Aug 7 | Walt Disney Pictures | false |
| 5 | Harry Potter and the Half-Blood Prince | - | - | - | $68,565 | 8 | $326,528 | Jul 15 | Warner Bros. | false |
| 6 | G.I. Joe: The Rise of Cobra | - | - | - | $54,003 | 5 | $75,827 | Aug 12 | United International Pictures | false |
| 7 | Ice Age: Dawn of the Dinosaurs | - | - | - | $49,610 | 14 | $277,222 | Jul 1 | 20th Century Fox International | false |
| 8 | Inglourious Basterds | - | - | - | $46,800 | 5 | $226,081 | Aug 26 | United International Pictures | false |
| 9 | Drag Me to Hell | - | - | - | $40,315 | 3 | $70,994 | Aug 19 | - | false |
| 10 | Up | - | - | - | $39,930 | 10 | $224,274 | Aug 28 | Walt Disney Pictures | false |
| 11 | The Taking of Pelham 123 | - | - | - | $27,187 | 4 | $40,609 | Aug 19 | Sony Pictures Releasing | false |
| 12 | My Sister's Keeper | - | - | - | $22,941 | 3 | $92,493 | Jul 8 | - | false |
| 13 | The Hangover | - | - | - | $15,315 | 6 | $409,414 | Jun 10 | Warner Bros. | false |
| 14 | Fighting | - | - | - | $12,217 | 2 | $23,915 | Jul 22 | United International Pictures | false |
| 15 | The Goods: Live Hard, Sell Hard | - | - | - | $11,979 | 2 | $19,895 | Aug 19 | - | false |
| 16 | Brüno | - | - | - | $11,780 | 6 | $184,024 | Jul 10 | - | false |
| 17 | The Time Traveler's Wife | - | - | - | $10,851 | 2 | $14,593 | Aug 19 | - | false |
| 18 | Crossing Over | - | - | - | $10,067 | 2 | $11,964 | Aug 5 | Sena | false |
| 19 | Funny Games | - | - | - | $9,080 | 1 | $10,930 | Aug 5 | - | false |
| 20 | Transformers: Revenge of the Fallen | - | - | - | $6,263 | 8 | $213,912 | Jun 24 | United International Pictures | false |
| 21 | The Hurt Locker | - | - | - | $5,079 | 2 | $27,130 | Jul 8 | - | false |
| 22 | District 13: Ultimatum | - | - | - | $1,050 | 1 | $6,900 | Jul 17 | - | false |
| 23 | Extreme Movie | - | - | - | $930 | 2 | $2,374 | Jul 29 | - | false |
| 24 | Angels & Demons | - | - | - | $865 | 6 | $287,459 | May 15 | Sony Pictures Releasing | false |
| 25 | Balls Out: Gary the Tennis Coach | - | - | - | $536 | 2 | $10,303 | Jul 15 | - | false |
