| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Angels & Demons | - | - | - | $3,132,272 | 4 | $4,383,490 | May 13 | Sony Pictures Releasing | false |
| 2 | Ice Age: Dawn of the Dinosaurs | - | - | - | $1,459,002 | 106 | $13,999,976 | Jul 1 | 20th Century Fox International | false |
| 3 | The Hangover | - | - | - | $1,071,287 | 77 | $2,744,287 | Jun 24 | Warner Bros. | false |
| 4 | Harry Potter and the Half-Blood Prince | - | - | - | $1,047,112 | 112 | $6,126,878 | Jul 15 | Warner Bros. | false |
| 5 | The Proposal | - | - | - | $919,273 | 55 | $1,462,989 | Jul 30 | Walt Disney Pictures | false |
| 6 | Up | - | - | - | $657,464 | 31 | $1,056,614 | Jul 29 | Walt Disney Pictures | false |
| 7 | Public Enemies | - | - | - | $494,911 | 51 | $1,108,599 | Jul 8 | Universal Pictures International (UPI) | false |
| 8 | G.I. Joe: The Rise of Cobra | - | - | - | $385,859 | 50 | $408,952 | Aug 6 | Universal Pictures International (UPI) | false |
| 9 | My Bloody Valentine | - | - | - | $236,606 | 18 | $236,606 | Aug 13 | - | false |
| 10 | Brüno | - | - | - | $190,167 | 59 | $2,357,912 | Jul 22 | - | false |
| 11 | The Taking of Pelham 123 | - | - | - | $152,963 | 14 | $264,966 | Jul 29 | Sony Pictures Releasing | false |
| 12 | Broken Embraces | - | - | - | $67,440 | 11 | $456,335 | Aug 13 | - | false |
| 13 | Whatever Works | - | - | - | $52,620 | 10 | $122,901 | Aug 12 | - | false |
| 14 | The Hurt Locker | - | - | - | $43,385 | 17 | $43,385 | Aug 13 | - | false |
| 15 | Maria, He Doesn't Like It | - | - | - | $40,351 | 8 | $40,351 | Aug 6 | - | false |
| 16 | Everyone Else | - | - | - | $31,443 | 9 | $247,804 | Jul 2 | - | false |
| 17 | State of Play | - | - | - | $19,400 | 6 | $1,187,691 | Jun 17 | Universal Pictures International (UPI) | false |
| 18 | Looking for Eric | - | - | - | $16,103 | 2 | $161,903 | Jun 10 | - | false |
| 19 | Crank: High Voltage | - | - | - | $15,629 | 8 | $973,773 | Aug 12 | - | false |
| 20 | Bandslam | - | - | - | $15,031 | 8 | $17,980 | Aug 12 | - | false |
| 21 | Sunshine Cleaning | - | - | - | $13,061 | 3 | $76,858 | Aug 5 | - | false |
| 22 | The Girl with the Dragon Tattoo | - | - | - | $12,780 | 3 | $513,726 | May 13 | - | false |
