| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Max Th | Opening | % of Total
| Open Th | Open | Close | Distributor
| Estimated
|
|---|
| 1 | Avengers: Infinity War | - | - | - | $22,837,545 | 976 | $7,384,164 | 32.3% | 976 | Apr 25 | - | Walt Disney Pictures | false |
| 2 | Loro 1 | - | - | - | $4,740,179 | 539 | $1,248,325 | 26.3% | 539 | Apr 26 | - | Universal Pictures International (UPI) | false |
| 3 | Loving Pablo | - | - | - | $4,023,182 | 750 | $1,175,608 | 29.2% | 406 | Apr 19 | - | Notorious Pictures | false |
| 4 | Rampage | - | - | - | $3,300,000 | 430 | $1,547,524 | 46.9% | 430 | Apr 12 | - | Warner Bros. | false |
| 5 | Den of Thieves | - | - | - | $2,714,645 | 367 | $1,148,331 | 42.3% | 367 | Apr 5 | - | Lucky Red | false |
| 6 | Io sono Tempesta | - | - | - | $1,993,225 | 656 | $974,519 | 48.9% | 376 | Apr 12 | - | 01 Distribution | false |
| 7 | Wind River | - | - | - | $1,398,487 | 215 | $447,089 | 32% | 133 | Apr 5 | - | Eagle Pictures | false |
| 8 | A Quiet Place | - | - | - | $1,339,341 | 308 | $489,801 | 36.6% | 280 | Apr 5 | - | Paramount Pictures International | false |
| 9 | Sherlock Gnomes | - | - | - | $920,901 | 351 | $383,884 | 41.7% | 333 | Apr 12 | - | Paramount Pictures International | false |
| 10 | The House by the Sea | - | - | - | $574,986 | 53 | $106,789 | 18.6% | 27 | Apr 12 | - | Parthenos | false |
| 11 | Succede | - | - | - | $546,697 | 306 | $341,091 | 62.4% | 306 | Apr 5 | - | Warner Bros. | false |
| 12 | Tu mi nascondi qualcosa | - | - | - | $527,951 | 228 | $239,567 | 45.4% | 228 | Apr 26 | - | Eagle Pictures | false |
| 13 | Mark Felt: The Man Who Brought Down the White House | - | - | - | $497,559 | 239 | $333,464 | 67% | 239 | Apr 12 | - | Wild Bunch Distribution | false |
| 14 | Ghost Stories | - | - | - | $417,891 | 206 | $228,302 | 54.6% | 206 | Apr 19 | - | Adler Entertainment | false |
| 15 | Molly's Game | - | - | - | $412,962 | 222 | $195,547 | 47.4% | 222 | Apr 19 | - | Rai Cinema International Distribution | false |
| 16 | The Happy Prince | - | - | - | $410,128 | 159 | $257,092 | 62.7% | 159 | Apr 12 | - | - | false |
| 17 | The Young Karl Marx | - | - | - | $394,011 | 67 | $102,363 | 26% | 45 | Apr 5 | - | - | false |
| 18 | As Needed | - | - | - | $389,762 | 172 | $192,165 | 49.3% | 172 | Apr 5 | - | Notorious Pictures | false |
| 19 | Earth: One Amazing Day | - | - | - | $387,952 | 226 | $104,089 | 26.8% | 226 | Apr 19 | - | Koch Media | false |
| 20 | Il tuttofare | - | - | - | $382,926 | 331 | $232,352 | 60.7% | 331 | Apr 19 | - | - | false |
| 21 | La Melodie | - | - | - | $330,955 | 50 | $70,570 | 21.3% | 50 | Apr 26 | - | Officine UBU | false |
| 22 | Let the Sunshine In | - | - | - | $294,348 | 79 | $112,536 | 38.2% | 79 | Apr 19 | - | - | false |
| 23 | Bob & Marys | - | - | - | $273,055 | 186 | $143,346 | 52.5% | 186 | Apr 5 | - | Videa | false |
| 24 | Wajib | - | - | - | $191,398 | 31 | $50,099 | 26.2% | 23 | Apr 26 | - | Satine Film | false |
| 25 | The Mercy | - | - | - | $157,954 | 160 | $102,671 | 65% | 129 | Apr 5 | - | Good Films | false |
| 26 | The Net | - | - | - | $144,991 | 1 | - | - | - | Apr 12 | - | Tucker Film | false |
| 27 | Girls Trip | - | - | - | $87,223 | 105 | $62,076 | 71.2% | 105 | Apr 12 | - | Universal Pictures International (UPI) | false |
| 28 | My Name Is Thomas | - | - | - | $68,623 | 151 | $63,083 | 91.9% | 151 | Apr 19 | - | - | false |
| 29 | Double Lover | - | - | - | $59,248 | 66 | $59,248 | 100% | 66 | Apr 19 | - | Academy 2 | false |
| 30 | Lean on Pete | - | - | - | $52,260 | 50 | $49,716 | 95.1% | 50 | Apr 5 | - | Teodora Film | false |
| 31 | Sugar Baby | - | - | - | $32,955 | 100 | $28,466 | 86.4% | 100 | Apr 26 | - | Koch Media | false |
| 32 | Terra Bruciata! - Scorched Earth! | - | - | - | $28,334 | 1 | - | - | - | Apr 25 | - | - | false |