| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Bounty Hunter | - | - | - | $1,313,033 | 57 | $1,410,328 | Apr 1 | Sony Pictures Releasing | false |
| 2 | How to Train Your Dragon | - | - | - | $1,293,174 | 95 | $553,139 | Mar 26 | United International Pictures | false |
| 3 | Clash of the Titans | - | - | - | $1,112,820 | 85 | $1,378,879 | Apr 16 | Warner Bros. | false |
| 4 | Date Night | - | - | - | $622,601 | 60 | $807,654 | Apr 9 | 20th Century Fox International | false |
| 5 | Tooth Fairy | - | - | - | $602,868 | 64 | $1,519,904 | Mar 19 | 20th Century Fox International | false |
| 6 | Alice in Wonderland | - | - | - | $541,052 | 95 | $3,188,348 | Mar 5 | Walt Disney Pictures | false |
| 7 | Nanny McPhee Returns | - | - | - | $493,517 | 42 | $561,898 | Apr 1 | United International Pictures | false |
| 8 | The Blind Side | - | - | - | $458,554 | 53 | $1,046,568 | Mar 19 | Warner Bros. | false |
| 9 | It's Complicated | - | - | - | $235,816 | 66 | $1,466,267 | Feb 26 | United International Pictures | false |
| 10 | Leap Year | - | - | - | $217,406 | 44 | $281,741 | Apr 16 | United International Pictures | false |
| 11 | The Hurt Locker | - | - | - | $198,206 | 21 | $316,525 | Mar 26 | NuMetro Distribution | false |
| 12 | Shutter Island | - | - | - | $186,520 | 46 | $686,846 | Mar 12 | United International Pictures | false |
| 13 | When in Rome | - | - | - | $175,059 | 30 | $354,116 | Apr 23 | Walt Disney Pictures | false |
| 14 | Jakhalsdans | - | - | - | $165,093 | 88 | $411,116 | Apr 23 | - | false |
| 15 | Hachi: A Dog's Tale | - | - | - | $148,526 | 24 | $181,740 | Apr 16 | Ster-Kinekor Pictures | false |
| 16 | Kick-Ass | - | - | - | $98,319 | 41 | $139,709 | Apr 23 | NuMetro Distribution | false |
| 17 | Armored | - | - | - | $80,923 | 31 | $168,261 | Mar 26 | Sony Pictures Releasing | false |
| 18 | The Last Station 2010 Re-release | - | - | - | $79,253 | 12 | $151,078 | Mar 26 | Ster-Kinekor Pictures | false |
| 19 | The Accidental Husband | - | - | - | $68,196 | 20 | $112,042 | Apr 23 | Ster-Kinekor Pictures | false |
| 20 | The Book of Eli | - | - | - | $62,715 | 60 | $772,044 | Feb 26 | Sony Pictures Releasing | false |
| 21 | Valentine's Day | - | - | - | $48,662 | 67 | $1,583,752 | Feb 12 | NuMetro Distribution | false |
| 22 | Nine | - | - | - | $39,827 | 26 | $195,627 | Mar 12 | Sony Pictures Releasing | false |
| 23 | Fast & Frantic | - | - | - | $39,523 | 25 | $39,523 | Apr 1 | NuMetro Distribution | false |
| 24 | Extraordinary Measures | - | - | - | $38,626 | 16 | $50,208 | Apr 23 | Sony Pictures Releasing | false |
| 25 | Avatar | - | - | - | $37,218 | 100 | $7,417,291 | Dec 18 | 20th Century Fox International | false |
| 26 | The Spy Next Door 2010 Re-release | - | - | - | $29,458 | 50 | $648,495 | Feb 5 | - | false |
| 27 | Outrageous | - | - | - | $26,069 | 22 | $26,069 | Apr 9 | - | false |
| 28 | Away We Go | - | - | - | $22,429 | 10 | $22,429 | Apr 9 | NuMetro Distribution | false |
| 29 | The Descent: Part 2 | - | - | - | $22,056 | 12 | $22,056 | Apr 9 | Ster-Kinekor Pictures | false |
| 30 | An Education | - | - | - | $12,488 | 11 | $195,624 | Jan 29 | United International Pictures | false |
| 31 | Remember Me | - | - | - | $12,189 | 40 | $234,504 | Mar 12 | NuMetro Distribution | false |
| 32 | Saw VI | - | - | - | $9,784 | 20 | $81,182 | Mar 19 | - | false |
| 33 | The Cove | - | - | - | $5,543 | 9 | $5,543 | Apr 1 | - | false |
| 34 | Precious | - | - | - | $3,590 | 17 | $157,428 | Mar 5 | - | false |
| 35 | Quick Gun Murugun: Misadventures of an Indian Cowboy | - | - | - | $2,070 | 5 | $2,070 | Apr 9 | - | false |
| 36 | Up in the Air | - | - | - | $1,777 | 26 | $447,997 | Jan 29 | United International Pictures | false |
| 37 | The Wolfman | - | - | - | $871 | 59 | $535,525 | Feb 12 | - | false |
| 38 | Jozi | - | - | - | $433 | 42 | $106,144 | Feb 26 | United International Pictures | false |
| 39 | The Tournament | - | - | - | $430 | 1 | $814 | Mar 26 | - | false |
