| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Clash of the Titans | - | - | - | $1,754,426 | 93 | $3,010,415 | Apr 16 | Warner Bros. | false |
| 2 | How to Train Your Dragon | - | - | - | $870,343 | 76 | $1,719,199 | Mar 26 | United International Pictures | false |
| 3 | Date Night | - | - | - | $799,454 | 61 | $1,299,140 | Apr 9 | 20th Century Fox International | false |
| 4 | Alice in Wonderland | - | - | - | $794,097 | 92 | $4,335,113 | Mar 5 | Walt Disney Pictures | false |
| 5 | The Bounty Hunter | - | - | - | $630,483 | 40 | $673,976 | Mar 31 | Sony Pictures Releasing | false |
| 6 | The Book of Eli | - | - | - | $591,759 | 63 | $996,734 | Mar 26 | Sony Pictures Releasing | false |
| 7 | Did You Hear About the Morgans? | - | - | - | $212,756 | 40 | $253,991 | Apr 16 | Sony Pictures Releasing | false |
| 8 | Case 39 | - | - | - | $209,284 | 29 | $265,440 | Apr 9 | United International Pictures | false |
| 9 | Couples Retreat | - | - | - | $198,769 | 33 | $370,826 | Mar 26 | United International Pictures | false |
| 10 | The Haunting in Connecticut | - | - | - | $140,768 | 24 | $275,080 | Mar 26 | - | false |
| 11 | Paranormal Activity | - | - | - | $120,136 | 38 | $349,537 | Apr 23 | - | false |
| 12 | Shutter Island | - | - | - | $103,540 | 44 | $634,691 | Mar 12 | United International Pictures | false |
| 13 | Old Dogs | - | - | - | $102,601 | 51 | $2,468,108 | Feb 5 | United International Pictures | false |
| 14 | The Blind Side | - | - | - | $89,764 | 39 | $355,921 | Mar 19 | Warner Bros. | false |
| 15 | I Hate Valentine's Day | - | - | - | $78,453 | 15 | $150,611 | Apr 16 | - | false |
| 16 | Everybody's Fine | - | - | - | $75,196 | 17 | $124,312 | Apr 9 | Walt Disney Pictures | false |
| 17 | The Imaginarium of Doctor Parnassus | - | - | - | $66,940 | 10 | $113,890 | Apr 16 | Sony Pictures Releasing | false |
| 18 | Edge of Darkness | - | - | - | $65,992 | 50 | $828,534 | Mar 5 | Warner Bros. | false |
| 19 | 500 Days of Summer | - | - | - | $57,087 | 7 | $97,037 | Mar 26 | 20th Century Fox International | false |
| 20 | Dear John | - | - | - | $50,763 | 15 | $141,889 | Apr 23 | Sony Pictures Releasing | false |
| 21 | Desautorizados | - | - | - | $29,242 | 14 | $57,691 | Mar 26 | - | false |
| 22 | Street Fighter: The Legend of Chun-Li | - | - | - | $23,593 | 14 | $40,802 | Apr 23 | - | false |
| 23 | Feast 2010 Re-release | - | - | - | $17,794 | 4 | $30,281 | Mar 19 | - | false |
| 24 | The Return 2010 Re-release | - | - | - | $17,340 | 8 | $129,063 | Feb 26 | - | false |
| 25 | The Hurt Locker | - | - | - | $14,027 | 10 | $198,231 | Feb 19 | - | false |
| 26 | Precious | - | - | - | $7,446 | 11 | $181,250 | Feb 26 | - | false |
| 27 | Tooth Fairy | - | - | - | $5,151 | 60 | $1,769,552 | Jan 15 | 20th Century Fox International | false |
| 28 | The Soloist | - | - | - | $2,145 | 15 | $48,167 | Mar 19 | United International Pictures | false |
| 29 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $2,144 | 69 | $1,517,744 | Feb 12 | 20th Century Fox International | false |
| 30 | Funny People | - | - | - | $1,026 | 20 | $123,884 | Jan 29 | United International Pictures | false |
| 31 | Big Stan | - | - | - | $925 | 10 | $83,115 | Feb 26 | - | false |
| 32 | Invictus | - | - | - | $751 | 34 | $340,248 | Feb 5 | Warner Bros. | false |
| 33 | DOA: Dead or Alive 2009 Re-release | - | - | - | $247 | 12 | $27,650 | Mar 19 | - | false |
