| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Clash of the Titans | - | - | - | $8,400,622 | 533 | $10,275,464 | Apr 16 | Warner Bros. | false |
| 2 | Life Is a Wonderful Thing | - | - | - | $6,084,615 | 410 | $6,161,728 | Apr 2 | Medusa Distribuzione | false |
| 3 | How to Train Your Dragon | - | - | - | $4,710,180 | 488 | $6,505,999 | Mar 26 | Universal Pictures International (UPI) | false |
| 4 | The Ghost Writer | - | - | - | $3,956,474 | 352 | $4,811,454 | Apr 9 | 01 Distribution | false |
| 5 | Happy Family | - | - | - | $3,773,881 | 353 | $6,111,219 | Mar 26 | 01 Distribution | false |
| 6 | Green Zone | - | - | - | $3,318,480 | 301 | $3,636,987 | Apr 9 | Medusa Distribuzione | false |
| 7 | Basilicata Coast to Coast | - | - | - | $2,768,095 | 196 | $4,588,816 | Apr 9 | Eagle Pictures | false |
| 8 | I Love You Phillip Morris | - | - | - | $2,739,427 | 222 | $2,739,427 | Apr 2 | Lucky Red | false |
| 9 | The Bounty Hunter | - | - | - | $2,149,273 | 256 | $2,208,057 | Apr 9 | Sony Pictures Releasing | false |
| 10 | Loose Cannons | - | - | - | $2,084,245 | 427 | $10,994,715 | Mar 12 | 01 Distribution | false |
| 11 | Weddings and Other Disasters | - | - | - | $2,036,271 | 305 | $4,769,415 | Apr 23 | 01 Distribution | false |
| 12 | Alice in Wonderland | - | - | - | $1,995,505 | 668 | $39,952,697 | Mar 3 | Walt Disney Pictures | false |
| 13 | The Concert | - | - | - | $1,896,278 | 139 | $4,825,505 | Feb 5 | BIM Distribuzione | false |
| 14 | Remember Me | - | - | - | $1,291,894 | 335 | $3,008,966 | Mar 26 | Eagle Pictures | false |
| 15 | Gamer | - | - | - | $1,273,677 | 123 | $1,273,677 | Apr 2 | - | false |
| 16 | It's Complicated | - | - | - | $1,252,654 | 302 | $4,985,582 | Mar 19 | United International Pictures | false |
| 17 | From Paris with Love | - | - | - | $1,169,197 | 250 | $1,246,434 | Apr 16 | - | false |
| 18 | Shutter Island | - | - | - | $1,022,942 | 433 | $9,434,156 | Mar 5 | Medusa Distribuzione | false |
| 19 | The Crazies | - | - | - | $931,224 | 283 | $1,499,039 | Apr 23 | Medusa Distribuzione | false |
| 20 | Little Nicholas | - | - | - | $865,411 | 159 | $935,187 | Apr 2 | BIM Distribuzione | false |
| 21 | Cell 211 | - | - | - | $694,643 | 173 | $773,108 | Apr 16 | - | false |
| 22 | Sul mare | - | - | - | $523,238 | 130 | $523,238 | Apr 2 | Warner Bros. | false |
| 23 | Departures | - | - | - | $451,601 | 42 | $868,327 | Apr 9 | - | false |
| 24 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $285,425 | 288 | $4,139,909 | Mar 12 | 20th Century Fox International | false |
| 25 | Fantastic Mr. Fox | - | - | - | $278,265 | 98 | $297,811 | Apr 16 | 20th Century Fox International | false |
| 26 | A Prophet | - | - | - | $265,291 | 81 | $794,872 | Mar 19 | BIM Distribuzione | false |
| 27 | Genitori & figli:) - Agitare bene prima dell'uso | - | - | - | $241,665 | 471 | $11,455,266 | Feb 26 | Filmauro | false |
| 28 | Daybreakers | - | - | - | $236,385 | 146 | $770,682 | Mar 26 | Sony Pictures Releasing | false |
| 29 | La valigia sul letto | - | - | - | $166,040 | 85 | $763,063 | Mar 12 | Medusa Distribuzione | false |
| 30 | No One Knows About Persian Cats | - | - | - | $163,392 | 38 | $217,434 | Apr 16 | BIM Distribuzione | false |
| 31 | Simon Konianski | - | - | - | $141,998 | 25 | $150,872 | Apr 9 | Fandango | false |
| 32 | Invictus | - | - | - | $90,625 | 418 | $9,063,387 | Feb 26 | Warner Bros. | false |
| 33 | I Am Love | - | - | - | $80,194 | 42 | $284,612 | Mar 19 | Mikado Film | false |
| 34 | Edge of Darkness | - | - | - | $70,844 | 272 | $1,820,221 | Mar 19 | 01 Distribution | false |
| 35 | Women Without Men | - | - | - | $51,337 | 33 | $368,804 | Mar 12 | BIM Distribuzione | false |
| 36 | Leap Year | - | - | - | $36,639 | 50 | $36,639 | Apr 9 | - | false |
| 37 | Incendiary | - | - | - | $28,885 | 9 | $143,379 | Feb 26 | - | false |
| 38 | Diamond 13 | - | - | - | $28,885 | 6 | $121,631 | Mar 5 | - | false |
| 39 | Sunshine Cleaning | - | - | - | $19,064 | 27 | $19,064 | Apr 9 | - | false |
| 40 | Extraordinary Measures | - | - | - | $14,111 | 12 | $14,921 | Apr 23 | Sony Pictures Releasing | false |
| 41 | The Messenger | - | - | - | $13,569 | 24 | $78,366 | Apr 16 | Lucky Red | false |
| 42 | Le Bossu | - | - | - | $10,396 | 1 | $58,518 | Dec 31 | - | false |
| 43 | The Man Who Will Come | - | - | - | $9,130 | 69 | $1,877,452 | Jan 22 | Mikado Film | false |
| 44 | Tutto l'amore del mondo | - | - | - | $9,124 | 268 | $1,192,420 | Mar 19 | Medusa Distribuzione | false |
| 45 | Old Dogs | - | - | - | $8,573 | 7 | $23,802 | Mar 26 | Walt Disney Pictures | false |
| 46 | Crazy Heart | - | - | - | $7,286 | 10 | $158,110 | Mar 5 | 20th Century Fox International | false |
| 47 | Legion | - | - | - | $7,024 | 125 | $810,426 | Mar 12 | Sony Pictures Releasing | false |
| 48 | The First Beautiful Thing | - | - | - | $6,633 | 350 | $9,115,665 | Jan 15 | Medusa Distribuzione | false |
| 49 | Leaving | - | - | - | $6,002 | 43 | $410,506 | Mar 5 | Teodora Film | false |
| 50 | Kicked in the Head | - | - | - | $5,465 | 3 | $21,361 | Aug 28 | - | false |
| 51 | Lourdes | - | - | - | $3,908 | 83 | $510,877 | Feb 11 | - | false |
| 52 | An Education | - | - | - | $815 | 37 | $536,758 | Feb 5 | Sony Pictures Releasing | false |
