| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Clash of the Titans | - | - | - | $130,096 | 8 | $136,087 | Apr 9 | Warner Bros. | false |
| 2 | How to Train Your Dragon | - | - | - | $121,934 | 9 | $168,995 | Apr 2 | United International Pictures | false |
| 3 | Kick-Ass | - | - | - | $90,472 | 5 | $135,879 | Apr 16 | - | false |
| 4 | Hot Tub Time Machine | - | - | - | $87,828 | 4 | $109,455 | Mar 31 | - | false |
| 5 | I Love You Phillip Morris | - | - | - | $54,636 | 3 | $70,789 | Apr 2 | - | false |
| 6 | Date Night | - | - | - | $49,998 | 4 | $65,687 | Apr 9 | 20th Century Fox International | false |
| 7 | King's Road | - | - | - | $32,006 | 3 | $62,389 | Mar 26 | - | false |
| 8 | Dear John | - | - | - | $18,821 | 3 | $22,088 | Mar 31 | - | false |
| 9 | The Bounty Hunter | - | - | - | $16,202 | 4 | $83,862 | Mar 19 | Sony Pictures Releasing | false |
| 10 | She's Out of My League | - | - | - | $15,976 | 4 | $38,520 | Apr 23 | United International Pictures | false |
| 11 | Nanny McPhee Returns | - | - | - | $13,407 | 4 | $29,775 | Mar 26 | United International Pictures | false |
| 12 | Alice in Wonderland | - | - | - | $12,325 | 6 | $215,744 | Mar 5 | Walt Disney Pictures | false |
| 13 | Crazy Heart | - | - | - | $12,233 | 1 | $20,680 | Apr 16 | 20th Century Fox International | false |
| 14 | The Crazies | - | - | - | $10,692 | 2 | $12,529 | Apr 16 | - | false |
| 15 | The Girl Who Kicked the Hornet's Nest | - | - | - | $10,357 | 5 | $186,189 | Feb 19 | - | false |
| 16 | The Spy Next Door 2010 Re-release | - | - | - | $10,255 | 3 | $15,768 | Apr 16 | - | false |
| 17 | When in Rome | - | - | - | $9,220 | 3 | $21,377 | Mar 26 | Walt Disney Pictures | false |
| 18 | The Blind Side | - | - | - | $6,921 | 3 | $47,982 | Mar 12 | Warner Bros. | false |
| 19 | Astro Boy | - | - | - | $6,067 | 7 | $21,892 | Apr 23 | - | false |
| 20 | The Men Who Stare at Goats | - | - | - | $5,354 | 2 | $15,186 | Mar 26 | - | false |
| 21 | Green Zone | - | - | - | $3,811 | 4 | $64,727 | Mar 12 | United International Pictures | false |
| 22 | The Good Heart | - | - | - | $3,236 | 2 | $30,223 | Mar 5 | - | false |
| 23 | The Imaginarium of Doctor Parnassus | - | - | - | $3,059 | 1 | $8,331 | Apr 16 | - | false |
| 24 | Shutter Island | - | - | - | $2,607 | 4 | $120,750 | Feb 26 | United International Pictures | false |
| 25 | The Lovely Bones | - | - | - | $2,402 | 2 | $12,700 | Mar 19 | United International Pictures | false |
| 26 | Cloudy with a Chance of Meatballs | - | - | - | $2,093 | 7 | $92,303 | Jan 29 | Sony Pictures Releasing | false |
| 27 | Daybreakers | - | - | - | $1,724 | 2 | $13,394 | Mar 19 | - | false |
| 28 | The White Ribbon | - | - | - | $795 | 1 | $795 | Apr 23 | - | false |
| 29 | Avatar | - | - | - | $683 | 12 | $1,131,489 | Dec 18 | 20th Century Fox International | false |
| 30 | Earth | - | - | - | $659 | 1 | $3,654 | Mar 26 | - | false |
| 31 | Nowhere Boy | - | - | - | $411 | 1 | $411 | Apr 16 | - | false |
| 32 | Fantastic Mr. Fox | - | - | - | $230 | 1 | $230 | Apr 16 | 20th Century Fox International | false |
