| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | How to Train Your Dragon | - | - | - | $22,048,485 | 490 | $26,488,493 | Apr 2 | Paramount Pictures International | false |
| 2 | Nanny McPhee and the Big Bang | - | - | - | $16,368,814 | 529 | $23,571,491 | Mar 26 | Universal Pictures International (UPI) | false |
| 3 | Kick-Ass | - | - | - | $16,179,668 | 424 | $16,763,505 | Apr 2 | Universal Pictures International (UPI) | false |
| 4 | Alice in Wonderland | - | - | - | $8,470,151 | 533 | $64,437,055 | Mar 5 | Walt Disney Pictures | false |
| 5 | Dear John | - | - | - | $6,141,193 | 415 | $7,918,385 | Apr 16 | Paramount Pictures International | false |
| 6 | Remember Me | - | - | - | $5,494,638 | 364 | $5,494,638 | Apr 2 | Entertainment One | false |
| 7 | The Blind Side | - | - | - | $5,477,463 | 371 | $9,127,125 | Mar 26 | Warner Bros. | false |
| 8 | The Ghost Writer | - | - | - | $3,687,434 | 343 | $5,719,387 | Apr 16 | Optimum Releasing | false |
| 9 | Shutter Island | - | - | - | $3,444,822 | 419 | $16,304,568 | Mar 12 | Paramount Pictures International | false |
| 10 | Date Night | - | - | - | $2,814,308 | 403 | $5,518,097 | Apr 23 | 20th Century Fox International | false |
| 11 | The Bounty Hunter | - | - | - | $1,949,949 | 394 | $8,998,455 | Mar 19 | Sony Pictures Releasing | false |
| 12 | Cemetery Junction | - | - | - | $1,915,303 | 330 | $2,030,778 | Apr 16 | Sony Pictures Releasing | false |
| 13 | The Spy Next Door 2010 Re-release | - | - | - | $1,660,998 | 332 | $3,971,159 | Mar 19 | Paramount Pictures International | false |
| 14 | It's a Wonderful Afterlife | - | - | - | $975,899 | 294 | $1,243,650 | Apr 2 | Icon Film Distribution Australia | false |
| 15 | The Infidel | - | - | - | $681,346 | 57 | $681,346 | Apr 9 | Revolver Entertainment | false |
| 16 | I Am Love | - | - | - | $620,954 | 47 | $620,954 | Apr 9 | Metrodome Distribution | false |
| 17 | The Joneses | - | - | - | $617,134 | 217 | $786,455 | Apr 23 | Entertainment One | false |
| 18 | Whip It | - | - | - | $542,864 | 315 | $542,864 | Apr 9 | Lionsgate | false |
| 19 | Repo Men | - | - | - | $280,925 | 243 | $280,925 | Apr 16 | Universal Pictures International (UPI) | false |
| 20 | Green Zone | - | - | - | $259,344 | 419 | $8,259,161 | Mar 12 | Universal Pictures International (UPI) | false |
| 21 | 6 Souls | - | - | - | $217,508 | 177 | $217,508 | Apr 9 | Revolver Entertainment | false |
| 22 | The Girl with the Dragon Tattoo | - | - | - | $179,067 | 126 | $2,342,433 | Mar 12 | Momentum Pictures | false |
| 23 | Centurion | - | - | - | $175,581 | 102 | $175,581 | Apr 23 | Warner Bros. | false |
| 24 | I Love You Phillip Morris | - | - | - | $171,480 | 342 | $3,496,127 | Mar 19 | Entertainment One | false |
| 25 | Avatar | - | - | - | $163,709 | 503 | $147,646,580 | Dec 18 | 20th Century Fox International | false |
| 26 | Prince | - | - | - | $104,988 | 45 | $104,988 | Apr 9 | - | false |
| 27 | Shank | - | - | - | $104,782 | 86 | $713,697 | Mar 26 | Revolver Entertainment | false |
| 28 | Clash of the Titans | - | - | - | $30,561 | 468 | $29,242,160 | Apr 2 | Warner Bros. | false |
