| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Clash of the Titans | - | - | - | $1,337,896 | 103 | $1,828,161 | Apr 15 | Warner Bros. | false |
| 2 | How to Train Your Dragon | - | - | - | $953,008 | 69 | $1,511,998 | Mar 25 | United International Pictures | false |
| 3 | Shutter Island | - | - | - | $520,273 | 35 | $739,576 | Apr 8 | United International Pictures | false |
| 4 | Legion | - | - | - | $283,243 | 26 | $444,893 | Mar 25 | Sony Pictures Releasing | false |
| 5 | Edge of Darkness | - | - | - | $181,649 | 30 | $184,033 | Apr 1 | Warner Bros. | false |
| 6 | Avatar | - | - | - | $177,849 | 124 | $10,818,765 | Dec 17 | 20th Century Fox International | false |
| 7 | The Bounty Hunter | - | - | - | $59,842 | 22 | $113,902 | Apr 22 | Sony Pictures Releasing | false |
| 8 | Daybreakers | - | - | - | $57,718 | 16 | $57,831 | Apr 1 | - | false |
| 9 | The Hurt Locker | - | - | - | $51,403 | 21 | $348,664 | Feb 18 | - | false |
| 10 | The Young Victoria | - | - | - | $50,288 | 8 | $71,748 | Apr 15 | - | false |
| 11 | 500 Days of Summer | - | - | - | $46,226 | 8 | $132,235 | Mar 11 | 20th Century Fox International | false |
| 12 | Remember Me | - | - | - | $42,687 | 17 | $103,496 | Apr 22 | - | false |
| 13 | The Men Who Stare at Goats | - | - | - | $40,798 | 9 | $42,713 | Apr 1 | Sony Pictures Releasing | false |
| 14 | Let the Right One In | - | - | - | $40,337 | 5 | $54,580 | Mar 25 | - | false |
| 15 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $39,321 | 50 | $803,087 | Feb 11 | 20th Century Fox International | false |
| 16 | The Girl with the Dragon Tattoo | - | - | - | $37,882 | 12 | $144,435 | Apr 22 | Andes Films | false |
| 17 | The Blind Side | - | - | - | $37,211 | 8 | $96,354 | Mar 18 | Warner Bros. | false |
| 18 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $33,763 | 54 | $1,424,935 | Jan 28 | 20th Century Fox International | false |
| 19 | The Haunting in Connecticut | - | - | - | $31,227 | 13 | $214,186 | Jan 14 | Transeuropa | false |
| 20 | [Rec]² | - | - | - | $30,556 | 16 | $96,032 | Mar 18 | - | false |
| 21 | The Secret in Their Eyes | - | - | - | $29,858 | 3 | $446,321 | Jan 7 | - | false |
| 22 | My Life in Ruins | - | - | - | $25,761 | 15 | $25,982 | Apr 8 | - | false |
| 23 | Law Abiding Citizen | - | - | - | $22,943 | 19 | $29,385 | Apr 22 | Transeuropa | false |
| 24 | The Box | - | - | - | $22,732 | 18 | $55,749 | Mar 25 | - | false |
| 25 | The Lovely Bones | - | - | - | $17,011 | 33 | $276,533 | Feb 18 | United International Pictures | false |
| 26 | Amelia | - | - | - | $10,020 | 7 | $10,020 | Apr 8 | 20th Century Fox International | false |
| 27 | My Best Friend's Girl | - | - | - | $9,471 | 15 | $59,152 | Mar 18 | Transeuropa | false |
| 28 | The Burning Plain | - | - | - | $7,862 | 3 | $8,106 | Apr 8 | - | false |
| 29 | Halloween II | - | - | - | $7,096 | 16 | $63,966 | Mar 11 | - | false |
| 30 | The Wolfman | - | - | - | $6,931 | 44 | $762,258 | Feb 11 | United International Pictures | false |
| 31 | Invictus | - | - | - | $3,955 | 20 | $203,487 | Feb 4 | Warner Bros. | false |
| 32 | Up in the Air | - | - | - | $3,559 | 21 | $151,820 | Feb 4 | United International Pictures | false |
| 33 | Valentine's Day | - | - | - | $3,140 | 32 | $320,998 | Feb 11 | Warner Bros. | false |
| 34 | The Imaginarium of Doctor Parnassus | - | - | - | $2,948 | 6 | $90,374 | Jan 28 | Sony Pictures Releasing | false |
| 35 | Nine | - | - | - | $2,815 | 12 | $51,640 | Feb 18 | Sony Pictures Releasing | false |
| 36 | Everybody's Fine | - | - | - | $2,206 | 8 | $32,530 | Feb 25 | Walt Disney Pictures | false |
| 37 | Precious | - | - | - | $1,962 | 4 | $45,371 | Feb 25 | - | false |
| 38 | Ponyo | - | - | - | $1,920 | 8 | $36,353 | Feb 25 | Andes Films | false |
| 39 | An Education | - | - | - | $796 | 5 | $27,571 | Jan 21 | Sony Pictures Releasing | false |
