| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Clash of the Titans | - | - | - | $1,332,420 | 41 | $1,936,590 | Apr 22 | Warner Bros. | false |
| 2 | How to Train Your Dragon | - | - | - | $1,256,514 | 28 | $1,858,317 | Mar 25 | United International Pictures | false |
| 3 | Alice in Wonderland | - | - | - | $449,258 | 26 | $2,376,268 | Mar 4 | - | false |
| 4 | Date Night | - | - | - | $399,720 | 27 | $506,879 | Apr 8 | 20th Century Fox International | false |
| 5 | The Bounty Hunter | - | - | - | $390,154 | 24 | $772,333 | Mar 25 | Sony Pictures Releasing | false |
| 6 | Tooth Fairy | - | - | - | $330,199 | 24 | $383,439 | Apr 1 | 20th Century Fox International | false |
| 7 | Repo Men | - | - | - | $326,930 | 24 | $326,930 | Apr 8 | United International Pictures | false |
| 8 | Nanny McPhee Returns | - | - | - | $276,934 | 23 | $407,596 | Apr 15 | United International Pictures | false |
| 9 | Remember Me | - | - | - | $208,911 | 23 | $208,911 | Apr 1 | Gulf Film | false |
| 10 | The Fourth Kind | - | - | - | $199,390 | 26 | $199,654 | Apr 15 | Gulf Film | false |
| 11 | Green Zone | - | - | - | $159,749 | 25 | $747,178 | Mar 18 | United International Pictures | false |
| 12 | Brooklyn's Finest | - | - | - | $148,186 | 24 | $217,543 | Apr 22 | Gulf Film | false |
| 13 | The Descent: Part 2 | - | - | - | $119,827 | 20 | $119,827 | Apr 8 | Gulf Film | false |
| 14 | The Haunting of Molly Hartley | - | - | - | $111,269 | 20 | $111,269 | Apr 1 | Gulf Film | false |
| 15 | Dark Floors 2010 Re-release | - | - | - | $96,292 | 10 | $96,808 | Apr 1 | Gulf Film | false |
| 16 | Shutter Island | - | - | - | $82,763 | 29 | $769,876 | Mar 11 | United International Pictures | false |
| 17 | Daybreakers | - | - | - | $76,834 | 24 | $284,994 | Mar 25 | Gulf Film | false |
| 18 | The Last Song | - | - | - | $66,932 | 12 | $149,188 | Apr 22 | Walt Disney Pictures | false |
| 19 | 9 | - | - | - | $66,228 | 12 | $68,139 | Apr 15 | Italian International Film | false |
| 20 | Avatar | - | - | - | $42,680 | 45 | $7,311,410 | Dec 17 | 20th Century Fox International | false |
| 21 | Brothers | - | - | - | $42,606 | 15 | $65,090 | Apr 22 | Gulf Film | false |
| 22 | An Education | - | - | - | $38,137 | 12 | $39,000 | Apr 15 | Gulf Film | false |
| 23 | Hachi: A Dog's Tale | - | - | - | $33,389 | 6 | $34,508 | Apr 8 | Gulf Film | false |
| 24 | Blackout 2009 Re-release | - | - | - | $30,374 | 10 | $37,464 | Apr 22 | Gulf Film | false |
| 25 | Triangle | - | - | - | $29,442 | 5 | $29,442 | Apr 15 | - | false |
| 26 | The Road | - | - | - | $18,679 | 13 | $74,722 | Mar 25 | Gulf Film | false |
| 27 | The Hurt Locker | - | - | - | $17,319 | 12 | $197,946 | Feb 11 | Gulf Film | false |
| 28 | Cop Out | - | - | - | $16,991 | 24 | $507,959 | Mar 11 | Warner Bros. | false |
| 29 | Black Dynamite | - | - | - | $12,394 | 11 | $17,183 | Apr 8 | - | false |
| 30 | The Spy Next Door 2010 Re-release | - | - | - | $4,717 | 23 | $740,937 | Feb 11 | Gulf Film | false |
| 31 | Newcastle | - | - | - | $3,268 | 5 | $4,567 | Apr 8 | - | false |
| 32 | Captain Alatriste: The Spanish Musketeer 2010 Re-release | - | - | - | $2,998 | 1 | $143,750 | Apr 1 | Italian International Film | false |
| 33 | Invictus | - | - | - | $1,764 | 17 | $119,506 | Mar 4 | Warner Bros. | false |
| 34 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $1,732 | 23 | $257,582 | Feb 25 | 20th Century Fox International | false |
| 35 | Dear John | - | - | - | $1,650 | 22 | $156,577 | Mar 11 | Gulf Film | false |
| 36 | Edge of Darkness | - | - | - | $1,199 | 24 | $569,429 | Mar 4 | Gulf Film | false |
| 37 | Prince of the Seas | - | - | - | $673 | 23 | $644,611 | Feb 25 | Gulf Film | false |
| 38 | Five Minutes of Heaven | - | - | - | $370 | 10 | $26,361 | Mar 18 | Gulf Film | false |
| 39 | Samson & Delilah | - | - | - | $131 | 1 | $131 | Apr 8 | Gulf Film | false |
