| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Fast & Furious | - | - | - | $9,417,295 | 422 | $11,161,012 | Apr 17 | United International Pictures | false |
| 2 | Monsters vs. Aliens | - | - | - | $9,150,832 | 496 | $10,546,331 | Apr 3 | United International Pictures | false |
| 3 | Marley & Me | - | - | - | $6,353,097 | 348 | $6,737,110 | Apr 3 | 20th Century Fox International | false |
| 4 | The Friends at the Margherita Cafe | - | - | - | $3,654,360 | 265 | $4,326,733 | Apr 3 | 01 Distribution | false |
| 5 | Gran Torino | - | - | - | $3,128,346 | 332 | $12,993,866 | Mar 13 | Warner Bros. | false |
| 6 | Duplicity | - | - | - | $2,761,789 | 203 | $2,847,062 | Apr 10 | United International Pictures | false |
| 7 | Dragonball Evolution | - | - | - | $2,651,745 | 328 | $2,661,061 | Apr 10 | 20th Century Fox International | false |
| 8 | Che: Part One | - | - | - | $2,482,899 | 208 | $2,749,408 | Apr 10 | BIM Distribuzione | false |
| 9 | Questione di cuore | - | - | - | $2,383,070 | 264 | $3,919,677 | Apr 17 | 01 Distribution | false |
| 10 | Sbirri | - | - | - | $2,161,629 | 224 | $2,385,262 | Apr 10 | Medusa Distribuzione | false |
| 11 | Make It Happen | - | - | - | $1,588,417 | 263 | $1,588,417 | Apr 3 | Medusa Distribuzione | false |
| 12 | What Just Happened | - | - | - | $1,309,734 | 275 | $1,350,455 | Apr 17 | Medusa Distribuzione | false |
| 13 | Generazione mille euro | - | - | - | $990,230 | 267 | $1,712,362 | Apr 24 | 01 Distribution | false |
| 14 | Death Defying Acts | - | - | - | $950,924 | 187 | $1,628,520 | Apr 24 | Eagle Pictures | false |
| 15 | The New Monsters Today | - | - | - | $700,589 | 406 | $2,486,257 | Mar 27 | Warner Bros. | false |
| 16 | Different from Whom | - | - | - | $674,867 | 364 | $4,602,897 | Mar 20 | United International Pictures | false |
| 17 | Franklyn | - | - | - | $662,486 | 149 | $700,561 | Apr 17 | Sony Pictures Releasing | false |
| 18 | Push | - | - | - | $637,725 | 197 | $1,902,080 | Mar 27 | Eagle Pictures | false |
| 19 | Louise hires a contract killer | - | - | - | $565,393 | 48 | $803,171 | Apr 3 | Fandango | false |
| 20 | Two Lovers | - | - | - | $542,087 | 108 | $1,339,026 | Mar 27 | BIM Distribuzione | false |
| 21 | La matassa | - | - | - | $517,132 | 514 | $10,007,765 | Mar 13 | Medusa Distribuzione | false |
| 22 | Earth | - | - | - | $459,135 | 87 | $1,046,151 | Apr 22 | Walt Disney Pictures | false |
| 23 | He's Just Not That Into You | - | - | - | $402,456 | 323 | $3,508,807 | Mar 20 | 01 Distribution | false |
| 24 | The Tale of Despereaux | - | - | - | $345,338 | 103 | $645,683 | Apr 24 | United International Pictures | false |
| 25 | RocknRolla | - | - | - | $344,773 | 138 | $386,404 | Apr 24 | Walt Disney Pictures | false |
| 26 | Bedtime Stories | - | - | - | $278,722 | 87 | $899,750 | Mar 27 | Walt Disney Pictures | false |
| 27 | Tutta colpa di Giuda | - | - | - | $237,843 | 74 | $353,690 | Apr 10 | Warner Bros. | false |
| 28 | Chef's Special 2009 Re-release | - | - | - | $216,763 | 97 | $514,692 | Apr 24 | - | false |
| 29 | Fort Apache Napoli | - | - | - | $212,833 | 112 | $785,422 | Mar 27 | 01 Distribution | false |
| 30 | The Case of Unfaithful Klara | - | - | - | $148,916 | 262 | $991,709 | Mar 27 | Medusa Distribuzione | false |
| 31 | Ponyo | - | - | - | $118,304 | 184 | $1,013,560 | Mar 20 | Lucky Red | false |
| 32 | The International | - | - | - | $58,397 | 170 | $1,375,443 | Mar 20 | Sony Pictures Releasing | false |
| 33 | Public Enemy | - | - | - | $50,823 | 23 | $50,823 | Apr 17 | Eagle Pictures | false |
| 34 | Slumdog Millionaire | - | - | - | $45,545 | 160 | $9,341,549 | Dec 5 | Lucky Red | false |
| 35 | The Hush | - | - | - | $44,092 | - | $44,461 | Apr 17 | - | false |
| 36 | Teza | - | - | - | $37,785 | 21 | $122,720 | Mar 27 | Ripley's Film | false |
| 37 | The Reader | - | - | - | $27,756 | 161 | $3,645,596 | Feb 20 | 01 Distribution | false |
| 38 | Cenci in Cina | - | - | - | $27,525 | 7 | $129,951 | Mar 27 | - | false |
| 39 | The Wrestler | - | - | - | $26,517 | 315 | $2,824,964 | Mar 6 | Lucky Red | false |
| 40 | Frozen River | - | - | - | $19,930 | 20 | $267,882 | Mar 13 | Archibald | false |
| 41 | The Wave | - | - | - | $19,075 | 57 | $696,752 | Feb 27 | BIM Distribuzione | false |
| 42 | Due partite | - | - | - | $16,400 | 210 | $2,027,829 | Mar 6 | 01 Distribution | false |
| 43 | Katyn | - | - | - | $11,603 | 11 | $99,729 | Feb 13 | - | false |
| 44 | Trappola d'autore | - | - | - | $10,775 | 9 | $118,875 | Mar 27 | - | false |
| 45 | Easy Virtue | - | - | - | $8,488 | 142 | $3,590,951 | Jan 9 | Eagle Pictures | false |
| 46 | The Curious Case of Benjamin Button | - | - | - | $6,057 | 502 | $15,750,900 | Feb 13 | Warner Bros. | false |
| 47 | Giulia Doesn't Date at Night | - | - | - | $4,754 | 179 | $1,118,316 | Feb 27 | 01 Distribution | false |
| 48 | Ex | - | - | - | $4,344 | 571 | $15,340,865 | Feb 6 | 01 Distribution | false |
| 49 | Revolutionary Road | - | - | - | $3,418 | 281 | $4,832,138 | Jan 30 | Universal Pictures International (UPI) | false |
| 50 | The Sicilian Girl | - | - | - | $3,403 | 53 | $199,438 | Feb 27 | Istituto Luce | false |
| 51 | Inkheart | - | - | - | $3,168 | 269 | $3,289,477 | Feb 20 | Eagle Pictures | false |
| 52 | Il solitario | - | - | - | $2,870 | 1 | $8,799 | Apr 3 | - | false |
| 53 | Watchmen | - | - | - | $2,712 | 344 | $3,721,232 | Mar 6 | Universal Pictures International (UPI) | false |
| 54 | Lemon Tree | - | - | - | $2,273 | 47 | $1,471,720 | Dec 12 | Teodora Film | false |
| 55 | L'ultimo Crodino | - | - | - | $2,026 | 101 | $106,456 | Mar 20 | Mikado Film | false |
| 56 | Milk | - | - | - | $1,673 | 174 | $3,202,523 | Jan 23 | BIM Distribuzione | false |
| 57 | Mar nero | - | - | - | $1,550 | 10 | $128,060 | Jan 30 | - | false |
| 58 | Dall'altra parte del mare | - | - | - | $1,543 | 1 | $2,945 | Mar 27 | - | false |
| 59 | Pa-ra-da | - | - | - | $1,520 | 52 | $305,344 | Sep 19 | 01 Distribution | false |
| 60 | Legami di sangue | - | - | - | $1,449 | 1 | $2,858 | Mar 27 | - | false |
| 61 | Eden Is West | - | - | - | $1,383 | 179 | $550,811 | Mar 6 | Medusa Distribuzione | false |
| 62 | Empties | - | - | - | $1,317 | 23 | $428,775 | Jan 16 | Fandango | false |
| 63 | One Day in a Life | - | - | - | $1,317 | 12 | $428,775 | Nov 7 | Ripley's Film | false |
| 64 | Juno | - | - | - | $1,099 | 239 | $3,352,339 | Apr 4 | 20th Century Fox International | false |
| 65 | Confessions of a Shopaholic | - | - | - | $1,014 | 369 | $6,192,300 | Feb 27 | Walt Disney Pictures | false |
| 66 | Frost/Nixon | - | - | - | $939 | 151 | $879,567 | Feb 6 | Universal Pictures International (UPI) | false |
| 67 | The Duchess | - | - | - | $776 | 202 | $2,901,441 | Dec 24 | BIM Distribuzione | false |
