| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Monsters vs. Aliens | - | - | - | $791,597 | 79 | $1,036,375 | Apr 2 | United International Pictures | false |
| 2 | Race to Witch Mountain | - | - | - | $460,935 | 36 | $674,840 | Apr 9 | Walt Disney Pictures | false |
| 3 | Dragonball Evolution | - | - | - | $333,888 | 57 | $357,254 | Apr 9 | 20th Century Fox International | false |
| 4 | The Unborn | - | - | - | $183,372 | 29 | $344,528 | Apr 16 | United International Pictures | false |
| 5 | Gran Torino | - | - | - | $162,079 | 15 | $356,118 | Mar 19 | Warner Bros. | false |
| 6 | Underworld: Rise of the Lycans | - | - | - | $154,053 | 31 | $316,294 | Mar 19 | Sony Pictures Releasing | false |
| 7 | Slumdog Millionaire | - | - | - | $138,531 | 21 | $764,404 | Feb 19 | Bazuca Films | false |
| 8 | Earth | - | - | - | $101,696 | 20 | $372,880 | Apr 22 | Walt Disney Pictures | false |
| 9 | Bedtime Stories | - | - | - | $91,753 | 36 | $1,019,509 | Feb 19 | Walt Disney Pictures | false |
| 10 | Changeling | - | - | - | $79,167 | 33 | $260,517 | Mar 12 | United International Pictures | false |
| 11 | Confessions of a Shopaholic | - | - | - | $71,122 | 21 | $106,491 | Mar 26 | Walt Disney Pictures | false |
| 12 | 17 Again | - | - | - | $57,458 | 22 | $136,867 | Apr 23 | Warner Bros. | false |
| 13 | Reincarnation 2009 Re-release | - | - | - | $50,702 | 7 | $68,087 | Mar 26 | Andes Films | false |
| 14 | Paul Blart: Mall Cop | - | - | - | $44,690 | 25 | $69,509 | Apr 23 | Sony Pictures Releasing | false |
| 15 | The Wrestler | - | - | - | $41,552 | 14 | $71,088 | Apr 23 | - | false |
| 16 | He's Just Not That Into You | - | - | - | $37,272 | 22 | $279,930 | Feb 12 | Warner Bros. | false |
| 17 | Death Sentence | - | - | - | $36,761 | 16 | $38,016 | Apr 16 | - | false |
| 18 | Milk | - | - | - | $28,095 | 6 | $41,028 | Mar 26 | United International Pictures | false |
| 19 | Sex Drive | - | - | - | $24,700 | 13 | $24,700 | Apr 9 | - | false |
| 20 | Doubt | - | - | - | $22,582 | 7 | $133,548 | Feb 26 | Walt Disney Pictures | false |
| 21 | Friday the 13th | - | - | - | $14,792 | 22 | $270,539 | Feb 12 | United International Pictures | false |
| 22 | Valkyrie | - | - | - | $12,995 | 43 | $788,657 | Feb 12 | 20th Century Fox International | false |
| 23 | My Brother is an Only Child | - | - | - | $10,770 | 1 | $11,752 | Apr 9 | Transeuropa | false |
| 24 | The Curious Case of Benjamin Button | - | - | - | $9,615 | 36 | $1,109,721 | Jan 22 | Warner Bros. | false |
| 25 | Watchmen | - | - | - | $8,162 | 36 | $214,235 | Mar 5 | United International Pictures | false |
| 26 | Impy's Island | - | - | - | $8,071 | 16 | $117,488 | Mar 5 | Bazuca Films | false |
| 27 | Alpha Dog | - | - | - | $7,664 | 5 | $7,664 | Apr 16 | Andes Films | false |
| 28 | Planet Terror | - | - | - | $7,013 | 10 | $16,907 | Mar 26 | Bazuca Films | false |
| 29 | The Duchess | - | - | - | $6,479 | 11 | $75,042 | Feb 19 | United International Pictures | false |
| 30 | Righteous Kill | - | - | - | $5,636 | 18 | $75,329 | Mar 5 | CDI Films | false |
| 31 | Descendents | - | - | - | $4,697 | 21 | $30,775 | Mar 19 | - | false |
| 32 | Frost/Nixon | - | - | - | $4,457 | 2 | $4,716 | Apr 2 | United International Pictures | false |
| 33 | Hotel for Dogs | - | - | - | $2,750 | 23 | $269,095 | Jan 22 | United International Pictures | false |
| 34 | Flawless | - | - | - | $2,055 | 10 | $25,274 | Feb 26 | Bazuca Films | false |
| 35 | Seven Pounds | - | - | - | $2,029 | 15 | $95,209 | Feb 19 | Sony Pictures Releasing | false |
| 36 | Jonas Brothers: The 3D Concert Experience | - | - | - | $1,748 | 9 | $126,592 | Mar 5 | Walt Disney Pictures | false |
| 37 | Inkheart | - | - | - | $1,479 | 45 | $369,600 | Feb 5 | Warner Bros. | false |
| 38 | The Strangers | - | - | - | $733 | 13 | $115,005 | Jan 22 | Bazuca Films | false |
| 39 | Coraline | - | - | - | $715 | 26 | $332,484 | Feb 5 | United International Pictures | false |
| 40 | Family Hero | - | - | - | $357 | 3 | $29,101 | Feb 12 | Andes Films | false |
| 41 | The Boy in the Striped Pajamas | - | - | - | $356 | 14 | $259,677 | Jan 15 | Walt Disney Pictures | false |
| 42 | Deception | - | - | - | $352 | 8 | $13,500 | Mar 19 | Bazuca Films | false |
| 43 | Che: Part One | - | - | - | $290 | 17 | $128,625 | Jan 29 | Bazuca Films | false |
| 44 | Four Minutes | - | - | - | $278 | 2 | $3,099 | Mar 26 | Transeuropa | false |
| 45 | Bolt | - | - | - | $276 | 62 | $1,788,695 | Dec 25 | Walt Disney Pictures | false |
| 46 | The Bank Job | - | - | - | $125 | 12 | $51,184 | Feb 26 | Transeuropa | false |
| 47 | The Tale of Despereaux | - | - | - | $49 | 33 | $158,946 | Jan 29 | United International Pictures | false |
