| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Horton Hears a Who! | - | - | - | $589,639 | 86 | $1,022,212 | Mar 28 | NuMetro Distribution | false |
| 2 | The Game Plan | - | - | - | $567,515 | 55 | $1,400,843 | Mar 21 | Ster-Kinekor Pictures | false |
| 3 | Step Up 2 the Streets | - | - | - | $537,972 | 52 | $1,539,565 | Mar 14 | NuMetro Distribution | false |
| 4 | Vantage Point | - | - | - | $339,971 | 45 | $362,786 | Apr 4 | United International Pictures | false |
| 5 | Mad Money | - | - | - | $324,151 | 44 | $534,907 | Apr 18 | NuMetro Distribution | false |
| 6 | Bakgat! | - | - | - | $267,786 | 41 | $373,635 | Apr 11 | Ster-Kinekor Pictures | false |
| 7 | Fool's Gold | - | - | - | $224,519 | 60 | $956,530 | Mar 7 | NuMetro Distribution | false |
| 8 | Nim's Island | - | - | - | $204,583 | 43 | $418,418 | Apr 25 | NuMetro Distribution | false |
| 9 | Street Kings | - | - | - | $193,769 | 40 | $248,127 | Apr 18 | 20th Century Fox International | false |
| 10 | The Nanny Diaries | - | - | - | $192,917 | 40 | $344,095 | Mar 28 | Ster-Kinekor Pictures | false |
| 11 | 10,000 BC | - | - | - | $181,592 | 55 | $682,616 | Mar 21 | NuMetro Distribution | false |
| 12 | Why Did I Get Married? | - | - | - | $168,581 | 26 | $651,350 | Feb 29 | Ster-Kinekor Pictures | false |
| 13 | Dan in Real Life | - | - | - | $152,444 | 39 | $267,573 | Apr 25 | Ster-Kinekor Pictures | false |
| 14 | Untraceable | - | - | - | $134,572 | 44 | $212,073 | Apr 25 | United International Pictures | false |
| 15 | War | - | - | - | $133,548 | 26 | $154,214 | Apr 18 | Ster-Kinekor Pictures | false |
| 16 | Rambo | - | - | - | $123,183 | 44 | $123,183 | Apr 11 | NuMetro Distribution | false |
| 17 | The Other Boleyn Girl | - | - | - | $122,907 | 25 | $175,831 | Apr 18 | Ster-Kinekor Pictures | false |
| 18 | The Spiderwick Chronicles | - | - | - | $114,199 | 54 | $379,348 | Mar 21 | United International Pictures | false |
| 19 | I Could Never Be Your Woman | - | - | - | $101,274 | 20 | $101,274 | Apr 11 | NuMetro Distribution | false |
| 20 | Juno | - | - | - | $100,560 | 32 | $389,224 | Mar 14 | NuMetro Distribution | false |
| 21 | The Kite Runner | - | - | - | $70,424 | 18 | $307,021 | Feb 15 | United International Pictures | false |
| 22 | First Sunday | - | - | - | $63,730 | 20 | $189,960 | Apr 25 | United International Pictures | false |
| 23 | How She Move | - | - | - | $55,999 | 25 | $82,206 | Apr 18 | United International Pictures | false |
| 24 | No Country for Old Men | - | - | - | $54,059 | 12 | $226,075 | Feb 29 | United International Pictures | false |
| 25 | Starter for 10 | - | - | - | $38,638 | 10 | $38,638 | Apr 11 | Ster-Kinekor Pictures | false |
| 26 | Scoop | - | - | - | $31,849 | 10 | $31,849 | Apr 4 | Ster-Kinekor Pictures | false |
| 27 | U Me Aur Hum | - | - | - | $28,033 | 7 | $34,060 | Apr 11 | NuMetro Distribution | false |
| 28 | The Water Horse | - | - | - | $23,101 | 35 | $266,234 | Mar 7 | United International Pictures | false |
| 29 | Atonement | - | - | - | $19,827 | 18 | $387,738 | Feb 1 | United International Pictures | false |
| 30 | One Missed Call | - | - | - | $16,825 | 30 | $195,536 | Mar 14 | NuMetro Distribution | false |
| 31 | Run Fatboy Run | - | - | - | $15,573 | 16 | $36,336 | Apr 25 | NuMetro Distribution | false |
| 32 | Sydney White | - | - | - | $13,448 | 41 | $374,413 | Feb 29 | NuMetro Distribution | false |
| 33 | Jumper | - | - | - | $11,130 | 61 | $875,373 | Feb 15 | NuMetro Distribution | false |
| 34 | Race | - | - | - | $9,531 | 9 | $89,307 | Mar 21 | Ster-Kinekor Pictures | false |
| 35 | More Than Just a Game | - | - | - | $8,875 | 17 | $15,542 | Apr 25 | United International Pictures | false |
| 36 | Love in the Time of Cholera | - | - | - | $8,112 | 21 | $72,593 | Mar 14 | United International Pictures | false |
| 37 | Planet Terror | - | - | - | $8,017 | 13 | $13,539 | Apr 4 | Ster-Kinekor Pictures | false |
| 38 | Grace Is Gone | - | - | - | $7,275 | 10 | $31,984 | Mar 28 | Ster-Kinekor Pictures | false |
| 39 | Charlie Wilson's War | - | - | - | $5,910 | 44 | $153,637 | Mar 7 | United International Pictures | false |
| 40 | The Diving Bell and the Butterfly | - | - | - | $5,272 | 4 | $46,984 | Mar 21 | Ster-Kinekor Pictures | false |
| 41 | Walk Hard: The Dewey Cox Story | - | - | - | $2,569 | 5 | $8,146 | Mar 28 | United International Pictures | false |
| 42 | Good Luck Chuck | - | - | - | $1,241 | 31 | $398,763 | Jan 25 | United International Pictures | false |
| 43 | Things We Lost in the Fire | - | - | - | $124 | 10 | $19,203 | Feb 22 | United International Pictures | false |
