| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Kite Runner | - | - | - | $8,930,658 | 371 | $12,730,140 | Mar 28 | Filmauro | false |
| 2 | Step Up 2: The Streets | - | - | - | $4,929,343 | 333 | $5,313,261 | Apr 18 | Moviemax | false |
| 3 | Next | - | - | - | $4,424,652 | 289 | $4,522,275 | Apr 4 | Medusa Distribuzione | false |
| 4 | Tutta la vita davanti | - | - | - | $4,040,482 | 368 | $5,648,340 | Mar 28 | Medusa Distribuzione | false |
| 5 | Nim's Island | - | - | - | $3,783,810 | 304 | $4,095,643 | Apr 11 | Moviemax | false |
| 6 | Leatherheads | - | - | - | $3,165,973 | 218 | $3,763,108 | Apr 11 | Universal Pictures International (UPI) | false |
| 7 | 21 | - | - | - | $2,930,452 | 247 | $3,927,213 | Apr 18 | Sony Pictures Releasing | false |
| 8 | Horton Hears a Who! | - | - | - | $2,875,705 | 463 | $3,958,990 | Apr 18 | 20th Century Fox International | false |
| 9 | Juno | - | - | - | $2,728,885 | 239 | $3,352,339 | Apr 4 | 20th Century Fox International | false |
| 10 | La seconda volta non si scorda mai | - | - | - | $2,468,478 | 217 | $2,675,946 | Apr 11 | Mikado Film | false |
| 11 | Meet the Spartans | - | - | - | $2,378,740 | 286 | $3,769,624 | Apr 24 | 20th Century Fox International | false |
| 12 | Amore, bugie & calcetto | - | - | - | $2,174,497 | 313 | $2,222,029 | Apr 4 | Warner Bros. | false |
| 13 | Non pensarci | - | - | - | $1,750,953 | 222 | $2,239,655 | Apr 4 | 01 Distribution | false |
| 14 | The Eye | - | - | - | $937,315 | 177 | $937,315 | Apr 4 | Mediafilm | false |
| 15 | The Other Boleyn Girl | - | - | - | $887,857 | 102 | $2,180,712 | Apr 24 | Universal Pictures International (UPI) | false |
| 16 | The Oxford Murders | - | - | - | $794,144 | 100 | $817,983 | Apr 11 | Warner Bros. | false |
| 17 | The Last Deadly Mission | - | - | - | $775,168 | 161 | $829,466 | Apr 18 | Medusa Distribuzione | false |
| 18 | 27 Dresses | - | - | - | $749,339 | 263 | $3,860,905 | Mar 21 | 20th Century Fox International | false |
| 19 | Evening | - | - | - | $708,241 | 180 | $1,160,067 | Apr 24 | Medusa Distribuzione | false |
| 20 | Fool's Gold | - | - | - | $703,668 | 232 | $1,013,544 | Apr 23 | Warner Bros. | false |
| 21 | Questa notte è ancora nostra | - | - | - | $681,398 | 399 | $5,201,233 | Mar 20 | Walt Disney Pictures | false |
| 22 | The Demons of St. Petersburg | - | - | - | $663,980 | 110 | $1,409,678 | Apr 24 | 01 Distribution | false |
| 23 | Ci sta un francese, un inglese e un napoletano | - | - | - | $645,650 | 64 | $843,004 | Mar 28 | Medusa Distribuzione | false |
| 24 | The Spiderwick Chronicles | - | - | - | $612,303 | 262 | $3,505,964 | Mar 21 | Universal Pictures International (UPI) | false |
| 25 | The Fox and the Child | - | - | - | $569,906 | 240 | $2,400,103 | Mar 21 | Lucky Red | false |
| 26 | Shoot 'Em Up | - | - | - | $548,710 | 194 | $557,457 | Apr 11 | Eagle Pictures | false |
| 27 | 10,000 BC | - | - | - | $532,194 | 454 | $8,188,578 | Mar 14 | Warner Bros. | false |
| 28 | Before the Devil Knows You're Dead | - | - | - | $528,087 | 277 | $4,648,889 | Mar 14 | Medusa Distribuzione | false |
| 29 | Grande, grosso e... Verdone | - | - | - | $526,370 | 703 | $21,860,130 | Mar 7 | Filmauro | false |
| 30 | Colpo d'occhio | - | - | - | $453,023 | 387 | $4,057,969 | Mar 20 | 01 Distribution | false |
| 31 | Love Is Not Enough | - | - | - | $422,026 | 76 | $698,276 | Apr 18 | Mediafilm | false |
| 32 | Shine a Light | - | - | - | $405,436 | 57 | $479,849 | Apr 11 | BIM Distribuzione | false |
| 33 | My Blueberry Nights | - | - | - | $386,984 | 133 | $669,987 | Mar 28 | BIM Distribuzione | false |
| 34 | Over Her Dead Body | - | - | - | $369,433 | 133 | $507,321 | Apr 24 | Eagle Pictures | false |
| 35 | The Band's Visit | - | - | - | $333,031 | 51 | $919,800 | Mar 21 | Mikado Film | false |
| 36 | Introducing the Dwights | - | - | - | $309,169 | 69 | $386,825 | Apr 18 | Lucky Red | false |
| 37 | The Girl by the Lake | - | - | - | $261,056 | 143 | $4,688,666 | Sep 14 | Medusa Distribuzione | false |
| 38 | Good Morning Heartache | - | - | - | $251,842 | 79 | $278,471 | Apr 11 | Medusa Distribuzione | false |
| 39 | The Zone | - | - | - | $234,594 | 27 | $312,516 | Apr 4 | Sacher Distribuzione | false |
| 40 | 10 Items or Less | - | - | - | $200,040 | 35 | $226,695 | Apr 18 | DNC Entertainment | false |
| 41 | The Water Horse | - | - | - | $195,928 | 176 | $1,946,763 | Mar 14 | Sony Pictures Releasing | false |
| 42 | L'anno mille | - | - | - | $179,332 | 38 | $777,830 | Apr 24 | Mediafilm | false |
| 43 | La rabbia | - | - | - | $127,023 | 15 | $383,975 | Feb 29 | L'Altrofilm | false |
| 44 | Persepolis | - | - | - | $120,221 | 94 | $1,785,411 | Feb 22 | BIM Distribuzione | false |
| 45 | Interview | - | - | - | $113,717 | 44 | $113,717 | Apr 11 | Fandango | false |
| 46 | Dan in Real Life | - | - | - | $108,022 | 125 | $311,839 | Mar 28 | Eagle Pictures | false |
| 47 | Gone Baby Gone | - | - | - | $97,399 | 16 | $115,103 | Apr 4 | Walt Disney Pictures | false |
| 48 | No Country for Old Men | - | - | - | $97,213 | 308 | $8,979,650 | Feb 22 | Universal Pictures International (UPI) | false |
| 49 | U2 3D | - | - | - | $96,617 | 31 | $182,003 | Apr 24 | Independent Films | false |
| 50 | The Early Bird Catches the Worm | - | - | - | $73,685 | 253 | $1,550,893 | Feb 29 | Medusa Distribuzione | false |
| 51 | La velocità della luce | - | - | - | $72,817 | 9 | $72,817 | Apr 18 | Mediaplex | false |
| 52 | Cover Boy... Last Revolution | - | - | - | $71,368 | 8 | $147,184 | Mar 21 | Istituto Luce | false |
| 53 | Odette Toulemonde | - | - | - | $48,188 | 26 | $415,310 | Mar 7 | Warner Bros. | false |
| 54 | Jimmy della collina | - | - | - | $47,373 | 5 | $71,846 | Apr 4 | Aranciafilm | false |
| 55 | We Own the Night | - | - | - | $46,007 | 202 | $1,230,182 | Mar 14 | BIM Distribuzione | false |
| 56 | The Wind Blows Round | - | - | - | $45,306 | 15 | $659,151 | May 4 | Aranciafilm | false |
| 57 | Fallen Heroes | - | - | - | $44,484 | 22 | $81,917 | Mar 28 | BIM Distribuzione | false |
| 58 | There Will Be Blood | - | - | - | $38,615 | 111 | $2,566,966 | Feb 15 | Walt Disney Pictures | false |
| 59 | Biùtiful cauntri | - | - | - | $29,524 | 19 | $125,770 | Mar 7 | Lumière | false |
| 60 | Mr. Magorium's Wonder Emporium | - | - | - | $28,616 | 160 | $2,466,591 | Jan 25 | Moviemax | false |
| 61 | Happily N'Ever After | - | - | - | $24,525 | 172 | $1,366,579 | Mar 7 | DNC Entertainment | false |
| 62 | Andres and me | - | - | - | $18,362 | 1 | $49,196 | Apr 11 | - | false |
| 63 | Sonetàula | - | - | - | $17,828 | 16 | $283,454 | Mar 7 | Lucky Red | false |
| 64 | I Viceré | - | - | - | $16,952 | 187 | $2,584,556 | Nov 9 | 01 Distribution | false |
| 65 | L'aria del lago | - | - | - | $9,392 | 2 | $10,161 | Apr 11 | Independent Films | false |
| 66 | We Want Roses Too | - | - | - | $9,064 | 21 | $184,764 | Mar 7 | Mikado Film | false |
| 67 | La seconda volta | - | - | - | $8,540 | 1 | $1,151,013 | Oct 27 | Lucky Red | false |
| 68 | Eye of the Beholder | - | - | - | $7,657 | 1 | $201,355 | Nov 26 | Medusa Distribuzione | false |
| 69 | The Secret of the Grain | - | - | - | $6,192 | 79 | $2,875,013 | Jan 11 | Lucky Red | false |
| 70 | The Counterfeiters | - | - | - | $5,558 | 21 | $349,800 | Jan 25 | Lady Film | false |
| 71 | Sex and Death 101 | - | - | - | $4,539 | 91 | $536,405 | Mar 14 | Moviemax | false |
| 72 | Mars 2008 Re-release | - | - | - | $2,882 | 2 | $7,223 | Mar 28 | Officine UBU | false |
| 73 | Nelle tue mani | - | - | - | $2,185 | 18 | $111,266 | Mar 14 | Teodora Film | false |
| 74 | Days and Clouds | - | - | - | $2,100 | 214 | $6,010,383 | Oct 26 | Warner Bros. | false |
| 75 | Enchanted | - | - | - | $1,857 | 404 | $10,816,852 | Dec 7 | Walt Disney Pictures | false |
| 76 | Walk Hard: The Dewey Cox Story | - | - | - | $1,777 | 10 | $4,573 | Mar 28 | Sony Pictures Releasing | false |
| 77 | Away from Her | - | - | - | $1,677 | 31 | $136,316 | Feb 15 | Warner Bros. | false |
| 78 | American Gangster | - | - | - | $1,566 | 457 | $15,520,131 | Jan 18 | Universal Pictures International (UPI) | false |
