| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | 300 | - | - | - | $1,153,741 | 76 | $1,500,771 | Mar 29 | Warner Bros. | false |
| 2 | Meet the Robinsons | - | - | - | $262,004 | 39 | $519,115 | Apr 5 | Buena Vista International | false |
| 3 | The Reaping | - | - | - | $200,892 | 31 | $469,168 | Apr 5 | Warner Bros. | false |
| 4 | Ghost Rider | - | - | - | $186,517 | 36 | $268,740 | Apr 5 | Sony Pictures Releasing | false |
| 5 | Mr. Bean's Holiday | - | - | - | $138,765 | 25 | $309,265 | Apr 5 | United International Pictures | false |
| 6 | TMNT | - | - | - | $137,818 | 26 | $234,670 | Apr 5 | Bazuca Films | false |
| 7 | Ice Age 2: The Meltdown | - | - | - | $99,119 | 1 | $3,679,439 | Mar 30 | - | false |
| 8 | Apocalypto | - | - | - | $74,715 | 23 | $365,537 | Mar 8 | 20th Century Fox International | false |
| 9 | Arthur and the Invisibles | - | - | - | $73,620 | 25 | $167,575 | Mar 15 | Bazuca Films | false |
| 10 | Music and Lyrics | - | - | - | $67,517 | 27 | $209,768 | Mar 15 | Warner Bros. | false |
| 11 | The Holiday | - | - | - | $59,107 | 32 | $315,902 | Feb 22 | United International Pictures | false |
| 12 | Curse of the Golden Flower | - | - | - | $54,040 | 13 | $117,232 | Mar 22 | Sony Pictures Releasing | false |
| 13 | Night at the Museum | - | - | - | $49,218 | 74 | $1,893,724 | Jan 18 | 20th Century Fox International | false |
| 14 | Captain Alatriste: The Spanish Musketeer | - | - | - | $48,863 | 10 | $58,876 | Mar 29 | 20th Century Fox International | false |
| 15 | Shooter | - | - | - | $46,232 | 22 | $106,196 | Apr 12 | United International Pictures | false |
| 16 | Pathfinder | - | - | - | $45,255 | 18 | $122,882 | Apr 12 | 20th Century Fox International | false |
| 17 | Borat | - | - | - | $41,996 | 8 | $118,917 | Mar 15 | 20th Century Fox International | false |
| 18 | Pan's Labyrinth | - | - | - | $34,076 | 10 | $245,640 | Feb 22 | Warner Bros. | false |
| 19 | The Grudge 2 | - | - | - | $24,507 | 14 | $39,375 | Apr 12 | Transeuropa | false |
| 20 | Breaking and Entering | - | - | - | $21,249 | 2 | $28,138 | Mar 29 | Buena Vista International | false |
| 21 | The Pursuit of Happyness | - | - | - | $18,554 | 11 | $237,232 | Feb 8 | Sony Pictures Releasing | false |
| 22 | Notes on a Scandal | - | - | - | $17,047 | 5 | $106,392 | Mar 1 | 20th Century Fox International | false |
| 23 | Blood Diamond | - | - | - | $14,570 | 27 | $468,278 | Feb 1 | Warner Bros. | false |
| 24 | Happy Feet | - | - | - | $14,356 | 38 | $843,659 | Dec 1 | Warner Bros. | false |
| 25 | Deja Vu | - | - | - | $11,243 | 23 | $332,784 | Jan 11 | Buena Vista International | false |
| 26 | The Illusionist | - | - | - | $10,851 | 24 | $511,712 | Jan 11 | Transeuropa | false |
| 27 | The Last King of Scotland | - | - | - | $8,052 | 5 | $106,993 | Feb 15 | 20th Century Fox International | false |
| 28 | Letters from Iwo Jima | - | - | - | $7,685 | 10 | $147,616 | Feb 15 | Warner Bros. | false |
| 29 | Norbit | - | - | - | $7,206 | 22 | $124,903 | Mar 8 | United International Pictures | false |
| 30 | Garfield: A Tail of Two Kitties | - | - | - | $5,456 | 1 | $766,641 | Jul 20 | 20th Century Fox International | false |
| 31 | A Movie of Eggs | - | - | - | $1,509 | 15 | $62,762 | Jan 11 | Warner Bros. | false |
