| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Ice Age 2: The Meltdown | - | - | - | $15,313,270 | 544 | $25,985,050 | Apr 21 | 20th Century Fox International | false |
| 2 | Inside Man | - | - | - | $7,585,366 | 301 | $9,116,281 | Apr 7 | United International Pictures | false |
| 3 | Scary Movie 4 | - | - | - | $7,574,052 | 408 | $9,487,282 | Apr 21 | Buena Vista International | false |
| 4 | Il mio miglior nemico | - | - | - | $5,124,598 | 561 | $23,500,977 | Mar 10 | Filmauro | false |
| 5 | The Caiman | - | - | - | $4,518,970 | 386 | $8,571,161 | Mar 24 | Sacher Distribuzione | false |
| 6 | Basic Instinct 2 | - | - | - | $3,178,196 | 384 | $3,178,196 | Mar 31 | Warner Bros. | false |
| 7 | The Wild | - | - | - | $3,096,795 | 388 | $3,355,615 | Apr 13 | Buena Vista International | false |
| 8 | Notte prima degli esami | - | - | - | $2,486,387 | 327 | $15,905,030 | Feb 17 | 01 Distribution | false |
| 9 | Failure to Launch | - | - | - | $2,190,060 | 224 | $2,270,837 | Mar 31 | United International Pictures | false |
| 10 | Take the Lead | - | - | - | $1,969,623 | 351 | $5,672,559 | Apr 28 | Eagle Pictures | false |
| 11 | Just Like Heaven | - | - | - | $1,834,710 | 194 | $1,931,823 | Apr 14 | United International Pictures | false |
| 12 | Tristan + Isolde | - | - | - | $1,799,585 | 294 | $2,046,786 | Apr 7 | 20th Century Fox International | false |
| 13 | The Wedding Director | - | - | - | $1,586,617 | 209 | $2,468,448 | Apr 21 | 01 Distribution | false |
| 14 | Keeping Mum | - | - | - | $1,381,018 | 233 | $1,417,762 | Apr 14 | 01 Distribution | false |
| 15 | The Pink Panther | - | - | - | $1,359,395 | 346 | $3,258,916 | Mar 24 | 20th Century Fox International | false |
| 16 | Nanny McPhee | - | - | - | $1,301,035 | 223 | $1,436,735 | Apr 7 | Eagle Pictures | false |
| 17 | Eight Below | - | - | - | $1,106,505 | 159 | $1,130,829 | Mar 31 | Buena Vista International | false |
| 18 | Final Destination 3 | - | - | - | $1,051,973 | 272 | $2,767,155 | Mar 24 | Eagle Pictures | false |
| 19 | The Fog | - | - | - | $969,171 | 133 | $969,171 | Apr 14 | Sony Pictures Releasing | false |
| 20 | 16 Blocks | - | - | - | $827,753 | 170 | $827,753 | Mar 31 | 01 Distribution | false |
| 21 | Ti lascio perché ti amo troppo | - | - | - | $821,895 | 47 | $930,096 | Apr 14 | Mikado Film | false |
| 22 | ...e se domani | - | - | - | $690,421 | 97 | $704,645 | Apr 14 | Medusa Distribuzione | false |
| 23 | Firewall | - | - | - | $682,148 | 168 | $1,438,493 | Apr 28 | Warner Bros. | false |
| 24 | Into Great Silence | - | - | - | $655,909 | 47 | $897,895 | Mar 31 | Metacinema | false |
| 25 | Two for the Money | - | - | - | $510,767 | 150 | $1,123,368 | Apr 28 | United International Pictures | false |
| 26 | Where the Truth Lies | - | - | - | $459,374 | 71 | $459,374 | Apr 14 | Fandango | false |
| 27 | Ask the Dust | - | - | - | $372,253 | 140 | $844,879 | Apr 28 | Moviemax | false |
| 28 | V for Vendetta | - | - | - | $361,850 | 295 | $2,666,921 | Mar 17 | Warner Bros. | false |
| 29 | Atomised | - | - | - | $296,723 | 44 | $514,310 | Apr 21 | Lucky Red | false |
| 30 | Factotum | - | - | - | $271,092 | 60 | $271,092 | Mar 31 | Mikado Film | false |
| 31 | Zathura: A Space Adventure | - | - | - | $250,076 | 102 | $250,076 | Apr 7 | Sony Pictures Releasing | false |
| 32 | Our Land | - | - | - | $141,760 | 178 | $2,502,553 | Feb 24 | Medusa Distribuzione | false |
| 33 | In ascolto | - | - | - | $110,998 | 143 | $362,742 | Apr 28 | Medusa Distribuzione | false |
| 34 | Running Scared | - | - | - | $95,194 | 84 | $95,194 | Apr 14 | Warner Bros. | false |
| 35 | Terkel in Trouble | - | - | - | $66,065 | 68 | $66,065 | Apr 7 | Moviemax | false |
| 36 | Fire at My Heart | - | - | - | $60,800 | 53 | $60,800 | Mar 31 | Istituto Luce | false |
| 37 | Crash | - | - | - | $51,104 | 140 | $3,535,519 | Nov 11 | Filmauro | false |
| 38 | The Producers | - | - | - | $44,436 | 84 | $435,912 | Mar 17 | Sony Pictures Releasing | false |
| 39 | Sono tornato al nord | - | - | - | $44,082 | 38 | $44,082 | Apr 7 | Cineville Distribution | false |
| 40 | Syriana | - | - | - | $42,747 | 250 | $4,340,039 | Feb 24 | Warner Bros. | false |
| 41 | Wallace & Gromit: The Curse of the Were-Rabbit | - | - | - | $41,109 | 312 | $3,866,286 | Mar 3 | United International Pictures | false |
| 42 | To Paint or Make Love | - | - | - | $39,589 | 21 | $39,589 | Apr 7 | Lady Film | false |
| 43 | Lemming | - | - | - | $21,815 | 17 | $21,815 | Mar 31 | Lucky Red | false |
| 44 | The Constant Gardener | - | - | - | $21,370 | 190 | $1,054,754 | Mar 3 | BIM Distribuzione | false |
