| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Max Th | Opening | % of Total
| Open Th | Open | Close | Distributor
| Estimated
|
|---|
| 1 | When a Man Loves a Woman | - | - | - | $50,021,959 | 1,511 | - | - | - | Apr 29 | - | Walt Disney Studios Motion Pictures | false |
| 2 | Major League II | - | - | - | $30,626,182 | 2,167 | $7,040,777 | 23% | 2,167 | Apr 1 | - | Warner Bros. | false |
| 3 | With Honors | - | - | - | $20,016,254 | 1,222 | $4,328,543 | 21.6% | 1,102 | Apr 29 | - | Warner Bros. | false |
| 4 | No Escape | - | - | - | $15,339,030 | 1,765 | $4,588,736 | 29.9% | 1,763 | Apr 29 | - | Savoy Pictures | false |
| 5 | Bad Girls | - | - | - | $15,240,435 | 2,012 | $5,012,200 | 32.9% | 2,008 | Apr 22 | - | Twentieth Century Fox | false |
| 6 | Threesome | - | - | - | $14,815,317 | 1,218 | $4,001,024 | 27% | 1,212 | Apr 8 | - | TriStar Pictures | false |
| 7 | Cops and Robbersons | - | - | - | $11,391,093 | 1,836 | $3,724,254 | 32.7% | 1,831 | Apr 15 | - | TriStar Pictures | false |
| 8 | Thumbelina | - | - | - | $11,373,501 | 1,502 | $2,318,822 | 20.4% | 1,502 | Apr 1 | - | Warner Bros. | false |
| 9 | Martin Lawrence: You So Crazy | - | - | - | $10,184,701 | 517 | $2,521,746 | 24.8% | 417 | Apr 29 | - | The Samuel Goldwyn Company | false |
| 10 | The Inkwell | - | - | - | $8,880,705 | 513 | $2,358,988 | 26.6% | 390 | Apr 22 | - | Walt Disney Studios Motion Pictures | false |
| 11 | White Fang 2: Myth of the White Wolf | - | - | - | $8,878,839 | 1,877 | $2,692,624 | 30.3% | 1,853 | Apr 15 | - | Walt Disney Studios Motion Pictures | false |
| 12 | Serial Mom | - | - | - | $7,820,688 | 560 | $2,040,450 | 26.1% | 502 | Apr 13 | Aug 4 | Savoy Pictures | false |
| 13 | Surviving the Game | - | - | - | $7,727,256 | 1,034 | $2,907,468 | 37.6% | 1,025 | Apr 15 | - | New Line Cinema | false |
| 14 | Clifford | - | - | - | $7,408,745 | 1,023 | $2,571,043 | 34.7% | 1,014 | Apr 1 | - | Orion Pictures | false |
| 15 | The House of the Spirits | - | - | - | $6,265,311 | 476 | $1,719,085 | 27.4% | 474 | Apr 1 | - | Miramax | false |
| 16 | Brainscan | - | - | - | $4,352,094 | 1,221 | $1,725,000 | 39.6% | 1,221 | Apr 22 | - | Triumph Releasing Corporation | false |
| 17 | PCU | - | - | - | $4,330,020 | 1,741 | $2,129,483 | 49.2% | 1,741 | Apr 29 | - | Twentieth Century Fox | false |
| 18 | Jimmy Hollywood | - | - | - | $3,783,003 | 944 | $1,451,000 | 38.4% | 944 | Apr 1 | - | Paramount Pictures | false |
| 19 | The Favor | - | - | - | $3,134,381 | 1,029 | $1,487,238 | 47.4% | 1,029 | Apr 29 | - | Orion Pictures | false |
| 20 | Backbeat | - | - | - | $2,392,589 | 211 | $126,740 | 5.3% | 10 | Apr 15 | Jun 16 | Gramercy Pictures (I) | false |
| 21 | Leprechaun 2 | - | - | - | $2,260,622 | 252 | $672,775 | 29.8% | 252 | Apr 8 | - | Trimark Pictures | false |
| 22 | Chasers | - | - | - | $1,596,687 | 782 | $733,859 | 46% | 782 | Apr 22 | - | Warner Bros. | false |
| 23 | Naked in New York | - | - | - | $1,038,959 | - | - | - | - | Apr 13 | - | Fine Line Features | false |
| 24 | Holy Matrimony | - | - | - | $713,234 | - | - | - | - | Apr 8 | - | Walt Disney Studios Motion Pictures | false |
| 25 | Cronos | - | - | - | $621,392 | 28 | $17,538 | 2.8% | 2 | Apr 1 | - | October Films | false |
| 26 | In Custody | - | - | - | $92,612 | 3 | $7,701 | 8.3% | 3 | Apr 15 | - | Sony Pictures Classics | false |
| 27 | High Lonesome: The Story of Bluegrass Music | - | - | - | $53,319 | 2 | $9,571 | 18% | 1 | Apr 29 | Jul 7 | Tara Releasing | false |
| 28 | L.627 | - | - | - | $28,540 | - | - | - | - | Apr 8 | - | Kino International | false |
| 29 | The Secret Rapture | - | - | - | $18,719 | - | - | - | - | Apr 29 | May 26 | Castle Hill Productions | false |
