| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Four Christmases | - | - | - | $46,054,468 | 3,540 | $120,146,040 | Nov 26 | Warner Bros. | false |
| 2 | Twilight | - | - | - | $39,540,889 | 3,649 | $192,769,854 | Nov 21 | Summit Entertainment | false |
| 3 | Bolt | - | - | - | $35,995,522 | 3,654 | $114,053,579 | Nov 21 | Walt Disney Studios Motion Pictures | false |
| 4 | Quantum of Solace | - | - | - | $27,487,933 | 3,501 | $168,368,427 | Nov 14 | Sony Pictures Releasing | false |
| 5 | Australia | - | - | - | $20,004,456 | 2,721 | $49,554,002 | Nov 26 | Twentieth Century Fox | false |
| 6 | Madagascar: Escape 2 Africa | - | - | - | $19,154,953 | 4,065 | $180,010,950 | Nov 7 | DreamWorks | false |
| 7 | Transporter 3 | - | - | - | $18,230,758 | 2,626 | $31,715,062 | Nov 26 | Lionsgate | false |
| 8 | Role Models | - | - | - | $7,693,480 | 2,798 | $67,294,270 | Nov 7 | Universal Pictures | false |
| 9 | The Boy in the Striped Pajamas | - | - | - | $2,199,240 | 679 | $9,046,156 | Nov 7 | Miramax | false |
| 10 | Milk | - | - | - | $1,941,472 | 882 | $31,841,299 | Nov 26 | Focus Features | false |
| 11 | Slumdog Millionaire | - | - | - | $1,767,019 | 2,943 | $141,319,928 | Nov 12 | Fox Searchlight Pictures | false |
| 12 | Changeling | - | - | - | $1,601,140 | 1,896 | $35,739,802 | Oct 24 | Universal Pictures | false |
| 13 | High School Musical 3: Senior Year | - | - | - | $1,445,033 | 3,626 | $90,559,416 | Oct 24 | Walt Disney Studios Motion Pictures | false |
| 14 | Zack and Miri Make a Porno | - | - | - | $751,015 | 2,735 | $31,457,946 | Oct 31 | The Weinstein Company | false |
| 15 | The Secret Life of Bees | - | - | - | $726,486 | 1,630 | $37,770,162 | Oct 17 | Fox Searchlight Pictures | false |
| 16 | Soul Men | - | - | - | $598,976 | 2,048 | $12,082,391 | Nov 7 | Metro-Goldwyn-Mayer (MGM) | false |
| 17 | Fireproof | - | - | - | $585,524 | 905 | $33,456,317 | Sep 26 | The Samuel Goldwyn Company | false |
| 18 | The Dark Knight | - | - | - | $475,640 | 4,366 | $533,345,358 | Jul 18 | Warner Bros. | false |
| 19 | Happy-Go-Lucky | - | - | - | $365,115 | 202 | $3,512,016 | Oct 10 | Miramax | false |
| 20 | Eagle Eye | - | - | - | $339,984 | 3,614 | $101,440,743 | Sep 26 | DreamWorks | false |
| 21 | The Polar Express 2008 IMAX Release | - | - | - | $184,845 | 26 | $1,705,694 | Nov 21 | Warner Bros. | false |
| 22 | Saw V | - | - | - | $161,232 | 3,084 | $56,746,769 | Oct 24 | Lionsgate | false |
| 23 | Righteous Kill | - | - | - | $150,981 | 3,152 | $40,081,410 | Sep 12 | Overture Films | false |
| 24 | Igor | - | - | - | $137,704 | 2,341 | $19,528,602 | Sep 19 | Metro-Goldwyn-Mayer (MGM) | false |
| 25 | Body of Lies | - | - | - | $114,440 | 2,714 | $39,394,666 | Oct 10 | Warner Bros. | false |
| 26 | Burn After Reading | - | - | - | $112,633 | 2,657 | $60,355,347 | Sep 12 | Focus Features | false |
| 27 | Max Payne | - | - | - | $108,118 | 3,381 | $40,689,393 | Oct 17 | Twentieth Century Fox | false |
| 28 | Appaloosa | - | - | - | $92,927 | 1,290 | $20,211,394 | Sep 19 | Warner Bros. | false |
| 29 | The Haunting of Molly Hartley | - | - | - | $92,412 | 2,652 | $13,559,812 | Oct 31 | Freestyle Releasing | false |
| 30 | Religulous | - | - | - | $84,378 | 568 | $13,011,160 | Oct 1 | Lionsgate | false |
| 31 | W. | - | - | - | $73,894 | 2,050 | $25,534,493 | Oct 17 | Lionsgate | false |
| 32 | City of Ember | - | - | - | $71,043 | 2,023 | $7,873,007 | Oct 10 | Twentieth Century Fox | false |
| 33 | Deep Sea | - | - | - | $66,284 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 34 | The Duchess | - | - | - | $61,228 | 1,207 | $13,848,978 | Sep 19 | Paramount Vantage | false |
| 35 | Vicky Cristina Barcelona | - | - | - | $53,436 | 726 | $23,216,709 | Aug 15 | Metro-Goldwyn-Mayer (MGM) | false |
| 36 | RocknRolla | - | - | - | $50,589 | 826 | $5,700,626 | Oct 8 | Warner Bros. | false |
| 37 | Nights in Rodanthe | - | - | - | $43,012 | 2,704 | $41,850,659 | Sep 26 | Warner Bros. | false |
| 38 | Journey to the Center of the Earth | - | - | - | $27,996 | 2,830 | $101,704,370 | Jul 11 | Warner Bros. | false |
| 39 | Noah's Arc: Jumping the Broom | - | - | - | $24,883 | 9 | $532,878 | Oct 24 | Logo | false |
| 40 | Pride and Glory | - | - | - | $18,199 | 2,585 | $15,740,721 | Oct 24 | Warner Bros. | false |
| 41 | Sex Drive | - | - | - | $17,755 | 2,421 | $8,402,485 | Oct 17 | Summit Entertainment | false |
| 42 | Repo! The Genetic Opera | - | - | - | $13,863 | 11 | $146,750 | Nov 7 | Lionsgate | false |
| 43 | My Name Is Bruce | - | - | - | $13,284 | 4 | $173,066 | Oct 31 | Image Entertainment | false |
| 44 | Were the World Mine | - | - | - | $11,214 | 4 | $123,789 | Oct 31 | SPEAK Productions | false |
| 45 | How to Lose Friends & Alienate People | - | - | - | $7,313 | 1,750 | $2,778,752 | Oct 3 | Metro-Goldwyn-Mayer (MGM) | false |
| 46 | Hounddog | - | - | - | $3,825 | 11 | $131,961 | Sep 19 | Empire Pictures Inc. | false |
| 47 | I.O.U.S.A. | - | - | - | $3,406 | 358 | $821,046 | Aug 22 | Roadside Attractions | false |
| 48 | The First Basket | - | - | - | $1,759 | 4 | $20,440 | Oct 29 | Laemmle/Zeller Films | false |
| 49 | The Alphabet Killer | - | - | - | $1,714 | 2 | $29,784 | Nov 7 | Anchor Bay Films | false |
| 50 | House | - | - | - | $1,024 | 363 | $575,048 | Nov 7 | Roadside Attractions | false |
| 51 | Lola Montès | - | - | - | $798 | 4 | $120,306 | Oct 10 | Rialto Pictures | false |
| 52 | The Other End of the Line | - | - | - | $782 | 91 | $115,592 | Oct 31 | Metro-Goldwyn-Mayer (MGM) | false |
| 53 | Eden | - | - | - | $435 | 3 | $15,611 | Nov 14 | Liberation Entertainment | false |
